BMP4 signaling regulates the expression of signals and transcription factors for coordinated cytodifferentiation in the murine ureter [0.03%]
BMP4信号调节小鼠输尿管协同细胞分化所需的信号和转录因子的表达
Lena Deuper,Nicolas Hense,Anja Beckers et al.
Lena Deuper et al.
Mutations in BMP4 have been associated with malformations of the urinary tract in human patients. Genetic studies in mice have shown that these defects are linked to the expression of Bmp4 in the mesenchymal primordium of the ureter, where ...
Combination amino acids and glucose effects on insulin and GLP-1 secretion [0.03%]
氨基酸和葡萄糖联合对胰岛素及GLP-1释放的影响
Kenneth H C Koh,Junhe Zhao,Sarah X Luo et al.
Kenneth H C Koh et al.
Dietary nutrients such as amino acids possess an insulinogenic effect. However, not all amino acids were meticulously investigated for their effect on both insulin and incretin secretion, and the effect of amino acids given in different com...
Revisiting RAS family GTPase signaling: effector selectivity and oncogenic bypass [0.03%]
重新审视RAS家族GTP酶信号传导：效应器选择性和致癌旁路作用
Dhirendra K Simanshu,Frank McCormick
Dhirendra K Simanshu
Distinct effector-binding preferences among RAS family GTPases challenge the longstanding view that canonical RAS proteins uniformly bind and activate RAF, PI3Kα, RalGDS, and other downstream effectors. Quantitative binding data, supported...
Yoshinori Takahashi,David M Opozda,Hong-Gang Wang
Yoshinori Takahashi
Autophagy delivers cytoplasmic materials to lysosomes, supporting protein and organelle quality control as well as nutrient recycling to maintain cellular homeostasis. A defining feature of macroautophagy, the major form of autophagy, is th...
Histone modification cross-talk: analytical tools and molecular mechanisms [0.03%]
组蛋白修饰互作分析工具与分子机制研究
Jennifer Jiang,Sarah DuBois-Coyne,Eunju Nam et al.
Jennifer Jiang et al.
Chromatin function emerges from combinatorial patterns of histone post-translational modifications (PTMs) that are read, written, and erased by dedicated enzymes. Over the past 30 years, increasing evidence suggests that specific histone PT...
Functional interaction surfaces of the bacterial transcription terminator Rho are required for the interactions with the elongation factor NusG [0.03%]
Rho转录终止子与伸长因子NusG相互作用的结构基础
Abhijeet Behera,Passong Immanual R Chhakchhuak,Sriyans Jain et al.
Abhijeet Behera et al.
Transcription terminator Rho interacts with the elongation factor NusG to induce efficient termination. By employing random mutagenesis, structure-guided site-directed mutagenesis, and phenotypic re-evaluations of our laboratory mutants, we...
Influence of SmpB and ClpX interactions and interactomes on the transcription profile of Mycobacterium tuberculosis [0.03%]
SmpB和ClpX相互作用及其互作蛋白对结核杆菌转录组的影响
Ashish Deshmukh,Sidra Khan,Amit Chakraborty et al.
Ashish Deshmukh et al.
SmpB is a key regulator of trans-translation in bacteria. The interactome of Mycobacterium tuberculosis (Mtb) ClpX revealed SmpB alongside multiple transcriptional regulators and sigma factors that can alter the transcriptional profile. The...
Mahalashmi Srinivasan,Akhil Patel,Tark Patel et al.
Mahalashmi Srinivasan et al.
Tau aggregation is a key pathological feature of neurodegenerative diseases termed tauopathies. Identifying the various cellular factors that function to prevent tau aggregation in cells can generate key insights into how to mitigate diseas...
Use of hydrogen deuterium exchange mass spectrometry in tandem with modern structural biology [0.03%]
与现代结构生物学相结合的氢氘交换质谱法的应用
Hunter G Nyvall,Alexandria L Shaw,Emma E Walsh et al.
Hunter G Nyvall et al.
Hydrogen-deuterium exchange mass spectrometry (HDX-MS) is an established technique that measures the exchange rate of amide hydrogens, with this exchange rate being a surrogate for protein conformational dynamics. Advances in instrumentatio...
Stefanie J Hodapp,Gerard Manning,Alexandra C Newton
Stefanie J Hodapp
Protein kinase C (PKC) is a family of serine/threonine kinases whose nine members play central roles in signal transduction, regulating key cellular processes such as proliferation, migration, differentiation, and apoptosis. PKC theta (θ) ...