PANTHER - Protein-Affinity for Nucleic Target-binding, Hybridization, and Energy Regression [0.03%]
基于亲和力的核酸结合位点预测方法PANTHER
Parisa Aletayeb,Akash Deep Biswas,Stefano Rocca et al.
Parisa Aletayeb et al.
Although protein-RNA interactions are crucial for many biological processes, predicting their binding free energies (ΔG) is a challenging task due to limited available experimental data and the complexity of these interactions. To address ...
Fission yeast Tpt1 is composed of tandem RNA 2'-phosphotransferase and Yae1 domains, both of which are essential for viability [0.03%]
芽殖酵母Tpt1由串联的RNA 2'-磷酸转移酶结构域和Yae1结构域组成，两者对于其细胞活力都至关重要
Apurba Sarkar,Beate Schwer,Stewart Shuman
Apurba Sarkar
RNA 2'-phosphotransferase Tpt1 is a widely distributed enzyme that removes an internal RNA 2'-phosphate by transfer to NAD+. Tpt1 is essential in fungi, where it erases the 2'-PO4 mark installed by tRNA ligase during tRNA splicing. Tpt1 exe...
5' UTR Cis-Regulatory Logic Governs Ribosome Engagement on Canonical and Non-Coding RNAs [0.03%]
5'UTR顺式调控逻辑调控经典和非编码RNA的核糖体结合
Siang Chen,Dongdong Zhang,Hao Wang et al.
Siang Chen et al.
Eukaryotic translation initiation is critically regulated by 5' UTR features, including uORFs, Kozak sequences, and secondary structures, that modulate ribosome dynamics. Although canonical mRNAs dominate protein synthesis, ribosome profili...
MUTACLASH: Identifying functional small RNA target sites using crosslinking-induced mutations [0.03%]
基于交联诱导突变鉴定功能小RNA靶位点
Wei-Sheng Wu,Dong-En Lee,Chi-Jung Chung et al.
Wei-Sheng Wu et al.
Small RNAs play essential roles in gene regulation across diverse biological processes. Crosslinking, ligation, and sequencing of hybrids (CLASH) experiments have revealed that PIWI and Argonaute proteins can each bind a wide range of mRNA ...
Comprehensive mapping of the 5' and 3' untranslated regions of Aspergillus fumigatus reveals diverse mechanisms of mRNA processing including premature transcription termination [0.03%]
黏质沙雷氏菌全面映射粘质沙雷菌的5'和3'非翻译区揭示了包括转录提前终止在内的信使rna处理的多样机制
Lukas Schrettenbrunner,Corinne Maufrais,Guilhem Janbon et al.
Lukas Schrettenbrunner et al.
In the twenty years since the first genome sequencing of Aspergillus fumigatus, the field has seen an explosion in both the number of sequenced genomes and our molecular understanding of this ubiquitous human fungal pathogen. Despite an imp...
Loop of Fate: Structural and Mechanistic Insights into hnRNPA1 Binding to the Hepatitis C Virus RNA [0.03%]
命运的循环：HCV RNA与hnRNPA1相互作用的结构和机理分析
Ajit Kumar,Srinivas Penumutchu,Love Panchariya et al.
Ajit Kumar et al.
Hepatitis C virus (HCV) is a major global health burden, associated with chronic liver diseases including cirrhosis and hepatocellular carcinoma. Viral replication critically depends on conserved cis-acting RNA elements (CREs), such as the ...
A Mycobacterium tuberculosis Mbox controls a conserved, small upstream ORF via a translational expression platform and rho-dependent termination of transcription [0.03%]
一个结核分枝杆菌Mbox通过一种转录终止的转录表达平台控制保守的小上游ORF
Alexandre D&#x;Halluin,Terry Kipkorir,Catherine Hubert et al.
Alexandre D&#x;Halluin et al.
Magnesium is vital for bacterial survival, and its homeostasis is tightly regulated. Intracellular pathogens like Mycobacterium tuberculosis (Mtb) often face host-mediated magnesium limitation, which can be counteracted by upregulating the ...
Novel Trinucleotide mRNA Capping Reagents: Improved Synthetic Route and Efficient Co-transcriptional Incorporation in mRNA [0.03%]
新型三核苷酸mRNA加帽试剂：改进的合成路线和有效的同步转录引入
Chunping Xu,Russell Cousins,Ilya Ilichev et al.
Chunping Xu et al.
The 5'-N7-methylated guanosine triphosphate cap structure plays a critical role in mRNA translation and mRNA stability. The recent invention of co-transcriptional capping of mRNAs using Trinucleotide Capped Primers (TCP) allowed for develop...
Corrigendum: Pharmacologically stabilizing RNA G-quadruplexes in coronavirus genome reduces infectivity [0.03%]
更正：药理稳定冠状病毒基因组中的RNA G-四链体可降低其感染性
Yong Woo Lee,Roy Blum,Tyler Mrozowich et al.
Yong Woo Lee et al.
Published Erratum
RNA (New York, N.Y.). 2025 Nov 17;31(12):1927. DOI:10.1261/rna.080821.125 2025
Miniature NAD+-II riboswitches control bacterial genes for nicotinamide salvage and de novo NAD+ biosynthesis [0.03%]
微小的NAD + -II核糖开关控制细菌基因进行烟酸补救和从头NAD + 生物合成
Christopher G King,Kenny P Cheng,Ronald R Breaker
Christopher G King
Nicotinamide adenine dinucleotide (NAD) is a ubiquitous enzyme cofactor that serves as a carrier of hydride ions for metabolic oxidation-reduction reactions. NAD is also sometimes used as a source of activated adenosine monophosphate (AMP) ...