Chronic hypoxia during gestation impairs Rad-mediated inhibition of CaV1.2 channel and increases uterine vascular resistance in pregnant sheep [0.03%]
妊娠期慢性缺氧损害Rad介导的CaV1.2通道抑制并增加怀孕绵羊子宫血管阻力
Xiang-Qun Hu,Rui Song,Chiranjib Dasgupta et al.
Xiang-Qun Hu et al.
Our recent study demonstrated that upregulation of Rad, a monomeric G protein, is a novel regulatory mechanism inhibiting CaV1.2 channel currents in uterine artery hemodynamic adaptation to pregnancy in a sheep model. In the present study, ...
A model of β-adrenergic stimulation in human ventricular cells for tissue-scale simulations of sympathetically modulated tachycardias [0.03%]
人室性细胞β肾上腺素刺激模型在交感神经调制心动过速组织规模仿真中的应用
Kelly Zhang,Karl Magtibay,Natalia Trayanova et al.
Kelly Zhang et al.
Ventricular tachycardia (VT) dynamics in myocardial infarction and heart failure patients could be influenced by heterogeneous sprouting of sympathetic nerves or alteration of β-adrenergic receptors to disrupt normal β-adrenergic receptor...
Distinctive neurophysiological correlates of sound onset and offset perception in humans [0.03%]
人类声音起始和终止感知的独特神经生理特征
Fatima Ali,Gabriela Bury,Adèle Simon et al.
Fatima Ali et al.
Accurate detection of sound onsets and offsets is thought to be vital for speech perception. Sound-onset event-related potentials (ERPs) have been well characterised in EEG studies, but the characteristics of sound-offset ERPs have often be...
Trophoblast-specific overexpression of Slc7a5 increases fetal amino acid availability and hepatic mTOR signalling and causes increased fetal growth [0.03%]
胎盘特异性Slc7a5过表达增加胎儿氨基酸有效利用和肝mTOR信号导致胎儿过度生长
Fredrick J Rosario,Hiroshi Shimada,Sam Blessen J Fredrick et al.
Fredrick J Rosario et al.
Abnormal fetal growth is linked to perinatal complications and increased risk of metabolic and cardiovascular diseases, yet the underlying mechanisms remain unclear. Placental System L amino acid transport is decreased in human pregnancies ...
Cardiac digital twins: Modelling the arrhythmic substrate of chemotherapy [0.03%]
化疗的心律失常基质的建模：心脏数字孪生体
Radomir Chabiniok,Vlad G Zaha
Radomir Chabiniok
Elevational variation in heart mass and suppression of hypoxia-induced right ventricle hypertrophy in Andean leaf-eared mice (Phyllotis) [0.03%]
安第斯网膜鼠心脏质量的海拔变化及其对低氧诱导的右心室肥厚的抑制作用
Naim M Bautista,Nathanael D Herrera,Marcial Quiroga-Carmona et al.
Naim M Bautista et al.
In lowland mammals that ascend to high elevation, hypoxia-induced changes in the pulmonary circulation can give rise to hypoxic pulmonary hypertension (HPH) and associated right-ventricle (RV) hypertrophy. Some mammals that are native to hi...
Two distinct mechanisms for GlyH-101 block of the CFTR chloride channel [0.03%]
GlyH-101特异性阻断CFTR氯通道的两种机制
Yu-Chen Chang,Zhiwei Ma,Shi-Ting He et al.
Yu-Chen Chang et al.
GlyH-101 is a commonly used pore blocker of the cystic fibrosis transmembrane conductance regulator (CFTR) to confirm the functional role of CFTR in model systems. Unlike most other anionic CFTR blockers GlyH-101 blocks CFTR from the extrac...
Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model [0.03%]
活性微区域与血管控制神经元和肌肉兴奋性：迈向统一模型
L Fernando Santana,Scott Earley
L Fernando Santana
Ion channels are often depicted as autonomous membrane switches, yet their function depends on upstream vascular and mitochondrial processes that deliver ATP to maintain the ionic gradients essential for cellular excitability. Here, we prop...
Selective RyR2 inhibition reduces arrhythmia susceptibility in human cardiac slices [0.03%]
选择性抑制 RyR2 可降低人类心脏切片的室颤易感性
Micah K Madrid,Katy A Trampel,Batool Salman et al.
Micah K Madrid et al.
Ryanodine receptor 2 (RyR2) hyperactivity is frequently observed in structural heart disease (SHD), commonly caused by ischemic heart disease. This aberrant Ca2+ release promotes irregular electrical activity and life-threatening arrhythmia...
Beyond the placenta: hepcidin as a hidden driver of fetal hypoxia in maternal obesity [0.03%]
胎盘之外：母亲肥胖通过他肽素隐秘地成为胎儿缺氧的原因
Larissa Brito Vieira de Melo
Larissa Brito Vieira de Melo