High-Throughput Virtual Screening of Phytochemicals From Indian Medicinal Plants for the Identification of Potential Inhibitors Against NS2B-NS3 Protease of Dengue Virus [0.03%]
用于筛选印度草药植物中针对登革热病毒NS2B-NS3蛋白酶的潜在抑制剂的高通量虚拟筛选研究
Kandavelmani Angamuthu,Saranya Nallusamy,Poongodi Thangavel et al.
Kandavelmani Angamuthu et al.
Dengue is an acute mosquito-borne viral infection that has become a major health problem worldwide in recent years. Currently, no specific antiviral therapies are available to treat dengue fever. Every year, an enormous number of deaths are...
1-Alkyl-1H-Benzimidazolium Sulfonates as Non-Competitive Inhibitors of Polyphenol Oxidase [0.03%]
1-烷基-1H-苯并咪唑
Adem Ergün,Kübra Çikrikci,Nahit Gençer et al.
Adem Ergün et al.
Polyphenol oxidase (PPO) has been the subject of many inhibition studies due to its presence in many species, causing enzymatic browning in fruits and vegetables, and its pigmentation role in mammalian species. In the present study, the inh...
miR-16-5p Attenuated Airway Inflammation and Pulmonary Fibrosis of Asthma Rats by Regulating the TGF-β1/Smad3 Signaling [0.03%]
miR-16-5p通过调节TGF-β1/Smad3信号通路减轻哮喘大鼠气道炎症和肺纤维化
Weiwei She,Tianshou Sun,Chengfeng Long et al.
Weiwei She et al.
Bronchial asthma is a significant inflammatory disorder impacting the airways. While current therapeutic interventions manage these symptoms, they do not offer a cure for the condition. Emerging research indicates that specific microRNAs (m...
Polyethylene Carboxylates Synthesized via Statistical Optimization: A Biocompatible Polymer Scaffold for Bioactive Conjugation [0.03%]
基于统计优化的聚乙烯羧酸酯的合成：用于生物活性接枝的生物相容性聚合物骨架
Vinay Sagar Verma,Rajesh Choudhary,Amit Alexander et al.
Vinay Sagar Verma et al.
The study aimed to synthesize and evaluate polyethylene carboxylates (PECs) as a biocompatible polymer for drug delivery. The synthesis of PECs has been achieved by making slight modifications through statistical optimization in reaction co...
The Function of Secondary Metabolites and Associated Genes in Combatting Abiotic Stress Caused by Chromium Nitrate in Amaranthus viridis L [0.03%]
青葙子次生代谢产物及其相关基因抗硝酸铬等非生物胁迫的功能研究
Pratik Talukder,Titli Debnath,Titiksha Singh et al.
Pratik Talukder et al.
Green amaranth, or Amaranthus viridis L., is a plant that thrives in warmer climates worldwide. Additionally, the whole plant has analgesic and antipyretic properties, which serve to treat fever and pain, respectively, in traditional medici...
A Study of the Biomarker Responses of Water Spinach Grown in Polluted Water [0.03%]
污染条件下空心菜生物标志物响应研究
Susmita Mukherjee,Soham Roy,Ayan Chowdhury et al.
Susmita Mukherjee et al.
A pond ecosystem is one of the most important freshwater ecosystems. It serves as the home to various flora and fauna. Ipomoea aquatica, or water spinach, is a common pond water plant. It is consumed by people for its taste and health benef...
Exploring Plumbagin as a Potential Phytochemical to Combat Multidrug Resistance in Bacterial Strains [0.03%]
探究草海桐素作为对抗细菌菌株多药耐药潜在植物化学物质的可能性
Jyoti Deshpande,Amol Phule,Arpita Lenka et al.
Jyoti Deshpande et al.
The clinical efficacy of existing antibiotics is threatened by the emergence of multidrug-resistant pathogens. In India, traditional herbal medicine has attracted much of the scientific interest and increasing continuously. This study evalu...
Synthesis and in Silico Evaluation of Novel Triazolone-Derived Naphthalene-2-Sulfonates, Evaluation of Potential Antiproliferative Agents and Enzyme Inhibitory Activities [0.03%]
新型三唑酮衍生物萘-2-磺酸的合成及计算评估，潜在抗增殖剂和酶抑制剂活性的评价
Onur Akyıldırım,Abdülmelik Aras,Ercan Oguz et al.
Onur Akyıldırım et al.
This study reports the synthesis and biological evaluation of four novel N-acetyl-derived heterocyclic compounds, namely 2-((1-acetyl-3-substituted-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)iminomethyl)-phenyl-naphthalene-2-sulfonates. The co...
Influence of nonpolar aliphatic amino acids on Pseudomonas aeruginosa for virulence factors production [0.03%]
非极性脂肪族氨基酸对绿脓杆菌毒力因子产生的影响
Arya Ramesh,Abinaya Kanagaraja,Subash C B Gopinath et al.
Arya Ramesh et al.
Multidrug-resistant (MDR) microorganisms are widely recognized as a public health concern due to the antibiotic resistance, which is a major risk to global human health. Amino acids have been utilized to produce antimicrobial peptides as th...
Computer-Aided Identification and Molecular Interaction Analyses of Annona muricata Acetogenins Against LuxS [0.03%]
计算机辅助 annonamuricata 醇提取物黄烷醇化合物的鉴定及其与 luxs 的分子间相互作用分析
Titilayomi Adewusi,Victor Markus,Chidi W Nwekwo et al.
Titilayomi Adewusi et al.
Antibiotic resistance, which renders existing antibiotics ineffective against bacterial infections, is among the top-most pressing global public health challenges. A promising strategy to combat bacterial infection without inducing the occu...