Maternal cardiometabolic dysfunction and fetal sex-specific alterations to uterine vascular reactivity in an ovine model of obesity during pregnancy [0.03%]
母体心代谢功能障碍和肥胖孕妇胎儿性别特异性的子宫血管反应性改变的卵形模型
Rachael C Crew,Anna L K Cochrane,Youguo Niu et al.
Rachael C Crew et al.
Obesity during pregnancy is at pandemic proportions and predisposes women to pre- and postnatal cardiovascular dysfunction. The mechanisms underlying this maternal cardiovascular vulnerability remain unclear, partly due to a lack of transla...
Restoration of neuromuscular function by mitochondrial transplantation in injured mouse skeletal muscle [0.03%]
线粒体移植修复受损小鼠骨骼肌的神经肌肉功能
Stephen E Alway,Peter J Ferrandi,Hector G Paez et al.
Stephen E Alway et al.
Rehabilitative activity can improve injury repair, but it risks additional damage and reduces the functional recovery of regenerating muscle. This study tested the hypothesis that moderate electrically evoked contractions would slow restora...
Glucose and fructose contributions to exogenous carbohydrate oxidation and performance at moderate altitude [0.03%]
葡萄糖和果糖对中等海拔条件下外源碳水化合物氧化及运动表现的贡献
Nicola C Arjomandkhah,Andy J King,Alex Griffiths et al.
Nicola C Arjomandkhah et al.
The ingestion of fructose with glucose has been shown to enhance exogenous carbohydrate oxidation during exercise at sea level compared with glucose alone. Whether this synergistic effect occurs at altitude is yet to be established. This st...
Caloric restriction and aerobic exercise differentially counteract muscle-tendon dysfunction following diet-induced obesity in C57BL/6J mice [0.03%]
有氧运动和热量限制对C57BL/6J肥胖小鼠肌肉肌腱功能障碍的缓解作用不同
Leonardo Cesanelli,Petras Minderis,Andrej Fokin et al.
Leonardo Cesanelli et al.
Obesity profoundly impairs musculotendinous structure and function, but the extent to which these alterations can be reversed remains unclear. This study compared the effects of aerobic exercise (EX) and caloric restriction (CR) on the reco...
Tauroursodeoxycholic acid (TUDCA) ameliorates age-related skeletal muscle loss [0.03%]
牛胆酸可通过改善年老小鼠肌肉干细胞的有丝分裂和线粒体功能来缓解年龄相关的肌肉损失
Marina S Carvalho,Leticia Barssotti,Lohanna M B Dos Santos et al.
Marina S Carvalho et al.
Ageing leads to changes in body composition, including increased adiposity and reduced skeletal muscle mass and force. The alterations in ageing skeletal muscle result from impaired proteostasis driven by factors such as chronic inflammatio...
Low-threshold cutaneous mechanoreceptors on the foot sole have enhanced sensitivity when skin temperature is elevated [0.03%]
足底皮肤温度升高时机械感受器的敏感性增强
Erika E Howe,Michael Apollinaro,Joanna Reeves et al.
Erika E Howe et al.
Cutaneous mechanoreceptor input from the foot sole is critical for balance and gait, yet ageing and disease can compromise skin sensitivity, increasing risks for falls and related injuries. Heating improves perceptual sensitivity, but its d...
Seasonal shifts in mitochondrial and reactive oxygen species metabolism are linked to ultrastructural remodelling in honey bees (Apis mellifera) [0.03%]
与氧化能量代谢和活性氧物种有关的季节性变化与意蜂(Optima mella rna sily)超微结构重塑相关联
Adèle Léger,Mélanie Aminot,Samuel Robichaud et al.
Adèle Léger et al.
Domesticated honey bees (Apis mellifera) remain highly active year-round, even in northern climates, requiring a tight regulation of their energetic metabolism. However, the overwintering process, particularly the mitochondrial mechanisms s...
Amino acid modulation of the carotid body selectively modulates peripheral chemoreceptor respiratory reflex [0.03%]
氨基酸调节颈动脉体对周围化学感受器呼吸反射的选择性调节作用
Olivia M S Gold,Audrys G Pauza,Igor S A Felippe et al.
Olivia M S Gold et al.
Cardiorespiratory homeostasis is maintained by carotid body (CB) peripheral chemoreceptors that monitor blood oxygen and stimulate breathing. While proportionality between peripheral chemoreflex sensitivity and respiratory response is relat...
Human multi-tissue transcriptomics identifies galectin-1 and follistatin-like 1 as exerkines with distinct transcript-to-serum coupling after exercise [0.03%]
人类多组织转录组学识别出半乳糖凝集素-1和促性腺激素抑制素样蛋白1为运动后具有不同转录本到血清耦合特性的运动力相关因子
Jaeseung Song,Eun-Suk Cho,Yu Rim Kwon et al.
Jaeseung Song et al.
Exercise-induced secreted factors (exerkines) are proposed to coordinate systemic health benefits, yet their human tissue sources and the physiological rules governing transcript-to-serum coupling remain incompletely defined. We integrated ...