A proline-tyrosine motif, endocytosis and low salt - how to link protein functions to organ physiology [0.03%]
脯氨酸-酪氨酸基序、内吞作用及低盐条件——如何将蛋白质功能与器官生理学联系起来
Christoph Fahlke
Christoph Fahlke
Jun-activated SOCS1 enhances ubiquitination and degradation of CCAAT/enhancer-binding protein β to ameliorate cerebral ischaemia/reperfusion injury [0.03%]
-Jun活化的SOCS1通过促进C/EBPβ的泛素化降解从而改善脑缺血再灌注损伤
Chuan He,Tie Wang,Yanwu Han et al.
Chuan He et al.
This study investigates the molecular mechanisms behind ischaemia/reperfusion (I/R) injury in the brain, focusing on neuronal apoptosis. It scrutinizes the role of the Jun proto-oncogene in apoptosis, involvement of SOCS1 in neural precurso...
Role of the peripheral chemoreceptors in cardiovascular and metabolic control in type 2 diabetes [0.03%]
Ⅱ型糖尿病时外周化学感受器在心血管和代谢调控中的作用
Jacqueline K Limberg,Elizabeth P Ott,Aubrey M Pipkins et al.
Jacqueline K Limberg et al.
Preclinical work supports a role for the peripheral chemoreceptors in the progression of cardiovascular and metabolic pathologies. In the present study, we examined peripheral chemosensitivity in adults with type 2 diabetes (T2D) and the co...
Differential effect of lead and cadmium on mitochondrial function and NLRP3 inflammasome activation in human trophoblast [0.03%]
铅和镉对人滋养细胞线粒体功能及NLRP3炎性小体激活的差异效应
Yifeng Dai,Xijin Xu,Xia Huo et al.
Yifeng Dai et al.
Heavy metals disrupt mitochondrial function and activate the NOD-like receptor pyrin-containing 3 (NLRP3) inflammasome. We investigated the effect of lead (Pb)/cadmium (Cd) on mitochondrial function and NLRP3 inflammasome activation in huma...
Inducible deletion of endothelial cell Efnb2 delays capillary regeneration and attenuates myofibre reinnervation following myotoxin injury in mice [0.03%]
小鼠内皮细胞Efnb2的可诱导删除延迟了肌毒素损伤后的毛细血管再生和肌纤维再神经生成
Aaron B Morton,Nicole L Jacobsen,Alexandra R Diller et al.
Aaron B Morton et al.
Acute injury of skeletal muscle disrupts myofibres, microvessels and motor innervation. Myofibre regeneration is well characterized, however its relationship with the regeneration of microvessels and motor nerves is undefined. Endothelial c...
Loss of the alpha subunit distal furin cleavage site blunts ENaC activation following Na+ restriction [0.03%]
远端furin切割位点丢失导致α亚单位介导的低钠盐摄入反应减弱
Andrew J Nickerson,Shaohu Sheng,Natalie A Cox et al.
Andrew J Nickerson et al.
Epithelial Na+ channels (ENaCs) are activated by proteolysis of the α and γ subunits at specific sites flanking embedded inhibitory tracts. To examine the role of α subunit proteolysis in channel activation in vivo, we generated mice lac...
Amanda Groenewald,Liam Zhang,Amelia S Power
Amanda Groenewald
Madness or progress? The dilemma of standardizing exercise physiology thresholds [0.03%]
疯狂还是进步？生理学锻炼阈值标准化的困境
Billy Sperlich,Thomas Gronwald
Billy Sperlich