Tolerogenic dendritic cells immunotherapy protects against IgA nephropathy [0.03%]
耐受性树突状细胞免疫疗法保护IgA肾病不受损害
Xiaohong Zheng,Hao Yang,Juan Jiang et al.
Xiaohong Zheng et al.
This study aimed to investigate the therapeutic efficacy of tolerogenic dendritic cells (tolDCs) in IgA nephropathy (IgAN) mice. Male C57BL/6 mice were used to construct an IgAN model via oral mucosal immunization, while tolDCs were generat...
Dysregulated iron metabolism associates with neutrophilic airway inflammation in COPD [0.03%]
铁代谢紊乱与慢性阻塞性肺病的中性粒细胞气道炎症相关
James Baker,Andrew Higham,Christopher McCrae et al.
James Baker et al.
Pulmonary iron levels are increased in COPD, possibly due to increased red blood cell leakage from the microvasculature. Neutrophils cause endothelial cell damage which may cause vascular dysfunction and iron dysregulation in COPD. We inves...
Beyond αβ T cells: unlocking the potential of diverse immune cells in CAR modification [0.03%]
αβT细胞之外：解锁CAR修饰多样免疫细胞的潜力
Yangyang Gao,Feifei Guo,Min Li et al.
Yangyang Gao et al.
Chimeric antigen receptor (CAR) T cell therapy has emerged as a groundbreaking advancement in cancer immunotherapy, demonstrating remarkable success in treating hematologic malignancies. However, its application in solid tumors remains chal...
Sex-dependent differences in the progression of renal injury and fibrosis following ischemic acute kidney injury [0.03%]
缺血性急性肾损伤后肾损伤和纤维化进展的性别差异
Sharon D Ricardo,Tingfang Zhang,Zoe McArdle et al.
Sharon D Ricardo et al.
Sex differences critically influence the renal response to ischemic injury, yet the mechanisms underlying differing recovery between males and females remain incompletely understood. Using a unilateral ischemia-reperfusion model with contra...
Site-1 Protease-Derived sPRR Contributes to Renal Ischemia-Reperfusion Injury in Mice by Promoting Macrophage Classical Activation [0.03%]
小鼠肾缺血再灌注损伤中sPRR通过促进巨噬细胞经典活化发挥促炎作用
Tianxin Yang,Ye Feng,Huaqing Zheng et al.
Tianxin Yang et al.
Soluble (pro)renin receptor (sPRR), the product of site-1 protease (S1P)-mediated cleavage of PRR, has emerged as an important player in the physiological and pathophysiological processes in the kidney. However, a potential role of S1P-deri...
Evaluation of inflammation-mediated cancer progression during FLASH and conventional irradiation-induced lung injury [0.03%]
线性加速器受照和常规照射诱导的肺损伤期间炎症介导的癌症进展评估
Hui Luo,Chengliang Yang,Dan Hu et al.
Hui Luo et al.
Radiation-induced inflammatory responses are known to contribute to lung injury, but how these responses occur under ultra-high dose rate FLASH irradiation (FLASH) remains poorly characterized. This study aimed to compare inflammation-media...
Loss of ATF3 Exacerbates Pulmonary Fibrosis via Enhanced Neutrophil Recruitment and Profibrotic Macrophage Polarization [0.03%]
ATF3缺失通过增强中性粒细胞募集和促纤维化巨噬细胞极化加重肺纤维化
Se-Hyang Hong PhD,Binna Yun,Suyeon Cho et al.
Se-Hyang Hong PhD et al.
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by irreversible scarring, excessive extracellular matrix (ECM) deposition, and progressive loss of pulmonary function. Although innate immune cells...
Disrupted Renal Clock and Blood Pressure Rhythms in Type 2 Diabetic Nephropathy [0.03%]
2型糖尿病肾病中受损的肾脏生物钟和血压节律
Biyang Xu,Marharyta Semenikhina,Ratnakar Tiwari et al.
Biyang Xu et al.
Type 2 diabetes mellitus (T2DM), accounting for approximately 90% of adult-onset diabetes cases, is a major risk factor for diabetic kidney disease (DKD). Emerging evidence has linked T2DM with disrupted circadian rhythms. However, its role...
DIETARY AND MICROBIAL INFLUENCES ON INTESTINAL IMMUNE ACTIVATION IN TREATED PEOPLE LIVING WITH HIV AND A TH17-DEFICIENT MOUSE MODEL [0.03%]
HIV感染个体及TH17缺陷小鼠肠道免疫活化的饮食及微生物影响研究
Francisco Illanes-Álvarez,Denisse Márquez-Ruiz,Irene Campaña-Gómez et al.
Francisco Illanes-Álvarez et al.
The objectives of this work were to analyze intestinal microbiota, barrier integrity, and inflammatory/immune markers in long-term virally suppressed people living with HIV (PLWH) with high CD4+ T cells counts, and to evaluate the influence...
Persistent DNA methylation and downregulation of homeostatic genes in astrocytes after pilocarpine-induced status epilepticus: Implications for epileptogenesis [0.03%]
胆碱盐酸盐诱导的癫痫持续状态后星形胶质细胞DNA甲基化和稳态基因低表达的长期变化及其与痫性发作发生的关系
Dante Gomez Cuautle,Alicia Rossi,Milton Paul Marquez Cadena et al.
Dante Gomez Cuautle et al.
Epilepsy is a debilitating neurological disorder characterized by recurrent seizures, affecting millions of patients worldwide. Retrospective studies in Temporal lobe epilepsy (TLE) patients have shown a high incidence of an initial precipi...