Obesity, microRNA circulating microRNA signatures reveal core and reversible dysregulations in obesity via machine learning [0.03%]
肥胖microRNA循环microRNA特征通过机器学习揭示肥胖的核心和可逆的调节失调
Yuan Yue,Rajesh Katare,Jeremiah Deng et al.
Yuan Yue et al.
Obesity is a complex metabolic disease characterized by systemic metabolic and inflammatory dysregulation, yet the molecular signatures underlying these processes remain incompletely understood. Circulating microRNAs (miRNAs) have emerged a...
TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour [0.03%]
转运蛋白TMEM16A氯通道在女性生殖道中的作用及其在正常和异常妊娠和分娩中的作用
Helena C Parkington,Harold A Coleman,Penelope M Sheehan et al.
Helena C Parkington et al.
Female fertility relies heavily on the health of the oviduct and uterus. Each of these organs consist of a muscular tube lined by epithelial cells. In this review, we discuss the role of the TMEM16A chloride ion channel, expressed in the ep...
Peripheral cholecystokinin promotes thermogenesis via vagal afferent signalling, hypothalamic oxytocin and sympathetic outflow to brown adipose tissue [0.03%]
迷走传入介导的外周胆囊收缩素促进下丘脑催产素和交感神经对棕色脂肪组织的作用以产生热量
Yuta Masuda,Miyuki Kawase,Rika Kitano et al.
Yuta Masuda et al.
Thermoregulation is essential for survival in homeothermic animals. Vagal sensory nerves are well known to detect visceral signals and regulate feeding and metabolic functions, but their role in thermoregulation remains poorly understood. C...
Sex and age shape acute doxorubicin-induced electrical remodelling in the heart [0.03%]
性别和年龄对心脏急性多柔比星诱导的电重塑的影响
Savia Christina Pereira Bueno
Savia Christina Pereira Bueno
Different effects of 3-week disuse on phenotype and gene expression in calf and thigh muscles [0.03%]
小腿和大腿肌肉失用3周后表型和基因表达的差异性变化
Mira A Orlova,Nadia S Kurochkina,Roman Yu Zhedyaev et al.
Mira A Orlova et al.
Disuse, like several other pathological conditions, has specific effects on various skeletal muscles; the mechanisms underlying these responses remain unclear. We aimed to compare the disuse-induced changes in the phenotype and proteome of ...
Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet-induced obesity [0.03%]
Δ9四氢大麻酚和大麻提取物可改善饮食诱导的肥胖患者的脂毒性胰岛功能障碍
Bryant Avalos,Martin Olmos,Courtney P Wood et al.
Bryant Avalos et al.
Diet-induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS) function. Acute cannabis consumption stimulates appetite; however, chronic consumption is paradoxically associated with lower pre...
Erg currents support electrical bursting in murine anterior pituitary corticotrophs [0.03%]
内向整流钾电流对小鼠垂体前叶促肾上腺皮质激素细胞电爆发放电的调控作用
Sooraj V Nair,Nicola Romanò,Peter J Duncan et al.
Sooraj V Nair et al.
The regulation of electrical excitability of anterior pituitary corticotrophs is critical for an appropriate response of the hypothalamic-pituitary-adrenal (HPA) axis in the face of diverse physiological challenges in health and disease. Ho...
Heat acclimation improves the neural control of body temperature during heat stress in older adults [0.03%]
热适应改善了老年人在热应激下的体温神经控制能力
Thomas A Deshayes,Hadiatou Barry,Amine Dahhak et al.
Thomas A Deshayes et al.
The mechanisms underlying impaired temperature regulation in older age, and the ability of older adults to physiologically adapt to heat exposure remain understudied. This study determined the effects of older age on the neural control of b...
Calcium-activated chloride channels in pericytes and their role in regulating organ blood flow [0.03%]
周细胞氯通道及其调节器官血流的作用
Paolo Tammaro,Hikaru Hashitani
Paolo Tammaro
Pericytes are mural cells of the microvasculature, characterised by a distinctive 'bump-on-a-log' morphology and elongated processes extending along the abluminal surface of capillary and pre- and post-capillary segments. They are widely di...