Maternal dietary fibre intake results in sex-specific single-cell molecular changes in the heart of the offspring [0.03%]
母体饮食中的膳食纤维摄入会影响后代心脏的性别特异性单细胞分子变化
Chaoran Yang,Hamdi A Jama,Malathi S I Dona et al.
Chaoran Yang et al.
Some types of dietary fibre undergo fermentation by the gut microbiome, producing microbial metabolites called short-chain fatty acids (SCFAs) - these are protective against cardiovascular disease (CVD). Emerging evidence suggests that mate...
Evaluating short-chain fatty acids in breath condensate as surrogate measurements for systemic levels and investigation into alternative respiratory sample matrices [0.03%]
基于呼吸样本矩阵中的短链脂肪酸作为系统水平替代测量的评估及进一步研究替代呼吸样本矩阵的研究
Christopher Green,Joycelyn Bempong,Marilyn Ly Ong et al.
Christopher Green et al.
Short-chain fatty acids (SCFAs) are metabolic by-products from microbial fermentation of complex carbohydrates and protein. They have gained clinical interest for their protective effects, including within the lung microenvironment. SCFAs a...
Glutamine alleviates immunosuppression in polymicrobial sepsis by augmenting bacterial phagocytosis through sustaining the GFAT-DRP1 dependent mitochondrial calcium dynamics [0.03%]
谷氨酰胺通过维持GFAT-DRP1依赖的线粒体钙动态来增强细菌吞噬作用，从而缓解脓毒症中的免疫抑制现象
Yuanfeng Zhu,Xiaoli Chen,Lin Xia et al.
Yuanfeng Zhu et al.
Sepsis triggers impaired macrophage bacterial phagocytosis, rendering the host more vulnerable to secondary infections, a manifestation termed sepsis-associated immunosuppression. Glutamine is a vital nutrient in critical illness that not o...
Blood Pressure Reduction and Anti-inflammatory Macrophage Augmentation Attenuate Uterine Immune Dysregulation and Inflammation in Mice with Salt-Sensitive Hypertension [0.03%]
盐敏感性高血压小鼠血压降低和抗炎型巨噬细胞增多可减轻子宫免疫功能障碍和炎症反应
Shobana Navaneethabalakrishnan,Bethany L Goodlett,Hannah L Smith et al.
Shobana Navaneethabalakrishnan et al.
Salt-sensitive hypertension (SSHTN) promotes systemic inflammation, pro-inflammatory immune cell infiltration, and end-organ damage, including in the kidneys and gonads. However, its impact on uterine immune cell populations remains unclear...
Role of conventional dendritic cells in schistosomiasis-induced pulmonary hypertension [0.03%]
常规树突状细胞在血吸虫病诱导的肺动脉高压中的作用
Claudia Mickael,Rahul Kumar,Dara C Fonseca Balladares et al.
Claudia Mickael et al.
Background: Schistosomiasis is a major cause of pulmonary hypertension (PH) worldwide, and CD4 T cells are critical in disease pathogenesis. The role of dendritic cells (DCs) in Schistosoma-induced PH (SchPH) is unknown. ...
Macrophage plasticity and glucose metabolism: the role of immunometabolism in pulmonary arterial hypertension [0.03%]
巨噬细胞的可塑性和葡萄糖代谢：免疫代谢在肺动脉高压中的作用
Lindsay Jefferson,Patricia D A Lima,Stephen L Archer
Lindsay Jefferson
Pulmonary arterial hypertension (PAH) is a syndrome characterized by a mean pulmonary artery pressure >20 mmHg and elevated pulmonary vascular resistance >2 Wood Units in the absence of left heart disease, chronic lung disease or hypoxia, a...
Physiological roles of phosphoinositides and inositol phosphates: Implications for metabolic dysfunction-associated steatotic liver disease [0.03%]
磷脂酸肌醇和肌醇磷酸的生理作用：对代谢功能障碍相关肝脂肪变性疾病的影响
Zhili Cheng,Magdalene K Montgomery
Zhili Cheng
Phosphoinositides and inositol phosphates (IPs) are integral to numerous cellular processes, including membrane trafficking, signal transduction and calcium dynamics. These lipid-derived signalling mediators orchestrate the spatial and temp...
Double-edged mitophagy: balancing inflammation and resolution in lung disease [0.03%]
双刃面的线粒体自噬：在肺部疾病中平衡炎症和消退反应
Sijia Tian,Yingyi Zhang,Chuanchuan Liu et al.
Sijia Tian et al.
Inflammatory lung diseases, such as chronic obstructive pulmonary disease (COPD), acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), and asthma, are driven by mitochondrial dysfunction and aberrant immune responses, yet the...
TSPAN4 controls vascular smooth muscle cell phenotypic switching and intimal hyperplasia by targeting TPM1-regulated cytoskeletal organization [0.03%]
TSPAN4通过靶向TPM1调节的细胞骨架组织控制血管平滑肌细胞表型转换和内膜增生
Shengbiao Li,Kexin Chen,Yi Zhang et al.
Shengbiao Li et al.
Vascular smooth muscle cell (VSMC) phenotypic switching, followed by enhanced proliferation and migration, is a key event in the development of intimal hyperplasia in diverse vascular diseases. While tetranspanin 4 (TSPAN4) is known to be e...
SUL-138 mitigates accelerated endothelial aging and protects the kidney [0.03%]
SUL-138可减轻内皮细胞衰老并保护肾脏功能
Annika A Jüttner,Sabrina Ribeiro Gonsalez,Martijn van Heugten et al.
Annika A Jüttner et al.
Vascular aging is marked by increased levels of reactive oxygen species in endothelial cells. Reactive oxygen species can amongst others be produced by dysfunctional mitochondria, contributing to acceleration of vascular aging by promoting ...