Protein S: a vitamin K-dependent factor bridging haemostasis, tissue homeostasis and cancer [0.03%]
蛋白S：一种连接止血、组织稳态和癌症的维生素K依赖因子
Omar Benzakour,Yousra Kaissouni,Olivier E Pardo et al.
Omar Benzakour et al.
Protein S (PROS1) is a vitamin K-dependent plasma glycoprotein that was originally described as a non-enzymatic cofactor of activated protein C in the regulation of blood coagulation. Over the past three decades, PROS1 has emerged as a plei...
Reshaping the glycocalyx: the SULF extracellular endosulfatases as molecular editors of heparan Sulfate [0.03%]
重塑糖萼：SULF胞外内磺酸酶作为肝素硫酸盐的分子编辑器
Rebecca-Joe Boustany,Sylvain D Vallet,Yara Awad et al.
Rebecca-Joe Boustany et al.
Heparan sulfate proteoglycans are central modulators of cell-cell communication, largely through the information encoded in their sulfation patterns. Among extracellular regulators of this 'heparan sulfate code', the endosulfatases SULF1 an...
Mechanistic insights into acetylated histone recognition by the CECR2 bromodomain [0.03%]
CECR2溴结构域识别乙酰化组蛋白的机制见解
Soumyajit Chakraborty,Anirban Roy,Smrutimayee Prusty et al.
Soumyajit Chakraborty et al.
Chromatin remodeling regulator CECR2 plays critical roles in neurulation, spermatogenesis, DNA damage response, and cancer metastasis, yet the structural determinants underlying its recognition of acetylated histones remain poorly understoo...
Nanobodies against Plasmodium adhesins that block receptor engagement and malaria parasite invasion [0.03%]
针对疟原虫粘附蛋白的纳米抗体可阻断受体结合和疟疾寄生虫入侵
Jaison D Sa,Jill Chmielewski,Amy Adair et al.
Jaison D Sa et al.
Malaria is caused by Plasmodium parasites, and its clinical symptoms are a result of parasite invasion of red blood cells and the subsequent cycles of replication and proliferation. In human populations, Plasmodium vivax is responsible for ...
Persistence without turnover: the RhoG G12E mutant highlights the role of nucleotide cycling in RhoG signaling [0.03%]
持续而不转染RhoG G12E突变体凸显核苷酸循环在RhoG信号传导中的作用
Shah Wajed,Yann Ferrandez,Mahel Zeghouf et al.
Shah Wajed et al.
Small GTPases of the Ras superfamily act as molecular switches cycling between GDP-bound inactive and GTP-bound active states. Their signaling output depends not only on GTP loading but on continuous nucleotide cycling controlled by GEFs an...
Alternative Splicing of Rice Chloroplastic CuZn Superoxide Dismutase, OsCSD2: Impact on expression and protein characteristics [0.03%]
水稻叶绿体Cu/Zn超氧化物歧化酶OsCSD2的可变剪接：对表达和蛋白特性的影响
Ravi Prakash Sanyal,Vishal Prashar,Ramanjulu Sunkar et al.
Ravi Prakash Sanyal et al.
Superoxide dismutases (SODs) are involved in cellular reactive oxygen species (ROS) homeostasis under diverse conditions. Among different plant SODs, CuZnSODs (CSDs) are most abundant and localized to multiple compartments, including chloro...
Difference and similarity between the ubiquitous secretory pathway Ca2+-ATPases, SERCA2b, and SPCA1a [0.03%]
SERCA2b与SPCA1a的异同点分析
Yuxia Zhang,Kenji Inaba
Yuxia Zhang
P1B-type and P2-type ATPases play fundamental roles in maintaining intracellular metal ion homeostasis, which is essential for various cellular processes including protein folding, trafficking and signaling. SERCA2b, a member of the P2A-typ...
A molecular perspective on dimethylarginine dimethylaminohydrolases structure and function [0.03%]
从分子角度分析二甲基精氨酸二甲胺水解酶的结构和功能
Luana Ruta,Mirco Dindo,Ilaria Bellezza et al.
Luana Ruta et al.
Nitric oxide (NO) is a central signaling molecule that regulates vascular tone, neurotransmission, and immune function. NO production from L-arginine by nitric oxide synthase (NOS) must be tightly controlled, as excess NO contributes to oxi...
Nataliia Nechytailo,Karolina Szczepanowska
Nataliia Nechytailo
The mitochondrial oxidative phosphorylation (OXPHOS) system consists of multimeric, highly ordered protein complexes critical for energy production and metabolic wiring in the cell. Recent discoveries in mitochondrial proteolysis, facilitat...
VDR/RXR antagonizes calcineurin-activated NFAT1, an essential regulator of Coronin-1A expression and Mycobacterial persistence [0.03%]
VDR / RXR 抗阻钙调神经磷酸酶激活的 NFAT1，这是冠状病毒 1A 表达和分枝杆菌持续存在的必要调节器
Sayantani Datta,Arnab Hazra,Payel Das et al.
Sayantani Datta et al.
Coronin-1A (CORO1A), a conserved WD-repeat protein enriched in immune cells, plays a pivotal role in host-pathogen interactions and immune regulation, yet the mechanisms controlling its expression have remained elusive. We identify Vitamin ...