Grzegorz Szwachta,Ewelina Jalonicka,Tomasz Rygiel et al.
Grzegorz Szwachta et al.
Lasing spectroscopy (LS) is emerging as a powerful extension of conventional fluorescence methods for highly sensitive bioanalytical detection. By exploiting stimulated emission and optical feedback mechanisms, LS generates narrow spectral ...
Elementary processes and mechanisms of nanopore formation induced by antimicrobial peptides and other membrane-active peptides [0.03%]
抗菌肽和其他活性膜肽诱导纳米孔形成的初级过程和机制
Md Masum Billah,Yukihiro Tamba,Md Zahidul Islam et al.
Md Masum Billah et al.
The activity of membrane-active peptides/proteins (MAPs) involves interactions with lipid bilayer regions of cell membranes. For example, antimicrobial peptides, lytic peptides, pore-forming toxins, lipidated peptides, and cell-penetrating ...
Biomineralization: Perspectives on control of crystal polymorphism, order-disorder and solvation states [0.03%]
生物矿化：控制晶体多形性、有序-无序以及溶剂化态的视角
Lia Addadi,Steve Weiner
Lia Addadi
Some of the most challenging issues in biomineralization relate to understanding how organisms control the properties of the minerals and molecular crystals that they form. Here, we examine these largely unresolved issues by considering fac...
The pivotal roles of cellular biophysics and mechanobiology in the development of Human Organs-on-Chips [0.03%]
细胞生物物理和机械生物学在人体器官芯片开发中的关键作用
Donald E Ingber
Donald E Ingber
The development of Human Organs-on-Chips (Organ Chips) - microfluidic culture devices lined by living human tissues that recapitulate organ-level pathophysiology and offer a new approach to replace animal testing in drug development and adv...
Biophysics meets fungal biology: Characterising the fungal cell envelope and its interactions with drug-like molecules [0.03%]
生物物理学与真菌生物学的结合：表征真菌细胞包膜及其与药物分子的相互作用
Obed Obeng-Gyasi,Evelyne Deplazes
Obed Obeng-Gyasi
The fungal cell envelope, consisting of the cell wall and plasma membrane, is a dynamic structure crucial for cell shape, viability, pathogenicity, and the cell's ability to interact with and respond to its environment. Most antifungal drug...
Energy landscapes in molecular biology: History, principles, and perspectives [0.03%]
分子生物学中的能量景观：历史、原理与展望
Ruth Nussinov,Clil Regev,Hyunbum Jang
Ruth Nussinov
In an editorial for a Special Issue, Nussinov and Wolynes explored the energy landscapes of biomolecular function, questioning whether they constituted a second molecular biology revolution. With more than a decade having passed and science...
The influence of structure, dissociation constants, and an aqueous environment on the physicochemical properties of L-α-amino acids [0.03%]
结构、离解常数及水介质对L-氨基酸理化性质的影响
Marek Pająk,Magdalena Woźniczka,Elżbieta Kamysz et al.
Marek Pająk et al.
L-α-amino acids are the fundamental building blocks of proteins and play a pivotal role in the biochemistry of living organisms. The behavior of these molecules in an aqueous solution – the primary medium for biological reactions – is co...
Crystallographic binding modes of octahedral transition metal complexes to duplex DNA [0.03%]
八面体过渡金属配合物与双链DNA结合的晶体结构及结合模式
Tayler D Prieto Otoya,Christine Janet Cardin
Tayler D Prieto Otoya
Octahedral transition metal complexes are increasingly recognised as useful tools for the development of complex cations that recognise and interact with specific DNA sequences and higher-order DNA topologies. The versatility and diversity ...
Cryo-EM of endogenous membrane proteins in their native lipid bilayer [0.03%]
在天然脂质双层中对内源性膜蛋白进行冷冻电镜分析
John L Rubinstein
John L Rubinstein
Single-particle electron cryomicroscopy (cryo-EM) has enabled rapid advances in our understanding of membrane protein structure and function. The primary goal during the development of cryo-EM was to perform experiments equivalent to X-ray ...
Julien Roche,Christian Roumestand,Catherine A Royer
Julien Roche
While the structure of proteins can now be predicted from sequence with high certainty, the prediction of protein functional dynamics remains to be achieved. Progress towards this goal will require a much larger experimental database of the...