Age- and sex-specific modulation of human cardiac electrophysiology by doxorubicin [0.03%]
多柔比星对人类心脏电生理的年龄和性别特异性调节作用
Sharon A George,Amber V Mills,Erin O&#x;Neill et al.
Sharon A George et al.
Acute doxorubicin (DOX)-induced cardiotoxicity leads to electrophysiological changes, including QT prolongation, reduced QRS voltages and T-wave abnormalities. We previously demonstrated in mice that the effects of DOX on cardiac electrophy...
In the gravid human uterus, oxytocin induces smooth muscle cell contraction via transient receptor potential vanilloid 4 channel activation [0.03%]
催产素通过瞬时受体电位香草酸受体4通道激活诱导人类妊娠子宫平滑肌收缩
Daiana Fornes,Jessica R Ansari,Guillermina Michel et al.
Daiana Fornes et al.
Understanding the mechanism of oxytocin-induced uterine contractility is critical for addressing conditions at both extremes of the uterine contractility spectrum, preterm labour and uterine atony. We hypothesized that oxytocin induces extr...
Low-dose lithium, oestrogen deficiency and the sarcoplasmic reticulum: Are they connected? [0.03%]
低剂量锂、雌激素缺乏和肌浆网：它们有关联吗？
Joachim Nielsen
Joachim Nielsen
Post-exercise ketone supplementation improves endurance performance and mitochondrial adaptations during an 8-week endurance training intervention [0.03%]
运动后补充酮体可改善8周耐力训练中的耐力表现和线粒体适应性
Ruben Robberechts,Youri Bekhuis,Myrthe Stalmans et al.
Ruben Robberechts et al.
Post-exercise ketone supplementation (PEKS) previously improved endurance performance and muscular adaptations during overload training. However, whether and how PEKS improves endurance performance during a periodised endurance training per...
Profound neuronal differences during exercise-induced hypoalgesia between athletes and non-athletes revealed by functional near-infrared spectroscopy [0.03%]
功能性近红外光谱技术用于研究运动员和非运动员锻炼诱导镇痛的神经机制差异
Maria Geisler,Marco Herbsleb,Feliberto de la Cruz et al.
Maria Geisler et al.
Regular physical activity is an important treatment component for chronic pain. To unravel the neuronal influence of exercise on pain, we investigated the neuronal changes during exercise-induced hypoalgesia in endurance athletes and contro...
Zeynep Elif Yesilyurt-Dirican,Ce Qi,Uchenna Okpechi et al.
Zeynep Elif Yesilyurt-Dirican et al.
Mammalian ageing is defined as a gradual loss of the capacity to maintain tissue homeostasis or to repair tissues after injury or stress. Cellular senescence is induced by various cellular stressors, and there is accumulation of senescent c...
A primary cell-based fluidic co-culture model to investigate drug transport across the human placenta [0.03%]
一种基于原代细胞的流体共培养模型 用于研究药物通过人体胎盘的转运
Barbara Fuenzalida,Nadja Koechli,Edgar Ontsouka et al.
Barbara Fuenzalida et al.
Although women often need to take medication during pregnancy, reliable human-based models mimicking the maternal-fetal interface and allowing predictions on drug transport across the human placenta are scarce. In this study, we developed a...
Chai-Ann Ng
Chai-Ann Ng
Emily Shorter,Oscar Horwath,Sabrina Tzivia Barsky et al.
Emily Shorter et al.
Planned and progressive exercise, that is, exercise training, is essential for promoting skeletal muscle adaptation and improvements in athletic performance. However when the training demands exceed the ability to recover, it may lead to a ...
A computational model for retinal haemodynamics under gravitational and postural variations [0.03%]
考虑重力和体位变化的视网膜血液循环计算模型
Michele Nigro,Andrea Montanino,Eduardo Soudah
Michele Nigro
Spaceflight-associated neuro-ocular syndrome presents a significant risk during long-duration spaceflight, yet the retinal mechanisms underlying these visual changes remain poorly characterized. We developed a physiologically detailed lumpe...