Matching sodium channel availability to resting membrane potential: Biophysical logic across excitable cell types [0.03%]
Mohammad-Reza Ghovanloo,Stephen G Waxman
Mohammad-Reza Ghovanloo
Excitable tissues like the brain, peripheral nerves, skeletal muscles and the heart share a common dependence on voltage-gated sodium (Nav) channels for the initiation and propagation of action potentials (APs). These Nav channels exhibit u...
Luis Gustavo A Patrone,Luciane H Gargaglioni
Luis Gustavo A Patrone
Cannabinoid use during pregnancy has risen worldwide in recent years, driven by both recreational use and perceived therapeutic benefits. While most existing research has concentrated on neuropsychiatric outcomes and structural or functiona...
Altered functional interactions between CFTR disease mutants ΔF508 and G551D and the protein kinase A catalytic subunit [0.03%]
Olivér Závoti,Márton A Simon,László Csanády
Olivér Závoti
The epithelial anion channel cystic fibrosis transmembrane conductance regulator (CFTR) is activated by cAMP-dependent protein kinase (PKA). PKA stimulates CFTR channels through two mechanisms: non-catalytically, by binding to the channel, ...
Yanyu Zhang
Yanyu Zhang
Longer action potential duration in the Purkinje network than in the ventricular myocardium delays retrograde activation of the human His-Purkinje system [0.03%]
Jason D Bayer,Edward J Vigmond,Ruben Coronel et al.
Jason D Bayer et al.
His-Purkinje system (HPS) activation during programmed electrical stimulation is delayed in patients susceptible to ventricular arrhythmias. Its mechanism and clinical relevance are unknown. We hypothesized that longer action potential dura...
Sex-dependent activation of apamin-sensitive small-conductance Ca2+-activated K+ current by β1-adrenergic stimulation in rabbit ventricles [0.03%]
Minjing Yang,Liyang Zhang,Anxhela Kote et al.
Minjing Yang et al.
We previously found that isoproterenol activates apamin-sensitive small-conductance Ca2+-activated K+ currents (IKAS) more in female than male rabbit ventricles. Isoproterenol activates all β-adrenoceptors (ARs). It remains unknown which A...
Response to the opinion paper by Bouchama (2025), entitled 'Redefining human heat limits: integrating molecular and evolutionary physiology' [0.03%]
Philémon Marcel-Millet,Matthew N Cramer,Léa Tuifua et al.
Philémon Marcel-Millet et al.
Suyash Mehta,Cushla McGoverin
Suyash Mehta
Differential negative dominance by KCNA2 variants associated with global developmental delay suggests KCNA2 haploinsufficiency in humans [0.03%]
Pei Xin Boon,Amaia Jauregi-Miguel,S Suheda Yasarbas et al.
Pei Xin Boon et al.
KCNA2 encodes the pore-forming subunits of the voltage-gated, potassium-selective channel KV1.2, which controls the excitability of both central and peripheral neurons. Either gain- or loss-of-function KCNA2 variants can cause severe neurol...
Muscle tendon vibration revisited: Why tonic vibration reflex and kinaesthetic illusions matter [0.03%]
Nicolas Amiez,Louis-David Beaulieu,Christos Paizis et al.
Nicolas Amiez et al.
Muscle-tendon vibration (MTV) has long been employed in both experimental and clinical settings, and its interest as a neurorehabilitation tool continues to grow. Yet, two primary physiological responses elicited by MTV, the tonic vibration...