An age-associated decline in the role of the sarcoplasmic reticulum and associated calcium-handling proteins sets the pace for sinoatrial node function [0.03%]
肌浆网及其相关钙处理蛋白的作用随年龄增长而下降，决定了窦房结功能的节奏
Sandra A Jones,Fiona S Godbeer,Matthew K Lancaster
Sandra A Jones
With advancing age, the intrinsic function of the sinoatrial node (SAN) declines, as a result of structural changes and changes in electrical regulation within the constitutive cells of the nodal tissue. This study examined changes to prote...
Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities [0.03%]
缺氧和高碳酸血症引发重叠但又有区别的骨骼肌毒性反应
Joseph Balnis,Ariel Jaitovich
Joseph Balnis
Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary diseases. Hypoxaemia and hypercapnia, which are central hallmarks of respiratory failure, represent critical cellular signals regulati...
Translational studies of chronic supplementation with a mitochondria-targeted antioxidant to improve physical function with ageing [0.03%]
线粒体靶向抗氧化剂改善老年人身体功能的转化研究
Kevin O Murray,Rachel A Gioscia-Ryan,Jaime N Justice et al.
Kevin O Murray et al.
Declines in physical function with advancing age increase the risk of functional limitations and chronic disease. Excess mitochondrial reactive oxygen species (mitoROS)-related oxidative stress is linked to physical dysfunction with ageing,...
6-Methylsulfinylhexyl isothiocyanate activates carbonic anhydrase-dependent HCO3 -/H+/Na+/Ca2+ transport via SLC4As-NHE-NCX-PMCA axis in odontoblasts [0.03%]
6-甲基亚砜己基异硫氰酸酯通过SLC4A-NHE-NCX-PMCA轴激活成牙本质细胞中的碳酸酐酶依赖性HCO3 -/H+/Na +/Ca2 +转运
Yoshiaki Furusawa,Maki Kimura,Isao Okunishi et al.
Yoshiaki Furusawa et al.
Ca2+-permeable transient receptor potential channels, which play an important role in the developmental/reactionary dentinogenesis by odontoblasts, are sensitive to wasabi sulfinyls. We investigated the effects of the wasabi sulfinyls 6-met...
Circular RNAs: Unlocking new avenues in cardiometabolic disease management [0.03%]
循环RNA在心血管代谢性疾病的治疗中的新作用
Kimberley M Mellor,Thomas D Donelly,Gerald L M Naepi et al.
Kimberley M Mellor et al.
Cardiometabolic diseases refer to a group of interrelated conditions that affect both the cardiovascular system and metabolic processes. These conditions represent a significant global health burden and often share common risk factors such ...
Intercalated disk structure, tissue heterogeneity and ion channel distribution modulate conduction and local calcium influx [0.03%]
闰盘结构、组织异质性和离子通道分布调节传导和局部钙离子内流
Nicolae Moise,Heather L Struckman,James W Smyth et al.
Nicolae Moise et al.
The intercalated disk (ID) is the specialized cellular structure that connects cardiomyocytes. Electrogenic proteins are known to be preferentially located at the ID, such as the voltage-gated sodium channel (NaV1.5), inward-rectifying pota...
Intramuscular neutrophil-derived immunometabolic niches locally boost insulin-responsive GLUT4 translocation after muscle contraction [0.03%]
肌肉收缩后肌内中性粒细胞源免疫代谢生态位局部促进胰岛素反应型葡萄糖转运蛋白4转位
Weijian Chen,Makoto Kanzaki
Weijian Chen
Exercise is well known to enhance insulin sensitivity in skeletal muscle, yet the underlying mechanisms remain incompletely understood. We have previously shown that neutrophil recruitment contributes to contraction-induced GLUT4 translocat...
Cortical responses to balance perturbations persist without active postural control [0.03%]
在没有主动姿势控制的情况下，平衡扰动的大脑皮层反应仍然存在
Daphne N R Jansen,Lucas Mensink,Matto Leeuwis et al.
Daphne N R Jansen et al.
Standing balance relies on rapid reflexes as well as longer-latency subcortical and cortical processes to generate corrective responses to postural disturbances. EEG studies consistently identify two perturbation-evoked markers of cortical ...
Females exhibit greater cardiac volume reductions with expiratory muscle loading during submaximal exercise compared to males [0.03%]
与男性相比，女性在亚极量运动时呼气肌负荷下心脏容积减少更明显
Sarah A Angus,Michelle Ottlik,Connor J Doherty et al.
Sarah A Angus et al.
Intrathoracic pressure (ITP) modulates venous return, ventricular filling and ejection throughout the respiratory cycle, and its fluctuations are accentuated during exercise. We sought to determine whether ITP manipulation during submaximal...
Update on cellular expression and function of ANO1 channels in urethral smooth muscle [0.03%]
尿道平滑肌中ANO1通道的细胞表达和功能的新进展
Bernard T Drumm,Neha Gupta
Bernard T Drumm
Urinary continence is maintained by the cooperation of smooth and striated muscles where urethral smooth muscle cell (USMC) contractions contribute to resting urethral tone during bladder filling, whereas striated muscle contracts in respon...