Testosterone modulates multispectral oscillatory activity serving performance of motor sequences in typically developing youth [0.03%]
睾酮调节典型发育青年运动序列表现的多光谱振荡活动
Jackson Derby,Thomas W Ward,Nathan M Petro et al.
Jackson Derby et al.
Motor control is critical to daily functioning and undergoes significant refinement throughout youth. Although the effects of age on the underlying brain circuitry have been well characterized, fewer studies have examined the influence of p...
Oxygen and glucose supplementation increases rates of linear growth and cell proliferation in growth-restricted fetal sheep [0.03%]
富氧和葡萄糖补充增加生长受限胎儿羊线性生长速度和细胞增殖速率
Mariangel Varela,Daniel B Chrisenberry,Eliza H Johnson et al.
Mariangel Varela et al.
Placental insufficiency lowers oxygen and glucose concentrations in the fetus, which causes fetal growth restriction (FGR). Previously we showed that FGR fetuses chronically supplemented with oxygen and glucose (OG) have improved glucose to...
Heart rate phase is an indicator of chronotype-relevant circadian shifts associated with human disease: an All of Us Research Program analysis [0.03%]
心率相位是与人类疾病相关的与时型有关的昼夜节律变化的指标：来自“全民参与研究计划”的分析结果
Zachary M Chan,Priya P Patel,Gabriella M Levitsky et al.
Zachary M Chan et al.
Chronotype describes an individual's day or night preference and is thought to exert health effects through circadian timing, yet continuous circadian measures related to chronotype have never been examined in large human cohorts. We sought...
Affective CT-touch attenuates cortical responses and subjective attention during temporal summation of second pain [0.03%]
情感型CT触摸缓解二次痛的时间累积的皮层反应和主观注意力
Márcia da-Silva,A Ribeiro-Carreira,Mariana Oliveira et al.
Márcia da-Silva et al.
The activation of C-tactile (CT) mechanoreceptors is typically experienced as pleasant touch and has been proposed to have analgesic effects. However, its influence on central sensitization across social and non-social contexts remains uncl...
TMEM16A channel signalling microdomains in the regulation of vascular function [0.03%]
TMEM16A通道信号微域在血管功能调节中的作用
Fênix Araujo,Swapnil K Sonkusare
Fênix Araujo
Among the various chloride channel subtypes expressed in vascular tissues, Ca2+-activated chloride channels (CaCCs) have been most extensively studied for their critical role in linking intracellular Ca2+ signalling to changes in membrane p...
Treating age-related loss of muscle mass and function: Where should we be focusing? [0.03%]
如何治疗与年龄有关的肌肉萎缩和功能障碍？我们应该关注什么？
Daniel J Ham,Christopher S Fry,Avnika Ashok Ruparelia et al.
Daniel J Ham et al.
Increased life expectancy across developed countries has highlighted the personal and societal value of healthy ageing. A well-functioning neuromuscular system is fundamental to quality of life and functional independence. The systemic dete...
Sarcolemmal and mitochondrial membrane potentials measured ex vivo and in vivo in the heart by pharmacokinetic modelling of [99mTc]sestamibi [0.03%]
药代动力学模型在心肌[Sestamibi-99mTc]摄取下的离体和在体心脏细胞膜及线粒体膜电位测定
Edward C T Waters,Friedrich Baark,Matthew R Orton et al.
Edward C T Waters et al.
Transmembrane electrical potentials across the sarcolemmal ( E m ${{E}_{/mathrm{m}}}$ ) and mitochondrial ( Δ Ψ m $/Delta {{{{/Psi}}}_{/mathrm{m}}}$ ) membranes are central to cellular excitability, metabolism and viability. ...
α-Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons [0.03%]
α-突触核蛋白寡聚体通过增加中脑多巴胺能神经元的Cav2.2电流来降低动作电位发放并增强多巴胺释放
Giulia Tomagra,Anthony Battaglia,Claudio Franchino et al.
Giulia Tomagra et al.
The spontaneous firing activity of substantia nigra (SN) dopaminergic (DA) neurons is finely tuned by the autocrine inhibition mediated by D2 DA autoreceptors (D2-ARs) that activate GIRK2 channels. Despite this regulatory mechanism, the vul...
Neuronal loss of the pentose phosphate pathway in the living nervous system is causally linked to [NADPH] reduction and elevated oxidative stress [0.03%]
活体神经系统中戊糖磷酸途径的神经元损失与[NADPH]减少和氧化应激升高存在因果关系
Stephan Müller,Nina Surina,Andrés Köhler-Solís et al.
Stephan Müller et al.
Neurons are highly specialized cells that require large amounts of energy to function. Glial cells support neurons in many ways, including metabolically. In Drosophila, neuronal glycolysis has been found to be dispensable, as long as glial ...
How to view the autonomic nervous system as physiologist, anatomist and pharmacologist? [0.03%]
从生理学、解剖学和药理学的角度如何看待自主神经系统？
John M Karemaker
John M Karemaker