Depurination of sarcin/ricin loop 25S rRNA is signaled through the small ribosomal subunit during translation [0.03%]
解旋的核糖体25S rRNA 的 胸苷通过翻译期间的小亚基进行信号传导
Tanya Prashar,Katalin A Hudak
Tanya Prashar
In addition to their function in protein synthesis, translating ribosomes serve as sensors that communicate the presence of aberrant messenger RNAs (mRNAs); however, how they recognize damage to their ribosomal RNA (rRNA) remains poorly und...
Interdomain assembly between the fungal tRNA ligase adenylyltransferase and kinase domain [0.03%]
真菌tRNA连接酶腺苷酰基转移酶和激酶结构域的跨域组装
Sandra Köhler,Jirka Peschek
Sandra Köhler
Trl1-type ligases play an essential role in fungi and plants during the non-conventional tRNA splicing as well as the unfolded protein response. The tripartite enzyme consists of an N-terminal adenylyltransferase domain (LIG), a central pol...
Integrated NMR and MD structure and dynamics of the stem loop II motif (s2m) from the Omicron variant of SARS-CoV-2 [0.03%]
结合NMR和MD的SARS-CoV-2奥密克戎变异株茎环II结构与动态学特征研究
Tobias Matzel,Joseph Makowski,Adam H Kensinger et al.
Tobias Matzel et al.
The stem-loop-II motif (s2m) is a conserved viral RNA element located in the 3'UTR of different viruses including SARS-CoV-2. High resolution 3D structural data for s2m are only available for the fundamentally different SCoV-1 version and d...
Desthiobiotin (DTB)-modified and TAMRA-modified 2''OMeNAD+ are RNA 2'-phosphotransferase (Tpt1) poisons that enable affinity-tagging and fluorescence-tagging of internal RNA 2'-phosphate groups [0.03%]
.desthiobiotin（DTB）和tamra修饰的2''ome nad+是rna 2'-磷酸转移酶（tpt1）抑制剂，可实现rna内部2'-磷酸基团的亲和标记和荧光标记
Renata Kasprzyk,Shreya Ghosh,Stewart Shuman
Renata Kasprzyk
RNA 2'-phosphotransferase Tpt1 catalyzes the removal of an internal RNA 2'-PO4 via a two-step mechanism in which: (i) the 2'-PO4 attacks NAD+ C1'' to form an RNA-2'-phospho-(ADP-ribose) intermediate and nicotinamide; and (ii) transesterific...
Specific targeting of transcriptional T-box riboswitches leads to effective inhibition of S. aureus [0.03%]
特定靶向转录T盒核糖开关可有效抑制金黄色葡萄球菌
Nikoleta Giarimoglou,Adamantia Kouvela,Athanasios Papakyriakou et al.
Nikoleta Giarimoglou et al.
T-box riboswitches belong to a specific class of RNA regulatory elements that control gene expression in Gram-positive bacteria, including prominent human pathogens. They sense the availability of amino acids by detecting the aminoacylation...
Polyadenylation landscape of in vivo long-term potentiation in the rat brain [0.03%]
大鼠脑内长期增强的多聚腺苷酸化景观
Natalia Gumińska,Francois P Pauzin,Bożena Kuźniewska et al.
Natalia Gumińska et al.
Local protein synthesis in neurons is vital for synaptic maintenance and plasticity, yet the regulatory mechanisms, particularly cytoplasmic polyadenylation, are not fully understood. This study employed nanopore sequencing to examine trans...
Cassandra N Smoak,Estelle N Gardner,Renee N Chua et al.
Cassandra N Smoak et al.
Adenosine deaminase acting on RNA 1 (ADAR1) edits double-stranded RNA (dsRNA) substrates by the deamination of adenosine to inosine in a process known as A-to-I editing. Modulation of ADAR1 expression and editing activity has previously bee...
The codon context provides cis-acting immune evasion for the human papilloma virus (HPV) E6 [0.03%]
密码子背景能为人类乳头瘤病毒(E6)提供顺式作用的免疫逃避机制
Aikaterini Thermou,Chrysoula Daskalogianni,Lixiao Wang et al.
Aikaterini Thermou et al.
Human papilloma viruses (HPV) are linked to cancers but how virus-carrying tumor cells express HPV-encoded antigens without attracting the immune system is still poorly understood. Here we show how low- and high-risk HPV types equally explo...
Corrigendum: Copy number determination of sperm-borne small RNAs implied in the intergenerational inheritance of metabolic syndromes [0.03%]
更正：精子携带的小RNA拷贝数与代谢综合征的跨代遗传有关
Lisa König,Victoria Guggenberger,Kristeli Eleftheriou et al.
Lisa König et al.
Published Erratum
RNA (New York, N.Y.). 2025 Sep 16;31(10):1536. DOI:10.1261/rna.080709.125 2025
Development of a modified RNA circularization system to improve circRNA-based protein expression in mammalian cells [0.03%]
开发一种改进的RNA环化系统以提高哺乳动物细胞中circRNA介导的蛋白质表达
Mingting Cui,Shunran Li,Yuhang Han et al.
Mingting Cui et al.
Circular RNA (circRNA) is emerging as a highly promising technology in various biomedical applications, offering advantages over traditional linear RNA. The Tornado (Twister-optimized RNA for durable overexpression) system has been widely i...