The primary cilium at the helm: gatekeeper of TGF-β superfamily signaling in development, homeostasis, and disease [0.03%]
掌舵的主纤毛：发育、稳态和疾病中TGF-β超家族信号传导的把门人
Cristian Herrera-Cid,Oskar Kaaber Thomsen,Linéa Désarbre et al.
Cristian Herrera-Cid et al.
The transforming growth factor-beta (TGF-β) superfamily is crucial for regulating cell proliferation, differentiation, migration, and tissue homeostasis, and plays a central role in embryonic development and function of tissues and organs....
Insight into the relationship between type IV pilus function and biofilm formation [0.03%]
IV型菌毛功能与黏附形成的关系探讨
Yafan Yu,Robert M Bauer,Rabab Mahdi et al.
Yafan Yu et al.
Type IV pili (T4P) are protein nanofibers that can be extended and retracted from the surfaces of many bacterial taxa. They are involved in many aspects of bacterial physiology that differ between bacterial species, including surface motili...
A pore is a pore is a pore (or a hub?): VDAC oligomerization in mitochondrial connectivity and modulation [0.03%]
一个孔是一个孔是一个孔（还是一个枢纽？）：线粒体连接性和调节中的VDAC寡聚化
Vito De Pinto,Giuseppe Battiato,Stefano Conti-Nibali et al.
Vito De Pinto et al.
For decades, the voltage-dependent anion-selective channel (VDAC), formerly known as the mitochondrial porin, was considered a simple pore enabling nearly free permeability across the outer mitochondrial membrane. This simplified view has b...
Chanakarn Mongkonpruthangkoon,Nitai C Giri,Partha Basu
Chanakarn Mongkonpruthangkoon
Nitrate reductases are molybdenum cofactor (Moco)-containing enzymes that reduce nitrate to nitrite, the first step in assimilatory and dissimilatory nitrate reduction to ammonia, and in denitrification. Nitrate reductases are divided into ...
Dissecting conserved molecular mechanisms of biological toxin activity through CRISPR screening [0.03%]
通过CRISPR筛选分析生物毒性的保守分子机制
Matthew A Waller,Tian Y D&#x;Araujo,Christopher E Denes et al.
Matthew A Waller et al.
Toxins, substances that are produced by living organisms with the potential to cause harm, demonstrate great diversity in their structure, function, and origin. Though some toxins have been repurposed for use as novel therapeutics, research...
RNA-binding protein hnRNPK: a multifunctional regulator of skeletal muscle biology and disease [0.03%]
RNA结合蛋白hnRNPK：骨骼肌生物学和疾病的重要调节因子
Kejin Ren,Kaili Zhou,Yijia An et al.
Kejin Ren et al.
Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is a highly conserved, multifunctional DNA/RNA-binding protein that regulates gene expression at both transcriptional and post-transcriptional levels. In skeletal muscle, hnRNPK is essentia...
G0 or no-G0: phosphatase control of quiescence and cell cycle entry [0.03%]
有G0期和无G0期：磷酸酶对静止状态和细胞周期进入的调控
Eleanor A Robinson,Alexis R Barr
Eleanor A Robinson
During each cell cycle, cells must decide whether to continue to proliferate or to exit the cell cycle into a reversible arrest state, known as quiescence, or G0. This decision must be highly regulated to ensure proper tissue homeostasis. S...
Direct or indirect: the crucial role of N-palmitate in hedgehog signaling [0.03%]
直接或间接：N-棕榈酸在 Hedgehog 信号传导中的关键作用
Janna Puschmann,Kay Grobe
Janna Puschmann
During development, cells use concentration gradients of soluble signaling molecules, called morphogens, to determine their position within tissues and adopt the correct identity. Hedgehog (Hh) morphogens are a key but also unusual example ...
Pro-inflammatory cytokine-driven molecular signaling in skeletal muscle during cancer cachexia [0.03%]
癌症恶病质期间肌肉组织中促炎症细胞因子驱动的分子信号转导路径研究
Benudhara Pati,Nibedita Nandy,Birendra Kumar Bindhani et al.
Benudhara Pati et al.
Cancer cachexia is a multifactorial syndrome characterized by the progressive loss of muscle and fat, commonly observed among patients with cancer. It is very distinct from other skeletal muscle wasting such as sarcopenia and malnutrition a...
Min Cao,Glenn R Masson
Min Cao
Haem-regulated inhibitor (HRI) is emerging as a potential therapeutic target in several disease areas, including cancers such as multiple myeloma and neurodegenerative disease. As one of four related mammalian kinases that phosphorylate the...