Understanding off-target growth defects introduced to influenza A virus by synonymous recoding [0.03%]
同义词重组引入的流感病毒脱靶增殖缺陷的理解
Colin P Sharp,Beth H Thompson,Ananya Ferdous Hoque et al.
Colin P Sharp et al.
CpG dinucleotides are under-represented in the genomes of most RNA viruses. Synonymously increasing CpG content of a range of RNA virus genomes reliably causes replication defects due to the recognition of CpG motifs in RNA by cellular Zinc...
C. elegans FBF-1 and FBF-2 C-terminal intrinsically-disordered regions differentially regulate RNA-binding affinity [0.03%]
FBF-1和FBF-2的C端无序区以不同方式调节其RNA结合活性
Hope R Hawthorne,Chen Qiu,Traci M Tanaka Hall
Hope R Hawthorne
PUF proteins (named for Drosophila melanogaster Pumilio and Caenorhabditis elegans fem-3 mRNA binding factor or FBF) are a family of RNA-binding proteins. C. elegans FBF is a collective term for two PUF proteins, FBF-1 and FBF-2, that maint...
Junjie Li,Chu Xu,Xiao Jiang et al.
Junjie Li et al.
Membrane-less organelles, dynamic subcellular structures formed by RNA and RNA-binding proteins (RBPs) undergoing liquid-liquid phase separation (LLPS), play key roles in biological processes such as RNA degradation in processing bodies (P-...
Accurate in silico predictions of modified RNA interactions to a prototypical RNA-binding protein with λ-dynamics [0.03%]
利用λ动力学精确预测修饰RNA与典型RNA结合蛋白的相互作用
Murphy Angelo,Yash Bhargava,Elzbieta Kierzek et al.
Murphy Angelo et al.
RNA-binding proteins shape biology through their widespread functions in RNA biochemistry. Their function requires the recognition of specific RNA motifs for targeted binding. These RNA binding elements can be composed of both unmodified an...
40S ribosomal subunits scan mRNA for the start codon by one-dimensional diffusion [0.03%]
40S核糖体亚基以一维扩散方式扫描mRNA起始密码子
Hironao Wakabayashi,Mingyi Zhu,Elizabeth J Grayhack et al.
Hironao Wakabayashi et al.
During eukaryotic translation initiation, the small (40S) ribosomal subunit is recruited to the 5' cap and subsequently scans the 5' untranslated region (5' UTR) of mRNA in search of the start codon. The molecular mechanism of mRNA scanning...
Two-step target recognition for the competitive inhibition activity of an anti-VEGF aptamer [0.03%]
用于抗VEGF适配子竞争性抑制活性的两步靶标识别方法
Koh Takeuchi,Takumi Ueda,Misaki Imai et al.
Koh Takeuchi et al.
The anti-vascular endothelial growth factor (VEGF) aptamer, t44.27, is a 27-mer RNA that functions as the active component of pegaptanib, an anti-angiogenic medicine for neovascular age-related macular degeneration. The t44.27 aptamer is ex...
Bacterial/archaeal protein-only RNase P: complementation in Escherichia coli uncovers coevolution of protein-only RNase P and precursor tRNA structures in Aquifex aeolicus [0.03%]
细菌/古菌蛋白质RNase P：在大肠杆菌中的互补揭示了Aquifex aeolicus中蛋白质RNase P和前体tRNA结构的协同进化
Swetlana Davydov,Nadine B Waeber,Markus Goessringer et al.
Swetlana Davydov et al.
The family of RNase P endoribonucleases comprises diverse enzyme architectures ranging from complex ribonucleoprotein assemblies to single polypeptides as small as ~23 kDa termed Homologs of Aquifex RNase P (HARPs). The HARPs of two hyperth...
Solution Structure Determination and Biophysical Studies of 7SK RNP and 7SL SRP RNAs [0.03%]
7SK RNP和7SL SRP RNA的溶液结构测定与生物物理研究
Michael H D&#x;Souza,Higor Sette Pereira,Scott Tersteeg et al.
Michael H D&#x;Souza et al.
Small noncoding RNAs perform integral roles in eukaryotic lifecycles, particularly the 7SK snRNA, which is responsible for RNA Polymerase II transcription modulation and progression when interacting with P-TEFb, and the 7SL RNA involved in ...
Stress granules promote quiescence by enhancing p21 levels and reducing phospho-Rb [0.03%]
压力颗粒通过提高p21水平和降低磷酸化Rb来促进静止期
Anthony Khong,Nina Ripin,Luisa Macedo de Vasconcelos et al.
Anthony Khong et al.
During the integrated stress response (ISR), most mRNAs exit translation and some condense into stress granules. Stress granules that form during chemotherapy can promote cancer cell survival and chemoresistance by an unknown mechanism. Cel...
Promiscuous RNA editing in lncRNA roX1 is generally non-adaptive [0.03%]
lncRNA roX1中放纵的RNA编辑通常是非适应性的
Jiyao Liu,Qiuhua Xie,Wanzhi Cai et al.
Jiyao Liu et al.
Adaptation of adenosine-to-inosine (A-to-I) RNA editing has only been validated for a few nonsynonymous (recoding) sites, where the editable state confers higher fitness than the uneditable or fully-edited state. However, adaptation of non-...