Elizabeth H Schneider,Kelly A Aromolaran,Michael C Sanguinetti et al.
Elizabeth H Schneider et al.
The human ether-à-go-go-related gene type 1 (hERG1) channel is a voltage-gated potassium channel encoded by the KCNH2 gene. hERG1 channels are essential to the repolarization of cardiac action potentials, and reduced function of the potass...
A high-fat, high-sucrose diet exacerbates muscle and metabolic pathology and undermines glucocorticoid efficacy in dystrophin-deficient mice [0.03%]
高脂肪、高蔗糖饮食可加剧 Duchenne 肌营养不良小鼠模型的肌肉和代谢病理，并影响皮质类固醇疗效
Morgan E Vorwald,Swathy Krishna,Ji Heun Lee et al.
Morgan E Vorwald et al.
Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease caused by dystrophin deficiency and characterized by progressive muscle wasting. DMD is frequently accompanied by obesity and insulin resistance (IR); however, their influen...
Miguel Martin-Aragon Baudel,Hannah Voorhees,Arsalan U Syed et al.
Miguel Martin-Aragon Baudel et al.
L-type CaV1.2 channels are key regulators of cellular function in diverse cell types, controlling processes that range from gene expression to muscle contraction. In arterial myocytes, CaV1.2 channels traffic to the plasma membrane and asse...
Glutamatergic modulation of transcranial direct current stimulation over the premotor cortex combined with peripheral nerve stimulation promotes observation-execution-related cortical excitability and motor performance [0.03%]
谷氨酸调节顶下小叶经颅直流电刺激联合周围神经刺激促进观察-执行相关的皮层兴奋性及运动表现提升
Fengxue Qi,Michael A Nitsche,Lijuan Wang et al.
Fengxue Qi et al.
Action observation and execution, transcranial direct current stimulation (tDCS) and peripheral nerve stimulation (PNS) enhance motor performance. This study aimed to investigate the effect of concurrent tDCS over the premotor cortex (PMC) ...
The ultrarapid delayed rectifier potassium current has important functional role in the repolarization reserve of canine and human ventricular muscle [0.03%]
超快延迟整流钾电流在犬和人心室肌去极化储备中的作用不容忽视
Alaa Amin E Abdelmagid,Aiman Saleh A Mohammed,Gábor Mohácsi et al.
Alaa Amin E Abdelmagid et al.
The ultrarapid delayed rectifier potassium current (IKur) has long been considered an atrial-specific current with no functional role in the ventricles, despite evidence of its expression in ventricular myocytes. In the present study we cha...
Tonotopically distinct OFF responses arise in the mouse auditory midbrain following sideband suppression [0.03%]
鼠脑中缝核听觉区通过边带抑制产生不同的OFF响应
Patrick D Parker,Amanda M Lauer,Dwight E Bergles
Patrick D Parker
The parsing of sensory information into discrete topographic domains is a fundamental principle of sensory processing. In the auditory cortex, these domains evolve during a stimulus, with the onset and offset of tones evoking distinct spati...
The multicellular environment of the re-entrant circuit in post-myocardial infarction ventricular tachycardia: Beyond fibrosis [0.03%]
心肌梗死后的室性心动过速的再入路通路多细胞环境：超越纤维化
Mohammed Obeidat,Jaffar Al-Sheikhli,Andrew M Blanks et al.
Mohammed Obeidat et al.
Ventricular tachycardia (VT) in the post-myocardial-infarction heart is sustained by re-entry arising from slow and heterogeneous impulse propagation within the infarct border zone. Seminal histological and electrophysiological studies demo...
Evidence that interglomerular inhibition generates non-monotonic concentration-response relationships in mitral/tufted glomeruli in the mouse olfactory bulb [0.03%]
小鼠嗅球前角细胞中回勾抑制产生非单调浓度-反应关系的证据
Lee Min Leong,David Wharton,Narayan Subramanian et al.
Lee Min Leong et al.
Animals can recognize an odour as the same odour across a range of concentrations and discriminate between odours in complex environments. Processing within the mouse olfactory bulb (OB) may be involved, yet the underlying mechanisms remain...
Longitudinal and cross-sectional evidence that daily resting and activity energy expenditures are independent in humans [0.03%]
纵向和横断面证据表明人体的每日静息能量消耗和活动能量消耗是独立的
Andrew K Yegian,Elizabeth Pachus,Leanne M Redman et al.
Andrew K Yegian et al.
Total energy expenditure (TEE) is commonly modelled as the sum of resting energy expenditure (REE), activity energy expenditure (AEE), and diet-induced thermogenesis (DIT). This additive model has recently been challenged by the constrained...