Circular RNAs: Unlocking new avenues in cardiometabolic disease management [0.03%]
循环RNA在心血管代谢性疾病的治疗中的新作用
Kimberley M Mellor,Thomas D Donelly,Gerald L M Naepi et al.
Kimberley M Mellor et al.
Cardiometabolic diseases refer to a group of interrelated conditions that affect both the cardiovascular system and metabolic processes. These conditions represent a significant global health burden and often share common risk factors such ...
Intercalated disk structure, tissue heterogeneity and ion channel distribution modulate conduction and local calcium influx [0.03%]
闰盘结构、组织异质性和离子通道分布调节传导和局部钙离子内流
Nicolae Moise,Heather L Struckman,James W Smyth et al.
Nicolae Moise et al.
The intercalated disk (ID) is the specialized cellular structure that connects cardiomyocytes. Electrogenic proteins are known to be preferentially located at the ID, such as the voltage-gated sodium channel (NaV1.5), inward-rectifying pota...
Intramuscular neutrophil-derived immunometabolic niches locally boost insulin-responsive GLUT4 translocation after muscle contraction [0.03%]
肌肉收缩后肌内中性粒细胞源免疫代谢生态位局部促进胰岛素反应型葡萄糖转运蛋白4转位
Weijian Chen,Makoto Kanzaki
Weijian Chen
Exercise is well known to enhance insulin sensitivity in skeletal muscle, yet the underlying mechanisms remain incompletely understood. We have previously shown that neutrophil recruitment contributes to contraction-induced GLUT4 translocat...
Cortical responses to balance perturbations persist without active postural control [0.03%]
在没有主动姿势控制的情况下，平衡扰动的大脑皮层反应仍然存在
Daphne N R Jansen,Lucas Mensink,Matto Leeuwis et al.
Daphne N R Jansen et al.
Standing balance relies on rapid reflexes as well as longer-latency subcortical and cortical processes to generate corrective responses to postural disturbances. EEG studies consistently identify two perturbation-evoked markers of cortical ...
Females exhibit greater cardiac volume reductions with expiratory muscle loading during submaximal exercise compared to males [0.03%]
与男性相比，女性在亚极量运动时呼气肌负荷下心脏容积减少更明显
Sarah A Angus,Michelle Ottlik,Connor J Doherty et al.
Sarah A Angus et al.
Intrathoracic pressure (ITP) modulates venous return, ventricular filling and ejection throughout the respiratory cycle, and its fluctuations are accentuated during exercise. We sought to determine whether ITP manipulation during submaximal...
Update on cellular expression and function of ANO1 channels in urethral smooth muscle [0.03%]
尿道平滑肌中ANO1通道的细胞表达和功能的新进展
Bernard T Drumm,Neha Gupta
Bernard T Drumm
Urinary continence is maintained by the cooperation of smooth and striated muscles where urethral smooth muscle cell (USMC) contractions contribute to resting urethral tone during bladder filling, whereas striated muscle contracts in respon...
Ascl3+ ionocytes in murine salivary gland ducts are innervated sensory cells that display unique calcium signalling characteristics and contribute to the composition of saliva [0.03%]
Ascl3+离子细胞是腮腺导管中的神经感觉细胞并具有独特的钙信号特征，参与唾液组成的调节
Hitoshi Uchida,Eri O Maruyama,Takahiro Takano et al.
Hitoshi Uchida et al.
Ionocytes are distinct epithelial sensory cells scattered throughout the ductal system of the salivary glands. These cells are distinguished by their unusual morphology, as well as by a specific transcriptomic signature that includes the ex...
Age-related decline in NCKX4-mediated calcium clearance accelerates aortic remodelling and drives early vascular ageing [0.03%]
与年龄相关的NCKX4介导的钙清除作用下降加速主动脉重塑并导致早期血管衰老
Guilherme H Souza Bomfim,Kesava Asam,Nish Patel et al.
Guilherme H Souza Bomfim et al.
Ageing is the primary non-modifiable risk factor for cardiovascular diseases (CVDs), with older women facing a greater risk of CVDs than age-matched men. Vascular smooth muscle cells (VSMCs) dysfunction and impaired calcium (Ca2+) handling ...
The sympathoregulatory region of the mouse rostral brainstem relies on both GABA and glycine to generate inhibitory currents [0.03%]
小鼠延髓头端部的交感神经调节区依赖于GABA和甘氨酸产生抑制电流
Hong Gao,Lucie D Desmoulins,Adrien J R Molinas et al.
Hong Gao et al.
Presympathetic neurons in the ventrolateral and ventromedial medulla (VLM/VMM) control sympathetic tone, and GABA and glycine were identified as inhibitory neurotransmitters. Although glycinergic inhibition of presympathetic neurons in the ...
Mark Potse
Mark Potse