Vaughan G Macefield
Vaughan G Macefield
Fast and slow skeletal muscle: Different overall activation levels and kinetics of myosin motors underlie muscle type-specific contractile properties [0.03%]
快慢骨骼肌：肌球蛋白马达整体激活水平和动力学的差异决定了肌肉类型的特异性收缩性质
Daniel Z Kruse,Jon Herskind,Angelos Angelidis
Daniel Z Kruse
Ultrasound-based haemodynamic force trajectories in a murine model of reversible pressure overload [0.03%]
基于超声的血流动力学力在可逆性压力负荷小鼠模型中的变化轨迹
Peyton M Day,Thomas Moore-Morris,Craig J Goergen et al.
Peyton M Day et al.
Haemodynamic forces (HDF) quantify intraventricular pressure gradients as integrated vectors derived from myocardial motion and blood flow, providing a sensitive marker of left ventricular (LV) remodelling beyond conventional metrics such a...
Estimation of persistent inward currents contribution to inspiratory motoneuron firing in humans [0.03%]
人持久内向电流对吸气运动神经元放电的贡献估计
Ricardo N O Mesquita,Simon C Gandevia,Janet L Taylor et al.
Ricardo N O Mesquita et al.
Persistent inward currents (PICs) are known to prolong firing of limb-muscle motoneurons. Although there is immunohistochemical evidence of PIC channels in respiratory motoneurons, it is unknown whether PICs contribute to their firing prolo...
Appetite stimulation versus metabolic regulation: Medicinal Cannabis as a pharmacological strategy for weight loss [0.03%]
Appetitive刺激与代谢调节：医用大麻的药理策略在减肥中的作用
Marcela Coffacci de Lima Viliod
Marcela Coffacci de Lima Viliod
Sarah A Marshall
Sarah A Marshall
Peripheral regeneration of Aβ low-threshold mechanoreceptors is limited despite activation of regenerative transcriptional pathways [0.03%]
尽管激活了再生转录途径，但Aβ低阈值机械感受器的周围神经再生是有限的
Sara Bolívar,Natàlia Martínez-Mateu,David Ovelleiro et al.
Sara Bolívar et al.
Peripheral neurons can regenerate after nerve injury, yet functional recovery is often incomplete due to non-specific or incomplete target reinnervation. Among sensory neuron subtypes, Aβ low-threshold mechanoreceptors (Aβ-LTMRs) mediate ...
Pancreatic cancer cachexia promotes cardiac dysfunction through altered adrenergic signalling in the heart [0.03%]
胰腺癌恶病质通过改变心脏肾上腺素能信号促进心功能障碍
Parham Diba,Peter R Levasseur,Samuel D Newton et al.
Parham Diba et al.
Cancer cachexia is a metabolic syndrome commonly observed in patients with pancreatic ductal adenocarcinoma (PDAC), characterized by wasting of skeletal and cardiac muscle. This condition is associated with the neurohormonal stress response...
Multifactorial nature of anabolic resistance in ageing skeletal muscle: A systems modelling study [0.03%]
衰老骨骼肌合成阻力的多因子特征及其系统建模研究
Taylor J McColl,Daniel R Moore,Eldon Emberly et al.
Taylor J McColl et al.
Sarcopenia, the age-related loss of skeletal muscle mass and function, is primarily caused by anabolic resistance, which is the blunted stimulation of muscle protein synthesis (MPS) and impaired suppression of muscle protein breakdown follo...
FGF12A confers calcium sensitivity to Nav1.5 inactivation via dynamic calmodulin recruitment [0.03%]
FGF12A通过动态结合钙调蛋白赋予Nav1.5失活对钙的敏感性
Lucy Woodbury,Anna Li,Paweorn Angsutararux et al.
Lucy Woodbury et al.
Voltage-gated Na+ (Nav) channels, including Nav1.5, initiate cardiac and neuronal action potentials. Regulation of Nav1.5 inactivation is linked to multiple accessory proteins that bind its C-terminal domain (CTD), including calmodulin (CaM...