Editing-independent effects of Drosophila Adar on heterochromatin silencing [0.03%]
Drosophila Adar对异染色质沉默的非编辑依赖性效应
Khadija Hajji,Damiano Amoruso,Barbora Novakova et al.
Khadija Hajji et al.
ADAR RNA editing enzymes deaminate selected adenosines to inosines in dsRNA. In Drosophila, inosine in dsRNA inhibits cleavage by Dcr2 and some ADAR proteins contribute an additional, editing-independent inhibition. The Drosophila AdarG iso...
Oliver Muhlemann,Evangelos D Karousis
Oliver Muhlemann
Three new studies (Arpa et al. 2026; Kurscheidt et al. 2026; Modena et al. 2026) found that the PIN domains of SMG5 and SMG6, two proteins involved in nonsense-mediated mRNA decay (NMD), interact and show that the physiological endonucleoly...
Degradation factor 1, Def1, regulates mRNA translation and decay through Ccr4-Not-dependent ubiquitylation of the ribosome [0.03%]
降解因子1通过Ccr4-Not依赖性的核糖体泛素化调节mRNA的翻译和衰减
Oluwasegun T Akinniyi,Aswathy Sebastian,Shardul Kulkarni et al.
Oluwasegun T Akinniyi et al.
Yeast Def1 is well known for its role in regulating RNA polymerase II elongation and degrading the large subunit of polymerase during transcriptional stress. It is an abundant cytoplasmic protein that undergoes stress-induced processing and...
Canonical microRNA loss drives tumor development implicating therapeutic efficacy of enoxacin in angiosarcoma [0.03%]
经典微小核糖核酸损失驱动肿瘤发生提示安杰奥萨瘤的盐酸环丙沙星治疗效应
Bozhi Liu,Ant Murphy,Annaleigh Benton et al.
Bozhi Liu et al.
Angiosarcoma (AS) is a rare and aggressive tumor arising within the endothelium, characterized by a high metastatic rate and poor prognosis. Our prior work established that endothelial loss of Dicer1, a key enzyme in microRNA (miRNA) proces...
Stalled translation on transcripts cleaved by RNase L activates signaling important for innate immunity [0.03%]
stalled翻译产物激活对先天免疫重要的信号通路
Agnes Karasik,Grant D Jones,Nicholas R Guydosh
Agnes Karasik
RNase L is an endonuclease that responds to infections by cleaving most host- and pathogen-derived single-stranded RNAs. This widespread RNA cleavage can lead to death of the infected cell via the ribotoxic stress response (RSR). An ongoing...
Genetic and genomic approaches to explore roles for the conserved 3'-5' exoribonuclease EXOSC10 in normal and malignant cells [0.03%]
探讨保守的3'-5'外核糖核酸酶EXOSC10在正常和恶性细胞中的作用的基因组和基因组方法
Radhika Sain,Julian Primig,Michael Primig
Radhika Sain
EXOSC10 is a conserved 3'-5' exoribonuclease involved in processing ribosomal RNAs and degrading coding and non-coding transcripts as a catalytic subunit of the nuclear RNA exosome and in cooperation with co-factors. The protein is post-tra...
Terminal Loop Sequences in Viral Double-Stranded RNAs Modulate RIG-I Signaling [0.03%]
病毒双链RNA中的末端回文序列调控RIG-I信号通路
Matthew Hackbart,Patrick Wang,Victoria Gnazzo et al.
Matthew Hackbart et al.
Detection of foreign RNAs is a crucial activation step for innate immunity pathways in response to viral infections. Retinoic acid-inducible gene I (RIG-I) is a cytoplasmic RNA sensor that triggers type I and III interferon (IFN) expression...
A novel NLP-based method and algorithm to discover RNA-binding protein (RBP) motifs, contexts, binding preferences, and interactions [0.03%]
一种基于NLP的新方法和算法，用于发现RNA结合蛋白（RBP）的基序、上下文、结合偏好和相互作用
Shaimae I Elhajjajy,Zhiping Weng
Shaimae I Elhajjajy
RNA-binding proteins (RBPs) are essential modulators in the regulation of mRNA processing. The binding patterns, interactions, and functions of most RBPs are not well-characterized. Previous studies have shown that motif context is an impor...
Ancestral intronic splicing regulatory elements in the SCNα gene family [0.03%]
SCNα基因家族中的祖先内含子剪接调控元件
Ekaterina Chernyavskaya,Margarita Vorobeva,Sergei A Spirin et al.
Ekaterina Chernyavskaya et al.
SCNα genes encode components of voltage-gated sodium channels that are crucial for generating electrical signals. Humans have ten paralogous SCNα genes, some of which contain duplicated mutually exclusive exons 5a and 5b. In reconstructin...
Jordan L Meier
Jordan L Meier
This Perspective discusses seven frontiers in RNA modification research. The examples cited highlight technological advances, regulatory principles both unique and broad-spanning, and questions about how biological information is post-trans...