In Silico Characterization and Molecular Docking of the L-Arginase Gene From Alcaligenes aquatilis BC2 [0.03%]
来源于水生阿氏不动杆菌BC2的L-精氨酸酶基因的生物信息学特征及分子对接研究
Birhan Getie Assega,Kefyalew Ayalew Getahun,Tamene Milkessa Jiru et al.
Birhan Getie Assega et al.
L-arginine is a vital amino acid metabolized by L-arginase, an enzyme with growing biotechnological and therapeutic significance, particularly in cancer treatment. This study presents a comprehensive in silico characterization of the L-argi...
Therapeutic Potential of Ginger Rhizomes (Zingiber officinale) on Leukemia [0.03%]
姜黄属姜根茎（Zingiber officinale）对白血病的治疗潜力
Abdolhossein Hajizadeh,Parmida Nafei,Kimiya Seraj et al.
Abdolhossein Hajizadeh et al.
Leukemia continues to provide a significant therapeutic challenge due to relapse, medication resistance, and treatment-associated toxicity, which frequently hinder sustained disease management. Rhizomes of ginger (Zingiber officinale) posse...
N-3 PUFAs Enhancing Chemotherapy Efficacy in Acute Myeloid Leukemia While Safeguarding Healthy Cells [0.03%]
n-3 多不饱和脂肪酸增强急性髓系白血病化疗疗效并保护正常细胞
Pradnya Gurav,Aruna Sivaram,R N Kedar
Pradnya Gurav
Acute myeloid leukemia (AML) is a rapidly progressing blood cancer with poor survival rates, necessitating aggressive treatment strategies like chemotherapy. Doxorubicin (DOXO) is commonly used but is limited by severe side effects, includi...
Identification, Heterologous Expression, and Characterization of a New α-Galactosidase From Geobacillus kaustophilus [0.03%]
解链芽孢杆菌耐热α-半乳糖苷酶的鉴定、异源表达及性质研究
Aslı Kus,Yunus Ensari
Aslı Kus
α-Galactosidase enzymes have a variety of applications in numerous areas, including medicine, energy, food, feed, prebiotics, and paper pulp production. A single α-galactosidase gene was identified in the Geobacillus kaustophilus genome t...
Exploring Molecular Signature and Prognostic Biomarkers in Ovarian Cancer: Insights From Late-Stage, Recurrent, and Metastatic Tumors [0.03%]
探索卵巢癌分子特征及预后生物标志物：来自晚期、复发和转移性肿瘤的启示
Vandana Yadav,Aruna Sivaram,Renu Vyas
Vandana Yadav
Ovarian Cancer is a leading cause of mortality among women globally, primarily due to lack of specific and sensitive early-stage diagnostic tools. This study aims to identify hub genes associated with recurrent, late-stage, and metastatic t...
Cost-Effective and User-Friendly Pencil Graphite Electrode Immunosensor for Label-Free Detection of Carcinoembryonic Antigen [0.03%]
一种用于无标记检测癌胚抗原的低成本且用户友好的铅笔石墨电极免疫传感器
Sevda Akay Sazaklioglu,Hüseyin Çelikkan
Sevda Akay Sazaklioglu
We present a novel, cost-effective sensor for carcinoembryonic antigen (CEA) detection utilizing a pencil graphite electrode (PGE) in combination with electrochemical impedance spectroscopy (EIS), which offers high sensitivity and selectivi...
Pseudomonas aeruginosa Peptide From Strain P3 (PAP3) and AKT Serine/Threonine Kinase 1 (AKT1) siRNA-Loaded Chitosan Nanoparticle as a Co-Delivery System for Enhanced Anticancer Activity in Lung Cancer Cells [0.03%]
负载来自P3菌株的铜绿假单胞肽(PAP3)和Akt丝裂原活化蛋白激酶1(AKT1)siRNA的壳聚糖纳米颗粒复合递送系统在肺癌细胞中的抗肿瘤活性研究
Shabeer Padariyakam,Nimisha R Nair,Shanker Lal Kothari
Shabeer Padariyakam
Multidrug-resistant tumor cells pose significant challenges in cancer treatment. Alternative strategies such as targeted gene silencing and the use of compounds with minimal cytotoxicity toward normal cells are therefore of great interest. ...
A Novel Domain Adaptation Framework for Wearable Human Activity Recognition Using Multi-Sensor Feature Alignment [0.03%]
一种基于多传感器特征对齐的可穿戴人类活动识别领域适应框架
Prawar Chaudhary,Chintan Singh,Roobal Chaudhary et al.
Prawar Chaudhary et al.
Wearable Human Activity Recognition (HAR) models often degrade across users and sensor placements due to domain shifts. This paper presents the Multi-Sensor Adaptive Feature Alignment Network (MSAFAN), integrating Sensor-Specific Normalizat...
A Quartz Tuning Fork-Based Immunosensor for Detection of Kidney Injury Molecule-1: A New Working Electrode for Electrochemical Applications [0.03%]
一种石英叉基免疫传感器用于检测肾脏损伤分子-1：电化学生物传感的新工作电极
Şeyma Şentürk Özkan,Mustafa Kemal Sezgintürk
Şeyma Şentürk Özkan
Kidney injury molecule-1 (KIM-1) is a Type I transmembrane glycoprotein and is a potential biomarker for detecting kidney damage, as its urinary levels fluctuate in cases of acute kidney injury. In this study, an electrochemical immunosenso...
Protein Secondary Structure Prediction Using Soft Computing Techniques [0.03%]
基于软计算技术的蛋白质二级结构预测方法研究
Sajani K,Pragyendu Yaduvanshi,Sarfaraz Masood et al.
Sajani K et al.
Accurate prediction of protein secondary structure is a critical step toward understanding protein function and facilitating structure‑based drug discovery. We present a template‑independent, single sequence method utilizing a shallow fee...