Sex-dependent responses to glucagon agonist therapies in obesity: Mechanistic insights and broader pharmacological implications [0.03%]
肥胖小鼠性别依赖的胰高血糖素激动剂治疗反应：机制及更广泛的药理学含义
Mathieu J Clavet,Isabella Trivieri
Mathieu J Clavet
Brain sparing in fetal growth restriction: The double-edged sword of fetal hypoxaemia [0.03%]
胎儿生长受限中的脑保护：胎儿缺氧的双刃剑现象
Beth J Allison,Tegan A White,Emily J Camm et al.
Beth J Allison et al.
Fetal hypoxaemia during pregnancy is not uncommon, arising from chronic placental insufficiency or acute stressors. In the case of placental insufficiency and chronic fetal hypoxia, fetal growth is reduced, resulting in fetal growth restric...
Protein kinase Cδ and pharmacomechanical coupling: Re-envisioning cerebral vascular control [0.03%]
蛋白激酶Cδ与药理机械偶联：重新审视脑血管控制机制
Nadia Haghbin,Michelle S M Kim,Mohammed El-Lakany et al.
Nadia Haghbin et al.
Constrictor stimuli set arterial tone through coupling processes dependent (electromechanical) and independent (pharmacomechanical) of VM. As the latter receives limited attention, we conducted a focused examination of the cerebral circulat...
Improved subjective sleep quality in older adults by enhancing the GABAergic system in the sensorimotor cortex [0.03%]
通过增强感觉运动皮层的GABA能系统改善老年人主观睡眠质量
Selin Scherrer,Sven Egger,Xinyu Liu et al.
Selin Scherrer et al.
Sleep disturbances affect nearly half of all adults aged 60 and above, reducing quality of life and contributing to various health issues. While pharmacological treatments enhancing GABAergic activity can improve sleep, they often have adve...
Fasting-induced glucose intolerance is not impacted by the addition of daily exercise: A randomized crossover study [0.03%]
每日添加运动不会影响断食诱导的血糖耐受不良：一项交叉随机试验
Tori Bouck,Alexis Marcotte-Chénard,Darren Barg et al.
Tori Bouck et al.
Short-term fasting (48-72 h) impairs insulin sensitivity and glucose tolerance, but it is unclear if aerobic exercise - which is known to have insulin-sensitizing effects - can attenuate fasting-induced decrements in glucose homeostasis. To...
Gerardo Bosco,Richard E Moon,Enrico M Camporesi et al.
Gerardo Bosco et al.
Systems modelling of mitochondrial dynamics in different exercise regimes [0.03%]
不同运动模式下的线粒体动态系统模型研究
Ali Khalilimeybodi,Lingxia Qiao,Allen Leung et al.
Ali Khalilimeybodi et al.
Exercise stimulates skeletal muscle signalling and mitochondrial metabolism. Emerging evidence shows that mitochondrial dynamics (i.e. fission and fusion) could be regulated by exercise. Yet, key gaps remain in identifying (i) the signals t...
Central leptin resistance precedes obesity and drives early endocrine dysfunction [0.03%]
中心瘦素抵抗先于肥胖并引发早期内分泌功能障碍
Amanda Abreu Avelino,Larissa Moreira Dias
Amanda Abreu Avelino
Decoding the molecular memory of obesity using machine learning and microRNA dynamics [0.03%]
运用机器学习和microRNA动力学解码肥胖的分子记忆
Gaetano Santulli,Urna Kanskar,Stanislovas Jankauskas et al.
Gaetano Santulli et al.
Kinematic-calcium loops unravel impaired excitation-contraction coupling in MELAS-affected cardioids [0.03%]
动能-钙循环解开MELAS影响的心细胞兴奋收缩缺陷机制
Margherita Burattini,Annalinda Pisano,Maria Gemma Pignataro et al.
Margherita Burattini et al.
Impaired Ca2+ handling, and in particular leakage from the sarcoplasmic reticulum, is a critical mechanism in metabolic diseases affecting the heart. Phase-plane loop analysis provides an integrated assessment of excitation-contraction coup...