O-GlcNAc Modification of CaMKII-Mediated Mitophagic Flux Regulation via HSPB8 in Diabetic Cardiomyopathy [0.03%]
糖尿病心肌病中HSPB8介导的O-GlcNAc修饰调节线粒体自噬通量中的CaMKII作用
Yanjuan Jiang,Kaibo Hu,Zhaowei Luo et al.
Yanjuan Jiang et al.
In the diabetic heart, hyperglycemia can augment the covalent modification of Ca2+-calmodulin-dependent protein kinaseII (CaMKII) by O-linked N-acetylglucosamine (O-GlcNAc). Concurrently, mitophagy serves as a crucial link in diabetic myoca...
Multifaceted roles of Isthmin-1 in health and disease: mechanism and therapeutic intervention [0.03%]
Isthmin-1在健康和疾病中的多重作用：机制与治疗干预
Yuting Wei,Wenqi Wu,Yanli Hou et al.
Yuting Wei et al.
Isthmin-1 (ISM1) is a secreted protein with multiple functions, containing a thrombospondin type 1 repeat domain and an AMOP domain. The initial studies mainly involved growth and development, metabolism, and tumor invasion. Numerous studie...
Harnessing liver-heart crosstalk via extracellular vesicle-mediated hepatic delivery of microRNAs for cardiac repair [0.03%]
利用外泌体介导的微小RNA肝递送激活肝心对话以促进心脏修复
Ji-Young Kang,Dasom Mun,Gyeongseo Yoo et al.
Ji-Young Kang et al.
Extracellular vesicles (EVs) hold great potential to deliver microRNAs (miRNAs) in vivo; however, its preferential hepatic accumulation after systemic administration hinders the therapeutic efficacy of miRNAs. Inter-organ communication via ...
Translational uncoupling of renin synthesis and activity reveals a mechanism of kidney vascular remodeling [0.03%]
肾素合成和活性的翻译解耦揭示肾脏血管重塑的机制
Silvia Medrano,Lucas Ferreria de Almeida,Zheng Zhao et al.
Silvia Medrano et al.
Chronic inhibition of the renin-angiotensin-aldosterone system (RAAS) causes progressive renal vascular disease characterized by concentric arterial and arteriolar hypertrophy (CAAH), driven by sustained activation of renin-producing cells....
The role of central regulators in lipid hydroperoxide-mediated muscle atrophy. Exploring mechanisms beyond ferroptosis [0.03%]
中央调节因子在脂质氢过氧化物介导的肌肉萎缩中的作用。探索铁死亡之外的机制
Hiroaki Eshima
Hiroaki Eshima
The oxidation of lipids in biological systems generates lipid hydroperoxides, which are implicated in cellular dysfunction, such as arteriosclerosis and cognitive decline. Although multiple lipid species, including phospholipids, ceramides,...
Pertussistoxin as well as Staphylococcal superantigen induce glycolysis as energy source during T cell activation in an adenoid organoid model [0.03%]
百日咳毒素及金黄色葡萄球菌超抗原在咽扁桃体器官样模型中诱导T细胞活化并作为糖酵解能量来源的作用机制研究
Klaus Tenbrock,Christopher T Neullens,Christian Kühne et al.
Klaus Tenbrock et al.
Bystander activation represents an innate-like mechanism by which T cells, particularly effector and memory subsets, can become activated in the absence of cognate antigen recognition. Using human tonsil organoid cultures as a physiological...
Thymosin β4 alleviates sepsis-associated acute kidney injury by suppressing MAPK signaling pathway [0.03%]
胸腺素β4通过抑制MAPK信号途径缓解脓毒症相关急性肾损伤
Xiaojun Ouyang,Zhiyuan Long,Xiaodan Xu et al.
Xiaojun Ouyang et al.
Sepsis-associated acute kidney injury (SA-AKI) is a common complication in septic patients and is associated with high mortality and progression to chronic kidney disease (CKD). Previous studies have demonstrated that thymosin β4 (Tβ4) at...
Edaravone Dexborneol regulates the endothelial PPARγ-PON1 axis to inhibit high-cholesterol-induced atherosclerosis [0.03%]
edaravone-dexborneol调节内皮PPARγ-PON1轴抑制高胆固醇诱导的动脉粥样硬化
Fengming Guo,Yuxin Liu,Wenjun Qiu et al.
Fengming Guo et al.
Atherosclerosis, a primary cause of ischemic diseases, is driven by excessive oxidative stress. Edaravone Dexborneol, a clinically used antioxidant, has demonstrated potent protective effects in cerebral ischemia. However, its role in ather...
HDAC9 promotes atherosclerosis by suppressing CYP7A1 and impairing hepatic cholesterol excretion [0.03%]
组蛋白脱乙酰酶9通过抑制CYP7A1而促进动脉粥样硬化的发展及其对肝脏胆固醇外排的影响作用研究
Rongzhan Lin,Mingjue Li,Jichen Liu et al.
Rongzhan Lin et al.
Histone deacetylase 9 (HDAC9) exacerbates atherosclerosis through inflammatory pathways, yet its specific role in cholesterol metabolism remains to be fully elucidated. Here, we investigated whether HDAC9 promotes atherosclerosis by impairi...
Clusterin ameliorates LPS-induced ARDS by inhibiting the Wnt/β-catenin pathway [0.03%]
_clusterin通过抑制Wnt/β-catenin信号通路改善LPS诱导的ARDS
Rui Tang,Wen Tang,Hao Hu et al.
Rui Tang et al.
Acute Respiratory Distress Syndrome (ARDS) is a critical illness characterized by endothelial barrier damage, and this study investigates the specific role of clusterin (CLU). The study found that CLU concentrations were significantly lower...