A simulation approach to integrated metabolic regulation in working skeletal muscle [0.03%]
用于工作骨骼肌代谢调节的仿真方法
Graham J Kemp
Graham J Kemp
Resistance training load does not explain interindividual variability in muscle hypertrophy: insights from recent evidence [0.03%]
抗阻训练负荷不能解释肌肥大的个体差异：来自近期研究的新视角
Pedro Gabriel Senger Braga,Júlio Benvenutti Bueno de Camargo,Bernardo Neme Ide
Pedro Gabriel Senger Braga
Elevated cardiac modulation of vagus nerve activity as a consequence of ischaemic cardiomyopathy [0.03%]
缺血性心肌病引起迷走神经活性的改变及其对心脏的影响
Donovan Bernard Smith
Donovan Bernard Smith
How breathing disrupts vision: hyperventilation-induced hypocapnia impairs oculomotor responses in resting humans [0.03%]
呼吸如何干扰视觉：过度换气引起的低碳酸血症会损害静息状态下人体的眼动反应
Yusei Yoshimura,Tomoka Sagawa,Seiji Ono et al.
Yusei Yoshimura et al.
Eye movements are precisely controlled by the brain to acquire clear and stable visual information, and eye movement measurements are also used as neurophysiological biomarkers. Hyperventilation, which reduces arterial carbon dioxide partia...
LRRC8A-containing anion channels promote glioblastoma proliferation via a WNK1/mTORC2-dependent mechanism [0.03%]
含有LRRC8A的阴离子通道通过WNK1/mTORC2依赖性机制促进胶质母细胞瘤增殖
Antonio M Fidaleo,Martin D Bach,Shaina Orbeta et al.
Antonio M Fidaleo et al.
Leucine-rich repeat-containing protein 8A (LRRC8A) is an essential subunit of the ubiquitously expressed volume-regulated anion channels (VRACs). Previous work has shown that LRRC8A is overexpressed in several cancers and is associated with...
Differential effects of sex and age on daily and infradian rhythms of mice [0.03%]
性别和年龄对小鼠昼夜节律和亚昼夜节律的不同影响
Pishan Chang,Timna Hitrec,Charlotte Muir et al.
Pishan Chang et al.
Intrinsic biological rhythms regulate key physiological and behavioural processes, yet the influence of sex and age on these rhythms is not fully understood. We comprehensively examined 24 h (circadian) and >24 h (infradian; 5 and 10 day) r...
Coordinated regulation of PIEZO2 by alternative splicing, post-translational modification, membrane trafficking and protein partners [0.03%]
PIEZO2的可变剪接、翻译后修饰、膜转运及互作蛋白的协调调节机制研究进展
Eunice I Oribamise,Qinglu Li,Mary G Garry
Eunice I Oribamise
PIEZO2 is a principal mechanotransduction channel for somatosensory and interoceptive signalling, yet coordinated regulation of this channel remains poorly understood. Emerging work reveals that multilayered regulation of PIEZO2 coordinates...
Role of Septin7 in mitochondrial dynamics and oxidative metabolism in C2C12 skeletal muscle cells [0.03%]
Septin7在C2C12骨骼肌细胞线粒体动力学和氧化代谢中的作用
Andrea Telek,Ivett Gabriella Szabó,Anikó Keller-Pintér et al.
Andrea Telek et al.
Mitochondria are dynamic organelles that undergo fusion and fission. Key proteins are needed to create mitochondrial networks, as well as facilitate biogenesis, fragmentation or movement within the cell. Septins are considered as the fourth...
Intracerebral age-independent reduction of endothelium-dependent hyperpolarization and nitric oxide signalling in the Dp16 mouse model of Down syndrome [0.03%]
唐氏综合征Dp16小鼠模型中内皮依赖性细胞超极化和一氧化氮信号传递的脑内年龄独立减少现象
Abigail N Russell,Danielle A Jeffrey,Gregory Seedorf et al.
Abigail N Russell et al.
Down syndrome (DS) is associated with a myriad of cardiovascular defects. Endothelial cells, which form the innermost layer of blood vessels, have been found to exhibit divergent morphology and functional impairments in the peripheral circu...