Raquel A C Machado,Ivan Rosa E Silva,Thaís Fontes-Milz et al.
Raquel A C Machado et al.
The self-assembly of metabolic enzymes into filaments and other supramolecular structures is well-documented in bacteria and yeast but remains largely unexplored in mammalian cells. Enzyme filamentation is thought to play a crucial role in ...
Christine H Foyer
Christine H Foyer
Reactive oxygen species (ROS) are ubiquitous signalling molecules that serve to integrate developmental, metabolic and stress signals to shape adaptive outcomes, linking energy metabolism to plant physiology, growth and stress resilience in...
The integrated stress response in cancer: mechanisms of tumor adaptation and therapeutic targeting [0.03%]
整合应激反应在癌症中的作用：肿瘤适应机制及治疗靶向策略
Elias Maldonado,Emily McIsaac,Josie Ursini-Siegel
Elias Maldonado
Cancer cells face continual stressors, which they must overcome to proliferate and survive in the body. Under these conditions, essential biochemical pathways are disrupted, contributing to various stress responses that either promote adapt...
Headtlove Essel Dadzie,Eric L Snyder
Headtlove Essel Dadzie
Hepatocyte nuclear factor 4 alpha (HNF4α) is a conserved nuclear receptor that governs epithelial identity and metabolic homeostasis across endoderm-derived tissues. In cancer, HNF4α can function as either an oncogene or a tumor suppresso...
Advances in polarised luminescence approaches to understanding interactions between biomolecules [0.03%]
用于理解生物分子间相互作用的偏振发光方法研究进展
Edan Habel,Pinky Vishwakarma,Thomas Huber et al.
Edan Habel et al.
Luminescence spectroscopies are attractive due to their sensitivity and selectivity. Polarised light provides added dimensions to luminescence data, leading to techniques that provide information about molecular structure and interactions. ...
Sensing of double-stranded RNA in human cells: molecular mechanisms and cellular consequences [0.03%]
哺乳动物细胞中的双链RNA感应：分子机制和细胞效应
Julia Cieslicka,Karolina Pianka,Karolina Drazkowska et al.
Julia Cieslicka et al.
Double-stranded RNA (dsRNA) is a universal indicator of viral replication and dysregulated RNA metabolism. Detection of dsRNA triggers some of the most powerful innate immune responses in human cells. Although these molecules differ in orig...
Reprogramming the inactive X chromosome: dynamics and insights from the germline [0.03%]
重新激活失活的X染色体：从生殖细胞获得的动力学和见解
Yolanda Moyano Rodriguez,Maud Borensztein
Yolanda Moyano Rodriguez
Germline reprogramming is an essential process that resets the epigenome prior to gamete formation. Primordial germ cells (PGCs), the progenitors of oocytes and spermatozoa, undergo extensive epigenetic remodelling during development, inclu...
Breaking cellular boundaries: molecular mechanisms of tunneling nanotube formation and fusion [0.03%]
突破细胞界限：穿膜纳米管形成和融合的分子机制
Sevan Belian,Chiara Zurzolo
Sevan Belian
Tunneling nanotubes (TNTs) are thin, actin-based membrane bridges that establish direct cytoplasmic continuity between distant cells, enabling the transfer of diverse cargoes ranging from ions and proteins to organelles such as mitochondria...
Shachar Guy Bressler,Dana Grunhaus,Mattan Hurevich et al.
Shachar Guy Bressler et al.
Protein phosphorylation is one of the most common and versatile regulatory mechanisms in cells. Most human proteins are phosphorylated at multiple sites, giving rise to large numbers of possible phosphorylation patterns. Each phosphorylatio...
Sydney S Skirboll,Anastasia E Ledinina,Thomas M Makris
Sydney S Skirboll
The first heme oxygenase-like dimetal oxidase/oxygenase (HDO) was functionally validated through coordinated spectroscopic and rapid kinetic studies of the fatty acid decarboxylase UndA. The enzyme superfamily has since been recognized to o...