Chronic attenuation of brain leptin signalling is associated with early metabolic dysfunction in lean rats [0.03%]
瘦型大鼠慢性脑内瘦素信号减弱与早期代谢功能障碍有关
Cristina Pintado,Lorena Mazuecos,Óscar Gómez-Torres et al.
Cristina Pintado et al.
Brain leptin signalling plays a central role in the regulation of energy balance and glucose homeostasis, yet its contribution to early metabolic dysfunction preceding overt obesity remains uncertain. In the present study, we examined the m...
Braking bad: do environmental hypoxia and contractile activity really work well together to support muscle angiogenesis? [0.03%]
环境缺氧和收缩活动真的能够很好地协同促进肌肉血管生成吗？
Emilie Roudier,Pierre Lemieux
Emilie Roudier
Human placental exposure to pollutant nanoparticles: uptake, translocation and functional impact [0.03%]
污染物纳米颗粒对胎盘的暴露：吸收、转运和功能影响
Katherine L Bethell,Andrew C Povey,Edward D Johnstone et al.
Katherine L Bethell et al.
Nanoparticles are abundant in the natural environment as a result of an exponential increase in the production of engineered particles and pollutants. Due to their small size, nanoparticles can cross mucosal barriers, entering the blood str...
The deletion of HSP60 in cholinergic neurons alleviates LPS-induced depressive-like behaviours in mice by reducing neuroinflammation [0.03%]
胆碱能神经元中热休克蛋白60的缺失通过减少神经炎症缓解小鼠LPS诱导的抑郁样行为
Xiangzan Wei,Xiaoni Zhong,Yu Ouyang et al.
Xiangzan Wei et al.
Depression is a significant global health issue characterized by complex underlying mechanisms. This study aimed to investigate the role of cholinergic neuron-specific heat shock protein 60 (HSP60) in modulating lipopolysaccharide (LPS)-ind...
Modulation of pain by affective touch: effects of childhood trauma, depression, chronic pain, and spinal segment [0.03%]
情感触觉对疼痛的调节作用：儿童创伤、抑郁、慢性疼痛和脊髓节段的影响
Benedetta Albinni,Marisa Zimmerman,Vincent Alasha et al.
Benedetta Albinni et al.
Chronic pain is highly prevalent, and non-pharmacological tools are a crucial part of a multimodal approach to reducing burden of pain. Among these touch-based interventions such as massage have long been popular, yet their underlying pain-...
Jack Corbett,Richard P Hulse
Jack Corbett
Hypoxia exerts a strong influence on nervous system behaviour, with its effects most apparent in tissues where metabolic demand is high. This includes the somatosensory system. The stability of metabolic processes within nociceptive neural ...
Is oxysterol accumulation a central physiological trigger of inflammaging? [0.03%]
氧化固醇堆积是促炎衰老的生理触发因素吗？
Nila Ganamurali,Sarvesh Sabarathinam
Nila Ganamurali
Parasympathetic overdrive as a cause of overactive bladder in a high-fat-diet-induced obesity mouse model [0.03%]
高脂饮食诱导的肥胖小鼠模型中副交感神经功能亢进导致的膀胱过度活动症
Ayu Sugiura,Retsu Mitsui,Kyoko Miwa-Nishimura et al.
Ayu Sugiura et al.
Overactive bladder (OAB) is a highly prevalent condition characterized by urinary urgency that negatively affects quality of life. Because obesity and metabolic syndrome (MetS) are known as major risk factors for OAB, we explored the mechan...
Mitochondrial dynamics and oxidative metabolism: an emerging role for Septin7 in skeletal muscle [0.03%]
线粒体动力学和氧化代谢：Septin7在骨骼肌中的作用不容忽视
Márcio Augusto Campos-Ribeiro,Rudá Prestes E Albuquerque,Thiago N Menezes et al.
Márcio Augusto Campos-Ribeiro et al.
Breathing irregularities and postnatal hypoxaemia in an experimental model of essential hypertension [0.03%]
一种必要性高血压实验模型中的呼吸紊乱及出生后的低血氧症
Beatriz N Vieira,Letícia R Mendes,Sarah G Mariano et al.
Beatriz N Vieira et al.
Essential hypertension remains a major global health problem with poorly defined mechanisms. Increased vascular sympathetic activity and sleep-disordered breathing are common features in hypertensive patients and adult spontaneously hyperte...