Inhibition of Protein Arginine Methyltransferase 5 attenuates Dialysis-Related Peritoneal Fibrosis via Suppression of Angiogenesis and Inflammatory State [0.03%]
蛋白精氨酸甲基转移酶5抑制通过抗血管生成和抗炎作用缓解透析相关腹膜纤维化
Jinqing Li,Yingfeng Shi,Hui Chen et al.
Jinqing Li et al.
Dialysis-related peritoneal fibrosis (PF) is a complication of peritoneal dialysis (PD) that leads to ultrafiltration failure and poor technique survival. Currently, no effective therapeutic strategies are available for PF. Protein Arginine...
Glomerulus-Targeted Nanotherapy via Collagen IV-α3 Binding Enhances Renal Immunoregulation in Lupus Nephritis [0.03%]
靶向胶原IV-α3的纳米治疗通过针对肾小球来增强狼疮性肾炎的免疫调节作用
Lei Wang,Eleni Markoutsa,Rajkumar Venkatadri et al.
Lei Wang et al.
Lupus nephritis requires long-term immunosuppressive therapy, which is often associated with severe systemic side effects. Therefore, new therapeutic strategies that maintain high efficacy while minimizing adverse effects is essential. Alth...
A Novel tsRNA, 5'tiRNA-GluCTC, Mediates Cardiomyocyte-Fibroblast Crosstalk to Promote Cardiac Fibrosis in Restrictive Cardiomyopathy [0.03%]
一种新型tsRNA 5'tiRNA-GluCTC介导心肌细胞-成纤维细胞交叉对话以促进限制性心肌病心脏纤维化
Jie Tian,Xiaohui Xu,Xiaoli Yan et al.
Jie Tian et al.
Restrictive cardiomyopathy (RCM) is characterized by pronounced cardiac fibrosis, leading to ventricular stiffening and diastolic dysfunction. While cardiomyocyte mutations are known triggers, the mechanisms initiating pro-fibrotic signalin...
Combined administration of fructooligosaccharides and Clostridium butyricum attenuates bowel cleansing-induced dysbiosis and safeguards mucosal defense in a murine model [0.03%]
低聚果糖联合丁酸梭菌减轻肠道清洁引起的菌群失调并保护小鼠黏膜屏障功能
Xinyu Xu,Mingxia Zhou,Ruoqi Zhang et al.
Xinyu Xu et al.
Bowel preparation with polyethylene glycol electrolyte solution (PEG-ELS) is indispensable for gastrointestinal endoscopy and related procedures. However, it disrupts gut microbial homeostasis and increases host vulnerability to ensuing inf...
O-GlcNAc Modification of CaMKII-Mediated Mitophagic Flux Regulation via HSPB8 in Diabetic Cardiomyopathy [0.03%]
糖尿病心肌病中HSPB8介导的O-GlcNAc修饰调节线粒体自噬通量中的CaMKII作用
Yanjuan Jiang,Kaibo Hu,Zhaowei Luo et al.
Yanjuan Jiang et al.
In the diabetic heart, hyperglycemia can augment the covalent modification of Ca2+-calmodulin-dependent protein kinaseII (CaMKII) by O-linked N-acetylglucosamine (O-GlcNAc). Concurrently, mitophagy serves as a crucial link in diabetic myoca...
Multifaceted roles of Isthmin-1 in health and disease: mechanism and therapeutic intervention [0.03%]
Isthmin-1在健康和疾病中的多重作用：机制与治疗干预
Yuting Wei,Wenqi Wu,Yanli Hou et al.
Yuting Wei et al.
Isthmin-1 (ISM1) is a secreted protein with multiple functions, containing a thrombospondin type 1 repeat domain and an AMOP domain. The initial studies mainly involved growth and development, metabolism, and tumor invasion. Numerous studie...
Harnessing liver-heart crosstalk via extracellular vesicle-mediated hepatic delivery of microRNAs for cardiac repair [0.03%]
利用外泌体介导的微小RNA肝递送激活肝心对话以促进心脏修复
Ji-Young Kang,Dasom Mun,Gyeongseo Yoo et al.
Ji-Young Kang et al.
Extracellular vesicles (EVs) hold great potential to deliver microRNAs (miRNAs) in vivo; however, its preferential hepatic accumulation after systemic administration hinders the therapeutic efficacy of miRNAs. Inter-organ communication via ...
Translational uncoupling of renin synthesis and activity reveals a mechanism of kidney vascular remodeling [0.03%]
肾素合成和活性的翻译解耦揭示肾脏血管重塑的机制
Silvia Medrano,Lucas Ferreria de Almeida,Zheng Zhao et al.
Silvia Medrano et al.
Chronic inhibition of the renin-angiotensin-aldosterone system (RAAS) causes progressive renal vascular disease characterized by concentric arterial and arteriolar hypertrophy (CAAH), driven by sustained activation of renin-producing cells....
The role of central regulators in lipid hydroperoxide-mediated muscle atrophy. Exploring mechanisms beyond ferroptosis [0.03%]
中央调节因子在脂质氢过氧化物介导的肌肉萎缩中的作用。探索铁死亡之外的机制
Hiroaki Eshima
Hiroaki Eshima
The oxidation of lipids in biological systems generates lipid hydroperoxides, which are implicated in cellular dysfunction, such as arteriosclerosis and cognitive decline. Although multiple lipid species, including phospholipids, ceramides,...
Pertussistoxin as well as Staphylococcal superantigen induce glycolysis as energy source during T cell activation in an adenoid organoid model [0.03%]
百日咳毒素及金黄色葡萄球菌超抗原在咽扁桃体器官样模型中诱导T细胞活化并作为糖酵解能量来源的作用机制研究
Klaus Tenbrock,Christopher T Neullens,Christian Kühne et al.
Klaus Tenbrock et al.
Bystander activation represents an innate-like mechanism by which T cells, particularly effector and memory subsets, can become activated in the absence of cognate antigen recognition. Using human tonsil organoid cultures as a physiological...