Structural basis for inhibition of SpyCas9 by the anti-CRISPR protein AcrIIA26 [0.03%]
AcrIIA26抑制SpyCas9的分子机制研究
Scott Bailey,Iris Zheng,Brian Learn
Scott Bailey
CRISPR-Cas9 systems provide adaptive immunity in prokaryotes by targeting and cleaving invading phage DNA. In response, phages have evolved anti-CRISPR (Acr) proteins to inhibit Cas9 and evade this immune response. AcrIIA26 is a type II-A a...
The Role of Linker Length and Composition in Actin Binding and Bundling by Palladin [0.03%]
全长帕尔达丁及截短的帕尔达丁在与肌动蛋白结合和聚集方面的作用：长度及组成成分的影响
Rachel A Sargent,Colby W Bradford,Lauren M Hughes et al.
Rachel A Sargent et al.
Interdomain linkers in multidomain proteins influence spatial arrangement, flexibility, and cooperative binding, yet their functional roles remain underexplored. Palladin, an actin scaffold protein essential for cytoskeletal organization, c...
Macrophage-specific N-terminal Truncation of Plin2 Limits the Size of Lipid Droplets [0.03%]
Plin2的N端截短特异发生在巨噬细胞中并限制了脂滴的大小
Yaru Tian,Xiaolong Huang,Yuanyuan Wei
Yaru Tian
Lipid droplets (LDs) are dynamic organelles that exhibit cell-type-specific heterogeneity in size, composition, and abundance to support diverse cellular functions. However, the molecular mechanisms regulating this functional diversity rema...
Identification and functional characterization of two CXCL17 paralogs from zebrafish [0.03%]
斑马鱼CXCL17同源蛋白的鉴定及功能初探
Jie Yu,Wen-Feng Hu,Juan-Juan Wang et al.
Jie Yu et al.
C-X-C motif chemokine ligand 17 (CXCL17) and its receptor G protein-coupled receptor 25 (GPR25) have been identified as a significant pair in regulating immunity, but CXCL17 orthologs have not yet been identified from non-mammalian vertebra...
Molecular foundations of collagen triple helical assembly: the central role of prolyl-4-hydroxylation [0.03%]
胶原蛋白三螺旋组装的分子基础：脯氨酸4-羟基化的作用机制
Ashutosh Joshi,Bhaskar Mondal,Trayambak Basak
Ashutosh Joshi
Collagen, the principal structural protein of the extracellular matrix, has been pivotal in the evolution of multicellular life. Among its posttranslational modifications (PTMs), prolyl-4-hydroxylation stands out as the most conserved and f...
De novo cyclic peptides allow visualisation of the monomeric and functional amyloid conformations of the kinase RIPK3 [0.03%]
从头设计的环状多肽可用于视觉化激酶RIPK3单体和功能淀粉样蛋白结构
Jessica A Buchanan,Olivia Lavidis,Nicholas Shields et al.
Jessica A Buchanan et al.
Receptor Interacting Protein Kinase 3 (RIPK3) is a central regulator of necroptosis and a key mediator of inflammatory signaling. Its function is orchestrated through RIP Homotypic Interaction Motif (RHIM)-dependent interactions with other ...
Crystal structure and nanobodies against domain 3 of the malaria parasite fusogen Plasmodium falciparum HAP2 [0.03%]
疟原虫融合蛋白HAP2的第3结构域的晶体结构和纳米抗体
Frankie M T Lyons,Jill Chmielewski,Li-Jin Chan et al.
Frankie M T Lyons et al.
Malaria parasites are transmitted to humans through a bite from an infected female Anopheles mosquito. Within the mosquito midgut, malaria parasite gametes are activated and undergo fertilisation. If parasite fertilisation is perturbed, thi...
Insights into PINK1/Parkin function and dysfunction from Drosophila models [0.03%]
来自果蝇模型的PINK1/Parkin功能及其异常的功能见解
Seoyoung Park,Nikita Kozhushko,Thomas H Wight et al.
Seoyoung Park et al.
Loss-of-function mutations in PINK1 and PRKN cause familial forms of Parkinson's disease (PD). In vitro studies have revealed incredible insights into the molecular and cell-biological function of these genes, which have focused predominant...
Targeting calcineurin: a synergistic strategy with caspofungin to induce farnesol-mediated quorum sensing in Nakaseomyces glabrata-an inoculum-dependent tale [0.03%]
靶向钙调磷酸酶：与卡斯帕fungin协同作用以诱导光滑假丝酵母中的法尼醇介导的群体感应-一个依赖接种量的故事
Yu-Ke Cen,Lu-Lu Zhang,Zi-Jie Zhang et al.
Yu-Ke Cen et al.
Using Nakaseomyces glabrata as a model organism, we demonstrate that targeting calcineurin can synergize with caspofungin to induce a quorum sensing (QS) effect mediated by farnesol. This QS effect requires calcineurin deficiency, sub-minim...
A mitochondrial amidoxime-reducing component 1 (mARC1) A168T amino acid substitution does not confer protection from MASH and fibrosis in multiple mouse models of chronic liver disease [0.03%]
线粒体氧化还原成分1（mARC1）A168T氨基酸替代物不会在慢性肝病小鼠模型中赋予对门脉高压和纤维化的保护作用
Sentibel Pandovski,Tiffany Yang,Heather Zhou et al.
Sentibel Pandovski et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a disorder characterized by anomalous hepatic fat accumulation and one of the leading causes of chronic liver disease. Recent genome-wide association studies identified a m...