Navigating lipid droplet proteins - part I: ER targeting routes of lipid droplet-destined membrane proteins [0.03%]
脂滴蛋白的导航（I）：脂滴定域膜蛋白的内质网靶向路径
Louisa Magdalena Krauß,Bianca Schrul
Louisa Magdalena Krauß
Lipid droplets (LDs) are cytosolic lipid storage organelles that derive from the endoplasmic reticulum (ER). Their biogenesis and function are essential for maintaining cellular lipid homeostasis and require a spatiotemporally co-ordinated ...
Navigating lipid droplet proteins - part II: molecular mechanisms underlying ER-to-lipid droplet protein partitioning [0.03%]
脂滴蛋白的导航之二：内质网至脂滴蛋白质分配的分子机制
Louisa Magdalena Krauß,Bianca Schrul
Louisa Magdalena Krauß
Lipid droplets (LDs) originate from the endoplasmic reticulum (ER) and are unique among cellular organelles, as they consist of a hydrophobic core of neutral lipids that is surrounded by a phospholipid monolayer. Proteins and enzymes embedd...
Hina Sultana,Rohit Kunar,A Gregory Matera
Hina Sultana
The human genome attains an amazing spatial organization in the packaging of 2 m of DNA into a 10-μm nucleus. Such structural organization is achieved by the folding of chromatin and the regulation exerted by architectural proteins such as...
Encarnacion Martínez-Salas PhD
Encarnacion Martínez-Salas PhD
RNA and proteins are key components of all organisms. Internal ribosome entry site (IRES) elements are a diverse type of RNA regulatory structural elements that mediate end-independent, internal translation initiation in viral mRNAs and cer...
Are you having a LaPh? Diverse roles of Labile Phosphorylation in mammalian cells [0.03%]
动态磷酸化修饰在哺乳动物细胞中的多样性作用
Christopher J Clarke,Claire E Eyers
Christopher J Clarke
Phosphorylation plays a central role in regulating signal transduction across all kingdoms of life, allowing organisms to sense and respond to their environment. In mammals, the signalling research field is dominated by the functions of pSe...
Deubiquitylases and nucleases in bacterial symbiont-induced cytoplasmic incompatibility [0.03%]
细菌共生体诱导的胞质不相容性的脱泛素酶和核酸酶
Seun O Oladipupo,Mark Hochstrasser
Seun O Oladipupo
In myriad arthropod species, maternally transmitted symbiotic bacteria spread through populations by manipulating host reproduction, most frequently by a mechanism called cytoplasmic incompatibility (CI). CI occurs when bacterially infected...
Arno F Alpi,Jakub Chrustowicz,Dawafuti Sherpa et al.
Arno F Alpi et al.
The GID/C-terminal to LisH (CTLH) E3 is an emerging family of evolutionarily conserved multiprotein E3 ligase complexes implicated in various biological processes including metabolic rewiring, stress-responsive regulation, cellular differen...
Christopher J Calo,Margaret Radke,Tanvi Patil et al.
Christopher J Calo et al.
Neutrophils play a critical role in maintaining healthy tissue by acting as the first cellular responders to inflammatory challenges. Unfortunately, when this response is dysregulated, defects in neutrophil function can contribute to the pa...
FASTK post-transcriptional regulators - a 'FAST-tracK' in mitochondrial gene expression [0.03%]
快速转录后调节因子 FASTK--调控线粒体基因表达的新途径
Justin Van Riper,Bridget J Corsaro,Monica C Pillon
Justin Van Riper
Fas-activated serine/threonine kinase (FASTK) proteins comprise one of the largest families of mitochondrial post-transcriptional regulators. Members are classified based on their conserved C-terminus, which shows homology with the PD-(D/E)...
Transcriptional condensates and the nuclear pore complex regulate gene expression and 3D genome architecture in response to stress [0.03%]
转录凝聚体和核孔复合物通过响应压力来调节基因表达和三维基因组结构
Suman Mohajan,David S Gross
Suman Mohajan
Cells respond to thermal, chemical, and oxidative stress by activating an evolutionarily conserved adaptive mechanism known as the heat shock response (HSR) that maintains protein homeostasis and ensures cell survival. Central to the HSR is...