Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting GluN2B subunits: implications for synaptic plasticity [0.03%]
乳酸通过一种新的半胱氨酸规则的红氧化还原机制增强N-甲基-D天冬氨酸受体电流：对突触可塑性的意义
Hubert Fiumelli,Gabriel Herrera-López,Fouad Lemtiri-Chlieh et al.
Hubert Fiumelli et al.
Astrocyte-derived lactate, through the astrocyte-neuron lactate shuttle, fuels neuronal energy demands and acts as a signalling molecule promoting synaptic plasticity and memory consolidation. Lactate regulates neuronal excitability and exp...
Reply from J. E. Mallinson, D. Constantin-Teodosiu, D. Constantin, M. V. Franchi and P. L. Greenhaff: NSAIDs and muscle hypertrophy - preconceptions and differing interpretations in the face of a paucity of data from long-term healthy volunteer studies [0.03%]
J. E. Mallinson，D. Constantin-Teodosiu，D. Constantin，M. V. Franchi和P. L. Greenhaff的回应：NSAIDs与肌肉肥大——在长期健康志愿者研究数据不足的情况下存在先入为主的观点和不同的解读
Joanne E Mallinson,Dumitru Constantin-Teodosiu,Despina Constantin et al.
Joanne E Mallinson et al.
Hypoxaemia and hypercapnia: Two gases, convergent outcomes, distinct pathways [0.03%]
缺氧与二氧化碳潴留：两种不同的致病因素导致相同的疾病结局
Michele Samaja,Giacomo Strapazzon
Michele Samaja
Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease [0.03%]
动物模型的启示：分解氧气和营养物在胎儿心血管疾病起源中的独立作用
Melanie R Bertossa,Jack R T Darby,Ashley S Meakin et al.
Melanie R Bertossa et al.
Depending on the pregnancy complication, substrate delivery to a developing fetus can be reduced, changing the course of fetal growth below the genetically determined in utero growth potential, resulting in fetal growth restriction (FGR). F...
Clarifying power-mediated aerosol effects and enhancing statistical rigor in in utero E-cigarette exposure research [0.03%]
澄清介电介质的气溶胶效应并增强统计严谨性以完善子宫内电子烟暴露研究
I Mark Olfert,Amber Mills,Caroline P Groth et al.
I Mark Olfert et al.
Electromechanical modelling and simulation of human-induced pluripotent stem cell-derived cardiomyocytes predict drug-induced contractility effects [0.03%]
基于人类诱导多能干细胞来源的心肌细胞的机电模型和模拟预测药物诱发的心肌收缩力效应
Milda Folkmanaite,Xin Zhou,Andreas Koschinski et al.
Milda Folkmanaite et al.
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold promise in personalized medicine, particularly for cardiac diseases and human-data-based pharmacology studies. Assessing hiPSC-CM mechanics and their changes in res...
Robust activity-dependent mitochondrial calcium dynamics at the AIS is dispensable for action potential generation [0.03%]
活动依赖的轴突初始段线粒体钙动力学对动作电位生成可有可无
Koen Kole,Maarten H P Kole
Koen Kole
Mitochondria are diverse and multifaceted intracellular organelles regulating oxidative energy supply, lipid metabolism and calcium (Ca2+) signalling. In neurons the spatial sequestration of cytoplasmic Ca2+ by mitochondria plays a critical...
Characterization of postnatal brain injury and behavioural deficits in a rat model of placental insufficiency-induced fetal growth restriction [0.03%]
胎盘功能不全所致胎儿生长受限大鼠模型中的产后脑损伤和行为缺陷的特征分析
Judit Alhama-Riba,Caroline G M de Theije,Valentina Salvi et al.
Judit Alhama-Riba et al.
Fetal growth restriction (FGR) is a significant pregnancy complication strongly associated with neurodevelopmental deficits in infants. Effective treatments to support brain development are currently lacking. Detailed characterization of st...
Can lithium fill the gap to mitigate metabolic and functional deficits following the loss of ovarian hormones? [0.03%]
锂能填补因失去卵巢激素而导致的代谢和功能缺陷的缺口吗？
Angela S Bruzina,William T Juckett
Angela S Bruzina
Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male mice [0.03%]
雄性小鼠海马淀粉样蛋白沉积诱导的持续性空间记忆损伤与后顶叶皮层振荡活动异常有关
Souhail Djebari,Ana Contreras,Victor Castro-Andrés et al.
Souhail Djebari et al.
In early stages of Alzheimer's disease (AD), soluble amyloid-β (Aβ) is a key player disrupting neuronal activity and contributing to cognitive decline in advanced stages of the disease. Although the hippocampus has been a central focus in...