Proteostasis at the mitochondrial outer membrane: Quality control of mitochondrial protein transport [0.03%]
Shunsuke Matsumoto,Suzuka Ono,Toshiya Endo
Shunsuke Matsumoto
Mitochondria are enclosed by a double-membrane structure composed of the outer and inner membranes, and this architectural organization underlies their diverse cellular functions. In particular, the mitochondrial outer membrane serves as an...
Conkazal-M1 from the MKAVA family of conotoxins: A dual-function protease inhibitor and neuroactive peptide [0.03%]
Celeste M Hackney,Thomas Lund Koch,Nicklas Lund Ryding et al.
Celeste M Hackney et al.
Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and ...
Abraham Muñiz-Chicharro,Lane W Votapka,Rommie E Amaro
Abraham Muñiz-Chicharro
We present burbuja (Baring Unseen Regions of Bubbles Using Joint-Density Analysis), an automated software tool for detecting and characterizing gas bubbles and other local voids in molecular structures and trajectories containing explicit a...
Souleïmen Jmii,William Bouard,Mathilde Rochas et al.
Souleïmen Jmii et al.
The SCFSLY1 ubiquitin ligase complex is a key regulator of gibberellin signaling, mediating the degradation of DELLA proteins through targeted ubiquitination. To enable detailed biochemical and structural studies of this complex, efficient ...
Single-molecule force spectroscopy discovers a dual-binding mode in the hCG-mediated activation of LHCGR [0.03%]
Qian Han,Yilong He,Ziyang Yao et al.
Qian Han et al.
Human Chorionic Gonadotropin (hCG) mediates the activation of luteinizing hormone/choriogonadotropin receptor (LHCGR) by binding to it, which is critical for human reproduction. However, specific dynamics of such interaction remain ambiguou...
Priyanka Bose,Irit Dahan,Alexander Upcher et al.
Priyanka Bose et al.
Enzymes that assemble into filaments typically transition between protomeric and polymeric states in response to cellular conditions. In contrast, the secreted acid phosphatase (SAP) of Leishmania, one of the most abundant extracellular gly...
Lara Kroczek,Thomas Langer
Lara Kroczek
Mitochondria are essential organelles that drive numerous cellular processes, including energy metabolism, ion homeostasis, and programmed cell death. This functional versatility relies on a highly dynamic proteome whose composition is cont...
T3SS effector and regulator discovery by predicting interacting partners of T3SS chaperones in Pseudomonas aeruginosa [0.03%]
Jing Zhang
Jing Zhang
Pseudomonas aeruginosa is a prominent opportunistic pathogen whose virulence is closely linked to its Type III Secretion System (T3SS), a specialized apparatus that injects effector proteins into host cells. T3SS chaperones are essential fo...
copick: An open dataset interface and toolkit for collaborative annotation and analysis of cryo-electron tomography data [0.03%]
Utz Heinrich Ermel,Jonathan Schwartz,Zhuowen Zhao et al.
Utz Heinrich Ermel et al.
Cryo-electron tomography (cryoET) enables visualization of macromolecular complexes within intact cellular environments. Continued improvements in instrumentation, sample preparation, and data-processing pipelines have increased both the sc...
Structural and functional insights into TBC1D17 highlight the importance of the previously uncharacterized Rab-binding domain [0.03%]
Dominika Nielipińska,Marta Orlikowska,Maciej Nielipiński et al.
Dominika Nielipińska et al.
TBC (Tre2/Bub2/Cdc16) domain-containing proteins constitute the widespread family of GTPase-activating proteins (GAPs). They interact with the Rab superfamily of small GTPases, stimulate GTP hydrolysis, and regulate vesicle trafficking. TBC...