Gustavo Balbinot,Matija Milosevic,Cindi M Morshead et al.
Gustavo Balbinot et al.
The central and peripheral nervous systems are specialized to conduct electrical currents that underlie behaviour. When this multidimensional electrical system is disrupted by degeneration, damage, or disuse, externally applied electrical c...
An α7 nicotinic and GABAB receptor-mediated pathway controls acetylcholine release in the tripartite neuromuscular junction [0.03%]
一个由α7烟碱型乙酰胆碱受体和GABAＢ受体介导的通路控制三联体神经肌肉接头中的乙酰胆碱释放
Konstantin Petrov,Oksana Lenina,Jacqueline Leroy et al.
Konstantin Petrov et al.
Terminal Schwann cells (TSCs) are capable of regulating acetylcholine (ACh) release at the neuromuscular junction (NMJ). We have identified GABA as a gliotransmitter at mouse NMJs. When ACh activates α7 nicotinic ACh receptor (nAChRs) on T...
Heartificial intelligence: smart solutions for CHF: An A(I)MT approach [0.03%]
人工心脏智能：心衰的智慧解决方案：A(I)MT方法论
Samuel Gillman,Irving H Zucker,Han-Jun Wang
Samuel Gillman
Excessive hypercholesterolaemia during pregnancy as a risk factor for endothelial dysfunction in pre-eclampsia [0.03%]
妊娠期胆固醇水平过高是先兆子痫内皮功能障碍的风险因素
Amanda A de Oliveira,Floor Spaans,Christy-Lynn M Cooke et al.
Amanda A de Oliveira et al.
Pregnancy induces significant changes in the maternal cardiovascular system, and insufficient vascular endothelial adaptations to pregnancy contribute to the development of pregnancy complications such as pre-eclampsia. Pre-eclampsia is not...
Chloride reported missing from brain and extracellular matrix is a suspect [0.03%]
脑和细胞外基质中失踪的氯化物成为嫌疑人
Charles Nicholson
Charles Nicholson
Influence of pericardium on ventricular mechanical interdependence in an isolated biventricular working pig heart model [0.03%]
隔膜心包对分离双心室作用的猪心脏模型中室性机械相互依赖的影响
Fanny Vaillant,Emma Abell,Laura R Bear et al.
Fanny Vaillant et al.
The pericardium plays an important role in mechanical interactions between the right (RV) and left (LV) ventricles, referred to as ventricular interdependence. However, the exact mechanisms of its supportive role remain unknown. The present...
Divergent selection for basal metabolic rate in mice affects the abundance of UCP1 protein: implications for translational studies [0.03%]
对小鼠基础代谢率进行发散选择会影响UCP1蛋白的丰度：对转化研究的影响
Paweł Brzęk,Piotr Selewestruk,Julita Sadowska et al.
Paweł Brzęk et al.
Low basal metabolic rate (BMR) is a risk factor for obesity, whereas elevation of non-shivering thermogenesis (NST) is a promising means to combat obesity. Because heat generated by NST covers thermogenic needs not fulfilled by BMR, one can...
Computational modelling of cardiac control following myocardial infarction using an in silico patient cohort [0.03%]
利用模拟患者队列对心肌梗死后心脏控制进行计算建模
Michelle M Gee,Abraham M Lenhoff,James S Schwaber et al.
Michelle M Gee et al.
Loss of cardiac physiological function following myocardial infarction (MI) is accompanied by neural adaptations in the baroreflex that are compensatory in the short term, but then become associated with long-term disease progression. One m...
Changes in the cortical GABAergic inhibitory system with ageing and ageing-related neurodegenerative diseases [0.03%]
皮质GABA能抑制系统衰老及与衰老相关神经退行性疾病中的变化趋势研究进展
Wolfgang Taube,Benedikt Lauber
Wolfgang Taube
The human cortical inhibitory system is known to play a vital role for normal brain development, function, and plasticity. GABA is the most prominent inhibitory neurotransmitter in the CNS and is a key regulator not only for motor control a...
Medial hypothalamic MC3R signalling regulates energy rheostasis in adult mice [0.03%]
中脑室旁核MC3受体信号调节小鼠能量稳态
Ingrid Camila Possa-Paranhos,Jared Butts,Emma Pyszka et al.
Ingrid Camila Possa-Paranhos et al.
Although mammals resist both acute weight loss and weight gain, the neural circuitry mediating bi-directional defense against weight change is incompletely understood. Global constitutive deletion of the melanocortin-3-receptor (MC3R) impai...