Structure-based enzyme engineering improves donor-substrate recognition of Arabidopsis thaliana glycosyltransferases [0.03%]
基于结构的酶工程技术改善了拟南芥糖基转移酶对供体底物的认识
Aishat Akere,Serena H Chen,Xiaohan Liu et al.
Aishat Akere et al.
Glycosylation of secondary metabolites involves plant UDP-dependent glycosyltransferases (UGTs). UGTs have shown promise as catalysts in the synthesis of glycosides for medical treatment. However, limited understanding at the molecular leve...
Yasuhiro Onogi,Ahmed Elagamy Mohamed Mahmoud Khalil,Siegfried Ussar
Yasuhiro Onogi
Adipose tissue is a central regulator of metabolism and an important pharmacological target to treat the metabolic consequences of obesity, such as insulin resistance and dyslipidemia. Among the various cellular compartments, the adipocyte ...
Sarah Justesen,Kirsten V Haugegaard,Jacob B Hansen et al.
Sarah Justesen et al.
Exposure to cold alters glucose and lipid metabolism of white and brown adipose tissue via activation of β-adrenergic receptor (ADRB). Fibroblast growth factor 21 (FGF21) has been shown to be locally released from adipose tissue upon activ...
MAPK-interacting kinase 2 (MNK2) regulates adipocyte metabolism independently of its catalytic activity [0.03%]
无酶活性的丝裂原活化蛋白激酶互作蛋白激酶2调节脂肪细胞代谢
James E Merrett,Jianling Xie,Peter J Psaltis et al.
James E Merrett et al.
The mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are serine/threonine protein kinases that are activated by the ERK1/2 (extracellular regulated kinase) and p38α/β MAPK pathways. The MNKs have previously been implicat...
Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases [0.03%]
光学纯度分离、体外活性测试和有机磷中毒胆碱酯酶再活化三作用再生剂的结构特征研究
Nikola Maraković,Anamarija Knežević,Igor Rončević et al.
Nikola Maraković et al.
The enantiomers of racemic 2-hydroxyimino-N-(azidophenylpropyl)acetamide-derived triple-binding oxime reactivators were separated, and tested for inhibition and reactivation of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in...
Merkel cell polyomavirus small tumour antigen activates the p38 MAPK pathway to enhance cellular motility [0.03%]
Merkel细胞多瘤病毒的小肿瘤抗原活化p38 MAPK通路以增强细胞运动性
Samuel J Dobson,Anthony Anene,James R Boyne et al.
Samuel J Dobson et al.
Merkel cell carcinoma (MCC) is an aggressive skin cancer with high rates of recurrence and metastasis. Merkel cell polyomavirus (MCPyV) is associated with the majority of MCC cases. MCPyV-induced tumourigenesis is largely dependent on the e...
Dissecting capture and twisting of aureolysin and pseudolysin: functional amino acids of the Dispase autolysis-inducing protein [0.03%]
分解和扭曲aureolysin和pseudolysin：Dispase自溶诱导蛋白功能氨基酸的分析
David Fiebig,Anita Anderl,Sahra Al Djaizani et al.
David Fiebig et al.
The Dispase autolysis-inducing protein (DAIP) from Streptomyces mobaraensis attracts M4 metalloproteases, which results in inhibition and autolysis of bacillolysin (BL) and thermolysin (TL). The present study shows that aureolysin (AL) from...
Cr(VI)-induced overactive mitophagy contributes to mitochondrial loss and cytotoxicity in L02 hepatocytes [0.03%]
六价铬诱导的过度线粒体自噬导致L02肝细胞线粒体丧失和细胞毒性
Yujing Zhang,Huanfeng Bian,Yu Ma et al.
Yujing Zhang et al.
Hexavalent chromium [Cr(VI)] has aroused the main interest of environmental health researchers due to its high toxicity. Liver is the main target organ of Cr(VI), and the purpose of this study was to explore whether mitophagy contributes to...
Alessandra Casamento,Emmanuel Boucrot
Alessandra Casamento
Endocytosis mediates the cellular uptake of micronutrients and cell surface proteins. Clathrin-mediated endocytosis (CME) is the housekeeping pathway in resting cells but additional Clathrin-independent endocytic (CIE) routes, including Fas...
Cytoskeleton regulators CAPZA2 and INF2 associate with CFTR to control its plasma membrane levels under EPAC1 activation [0.03%]
CAPZA2和INF2通过EPAC1调节细胞质骨架并作用于CFTR以控制其膜水平表达量
João D Santos,Francisco R Pinto,João F Ferreira et al.
João D Santos et al.
Cystic Fibrosis (CF), the most common lethal autosomic recessive disorder among Caucasians, is caused by mutations in the gene encoding the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein, a cAMP-regulated chloride channe...