Regulation of basal and tumour necrosis factor α-induced fibroblast gene expression by peptidylarginine deiminase 2 [0.03%]
肽基精氨酸脱亚胺酶2调节正常和肿瘤坏死因子α诱导成纤维细胞基因表达
Mohammad Aslam Saifi,Flavien Marguerie,Mari Kamiya et al.
Mohammad Aslam Saifi et al.
Fibroblasts exhibit organ-specific function and in response to tumour necrosis factor α (TNFα) can produce a large amount of inflammatory mediators, including interleukin-6 (IL-6), partly via a leukaemia inhibitory factor (LIF) autocrine ...
Demonstration of beat-to-beat, on-demand ATP synthesis in ventricular myocytes reveals sex-specific mitochondrial and cytosolic dynamics [0.03%]
心室肌细胞中瞬时ATP合成的演示揭示了性别特异性的线粒体和胞质动态变化
Paula Rhana,Collin Matsumoto,L Fernando Santana
Paula Rhana
The energetic demands on ventricular myocytes imposed by the transport of ions and cross-bridge cycling are well known, yet the spatiotemporal dynamics of ATP supply and demand remain poorly understood. Here, using confocal microscopy and g...
Pharmacological manipulation of the immediate effects of spinal trauma in neonatal rats reveals a crucial role for TRPV4 receptors [0.03%]
药理学操纵脊髓损伤的即时效应显示TRPV4受体的关键作用
Atiyeh Mohammadshirazi,Caterina Ciani,Francesca Emma Mongelli et al.
Atiyeh Mohammadshirazi et al.
Physical trauma to the spinal cord causes a massive depolarising injury potential (DIP), transient spinal hypoxia and extensive cell loss at the injury site, disrupting conduction along white matter tracts. This leads to transient hypotonia...
Sex- and age-dependent differences in detrimental repolarization-prolonging effects of doxorubicin: Evidence of cardiac toxicity beyond heart failure [0.03%]
性别和年龄依赖性的多柔比星延长复极的不利效应差异：心脏毒性超出心力衰竭的证据
Miriam Barbieri,Katja E Odening
Miriam Barbieri
Ageing does not impair motor neuron adaptations: comparable motor unit responses to strength training in young and older adults [0.03%]
老化不会影响运动神经元的适应：年轻和年老成年人的力量训练后运动单位的反应相当
Andrea Casolo,Stefanie Del Vecchio,Benjamin I Goodlich et al.
Andrea Casolo et al.
Ageing induces structural and functional changes in the neuromuscular systems that impair voluntary force production, compromising daily function and wellbeing. We examined whether older adults preserve the capacity for motor unit adaptatio...
Acute cardio-centric haemodynamic management preserves chronic cardiovascular function in pigs with high-thoracic spinal cord injury [0.03%]
急性心血管中心性血液动力学管理可保护高胸段脊髓损伤猪的慢性心脏功能
Alexandra M Williams,Neda Manouchehri,Keerit Tauh et al.
Alexandra M Williams et al.
Chronic high-level spinal cord injury (SCI) leads to a complex phenotype of long-term cardio-autonomic dysregulation. In the initial hours post-injury, cardio-centric management with dobutamine (DOB) can optimize cardiovascular haemodynamic...
Neuroscience of the premotor cortex: Implications for motivation shaping attention-motor interactions [0.03%]
背侧前运动皮层在动机调节注意力-运动交互中的作用及其神经机制
Sunny Cui,Vedant Tapiavala,Stephen Kim et al.
Sunny Cui et al.
Maternal obesity induces activator protein 1-mediated inflammatory response to impair embryonic neurogenesis [0.03%]
母体肥胖通过活化蛋白1介导的炎症反应损害胚胎神经发生
Li-Wei Chen,Md Nazmul Hossain,Yao Gao et al.
Li-Wei Chen et al.
Maternal obesity (MO) is a growing global problem, which poses significant risks to fetal neurodevelopment and long-term neurological functions of offspring, but the underlying molecular mechanisms remain to be established. To address this ...
Deconvoluting fibre type proportions from human skeletal muscle transcriptomics and proteomics data using FibeRtypeR [0.03%]
基于人类骨骼肌转录组和蛋白质组数据使用FibeRtypeR解卷积纤维类型比例
Thibaux Van der Stede,Roger Moreno-Justicia,Freek Van de Casteele et al.
Thibaux Van der Stede et al.
Muscle fibres are the dominant, multinucleated cell type in skeletal muscle. In humans, they can be classified as slow (type 1) and fast (type 2) fibres, traditionally based on distinct properties of their contractile machinery. Slow and fa...
Neuromuscular fatigability with repeated exercise in hypoxia: From single-joint paradigms to sprints [0.03%]
重复低氧运动对神经肌肉疲劳的影响：从单关节模式到短跑冲刺
Luca Ruggiero,Franck Brocherie,Olivier Girard et al.
Luca Ruggiero et al.
Acute hypobaric or normobaric hypoxic exposure (i.e. inspired oxygen pressure