Bioinformatic assessment of the potential amyloidogenicity of the human and evolutionarily more ancient proteomes [0.03%]
人类和进化上较为古老的蛋白质组的潜在淀粉样蛋白性质的生物信息学评估
Douglas B Kell,Ivayla Roberts,Xiaomian Tan et al.
Douglas B Kell et al.
AmyloGram is a computer program that uses n-gram encoding and a random forest classifier to produce a numerical score between 0 and 1 for the predicted amyloidogenicity of a given protein sequence. In a variety of recent studies we have use...
The RNA exosome co-factor CTEXT exists as an independent multiprotein complex in Saccharomyces cerevisiae [0.03%]
酿酒酵母中的RNA外切酶辅助因子CTEX作为一个独立的多蛋白复合物存在
Rajlaxmi Gaine,Satarupa Das,Biswadip Das
Rajlaxmi Gaine
In Saccharomyces cerevisiae, the CTEXT (CBC-Tif4631-dependent Exosomal Targeting) complex, consisting of Cbc1/2, Tif4631, Upf3, and Dbp2, defines a novel cofactor of the nuclear RNA exosome promoting the degradation of two distinct classes ...
Functional Divergence and Conservation in the QueC Protein Family (PF06508): From tRNA Modification to Anti-Phage Defense [0.03%]
QueC蛋白家族（PF06508）的功能分化与保守性：从tRNA修饰到抗噬菌体防御
Kaitlynn Libby,Crista Calia,Rahul Benda et al.
Kaitlynn Libby et al.
The QueC protein family (PF06508) is best known for its role in the biosynthesis of 7‑deazaguanine derivatives, including the tRNA modification queuosine and the DNA base 7‑cyano-7‑deazaguanine (preQ0). Recent discoveries, however, revea...
Brígida R Pinho,Michael R Duchen,Jorge M A Oliveira
Brígida R Pinho
Mitophagy is a crucial autophagic process that degrades dysfunctional or unnecessary mitochondria, thereby maintaining cellular homeostasis. Mitophagy occurs through both basal mitophagy and stress-induced pathways, highly regulated by a co...
Defining Active Conformations from Substrate-Bound Structures Enables Active-State AlphaFold2 Modeling of All 437 Human Catalytic Protein Kinase Domains [0.03%]
基于底物结合结构定义活性构象可助力AlphaFold2模拟人类所有437个催化型蛋白激酶结构域的活性状态
Joan Gizzio,Bulat Faezov,Qifang Xu et al.
Joan Gizzio et al.
Humans have 437 catalytically competent protein kinase domains with a typical kinase fold resembling Protein Kinase A. The active form of a kinase must satisfy requirements for binding ATP, magnesium, and substrate. From structural bioinfor...
An S752D activation loop mutation dynamically primes Muscle-Specific Kinase (MuSK) for activation [0.03%]
S752D活化环突变动态激活肌肉特异性激酶(MuSK)
Jakob J Prömer,James W Murphy,Mark A Lemmon et al.
Jakob J Prömer et al.
Muscle-specific kinase (MuSK) is a receptor tyrosine kinase essential for neuromuscular junction (NMJ) formation and maintenance, yet its regulation remains poorly understood. Crystallographic studies of wild-type MuSK revealed an autoinhib...
Non-canonical and constitutive activation of small GTPases: more than an exception to the rule? [0.03%]
非规范和组成型的小G蛋白激活：规则之上的例外吗？
Jasmine Kiers,Peter L Hordijk
Jasmine Kiers
The superfamily of small GTPases comprises over 150 members, clustered in different families (e.g., Ras, Rab, Rho), that together are essential for a wide range of cellular functions. Most GTPases behave as molecular on/off switches, with r...
The expanding role of protease therapeutics (2012-2026): from replacement therapies to immune system modulation and beyond [0.03%]
不断扩大的蛋白酶药物角色（2012-2026）：从替代疗法到免疫系统调节等其他方面
Sage E Nelson,Samantha G Martinusen,Raymond Pho et al.
Sage E Nelson et al.
Proteases are powerful therapeutic agents, offering unique advantages over conventional small molecules and biologics through their ability to directly and precisely cleave and (de)activate their protein targets. Since the early 1990s, FDA-...
Retraction: A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells [0.03%]
撤稿：碳酸酐酶IX具有非催化功能，可促进人乳腺癌细胞的糖酵解表型和pH调节
Susan Frost,Mam Y Mboge,Zhijuan Chen et al.
Susan Frost et al.
Retraction: A new Mad2-interacting domain of Cdc20 is critical for the function of Mad2-Cdc20 complex in the spindle assembly checkpoint [0.03%]
撤稿：Cdc20中与Mad2相互作用的新区城对Mad2-Cdc20复合体在纺锤体组装检验点中的功能至关重要
Susanta Roychoudhury,Gourish Mondal,Rathindra N Baral
Susanta Roychoudhury