Diving into the unknown: Evidence of enhanced skeletal muscle lactate efflux potential and blood-muscle exchange in competitive breath-hold divers [0.03%]
深不可测：竞技屏息潜水者骨骼肌乳酸外流潜能和血液肌肉交换的证据增强
Antonis Elia,Matthew Lees,John O&#x;Hara et al.
Antonis Elia et al.
The characterization of skeletal muscle phenotypes in diving populations remains one of the least explored domains of breath-hold physiology, representing a critical gap in our understanding of how skeletal muscle adapts to the unique deman...
Beat-to-beat variability of ventricular repolarization reveals sex-specific instability and proarrhythmic risk [0.03%]
心室复极逐搏变异度揭示性别特异的不稳定性及致律失常风险
Daisuke Sato,Lorenzo Santini,Raffaele Coppini et al.
Daisuke Sato et al.
Beat-to-beat QT interval variability (QTV) is a well-established marker of increased vulnerability to ventricular arrhythmias; however the underlying electrophysiological mechanisms remain poorly understood. In this study, we employed sex-s...
Md Tarikul Islam,Mateus R Amorim,Vsevolod Y Polotsky
Md Tarikul Islam
The melanocortin 4 receptor (MC4R) is a key component of the leptin-melanocortin system. Recent studies have started to expand our understanding of the role of MC4R beyond energy balance and sexual behaviour, exploring its potential influen...
The influence of haemoglobin-O2 affinity on aerobic capacity in hypoxia in high-altitude deer mice (Peromyscus maniculatus) [0.03%]
高海拔小鹿鼠血红蛋白-O2亲和力对低氧条件下有氧能力的影响
Kayla M Garvey,Graham R Scott
Kayla M Garvey
High-altitude hypoxia constrains tissue O2 supply, but several high-altitude populations have evolved adaptations to overcome this challenge. Evolved increases in haemoglobin-O2 (Hb-O2) affinity are pervasive across high-altitude taxa, but ...
SARS-CoV-2 targets mitochondria, exacerbating COVID-19 pneumonia [0.03%]
SARS-CoV-2感染损害线粒体功能加重新冠肺炎肺炎病理
Danchen Wu,Asish Dasgupta,Jaskaran Singh Hora et al.
Danchen Wu et al.
Mitochondrial damage is a conserved feature of coronavirus infection, occurring with human (SARS-CoV-2, HCoV-OC43) and murine (MHV-1) coronaviruses. Coronaviruses damage mitochondria in airway epithelial cells (AEC), pulmonary artery smooth...
Machine-learning classification of motor unit types in the adult mouse [0.03%]
基于机器学习的成年小鼠运动神经元类型的分类法
María de Lourdes Martínez-Silva,Reuben M Ahorklo,Emily J Reedich et al.
María de Lourdes Martínez-Silva et al.
Motor unit diversity arises from differences in the contractile properties of muscle fibres and the intrinsic electrical properties of their motoneurons. In mice, however, this relationship has not been quantitatively defined, and conventio...
Angiotensin-converting enzyme 2 enhances megalin-mediated albumin endocytosis in proximal tubule cells by restraining Angiotensin II/AT1R [0.03%]
血管紧张素转换酶2通过抑制血管紧张素II/AT1R增强近端肾小管细胞白蛋白内吞作用
Helena R Peixoto,Rodrigo P Silva-Aguiar,Douglas E Teixeira et al.
Helena R Peixoto et al.
Proximal tubule epithelial cell (PTEC) albumin transport efficiently prevents albuminuria under physiological conditions. This process occurs through a receptor-mediated endocytosis, being megalin, cubilin and amnionless the receptor comple...
Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1 [0.03%]
IQGAP1介导钠离子通道Nav1.7和Nav1.8的转位与激活
Xuming Zhang,Pabitra Hriday Patra,Jinquan Yang
Xuming Zhang
The voltage-gated Nav1.7 and Nav1.8 channels are essential to transmit acute and chronic pain. Increased trafficking of Nav1.7 and Na1.8 channels to the membrane of sensory neurons is a critical mechanism of pain sensitization. However the ...
Maximal exercise at high altitude does not exacerbate inflammation in the human brain [0.03%]
高强度高空运动不会加剧人体大脑炎症反应
Hannah G Caldwell,Travis D Gibbons,Connor A Howe et al.
Hannah G Caldwell et al.
How neuroinflammation is altered at high altitude (HA) is equivocal, and it is unclear whether and how exercise alters this inflammatory response. We tested the hypothesis that maximal exercise at HA exacerbates the neuroinflammatory respon...
Cellular mechanisms of radiation-induced myocyte dysfunction: effects on calcium handling, ion channel regulation and mitochondrial energetics [0.03%]
辐射诱导心肌细胞功能障碍的细胞机制：对钙离子处理、离子通道调节和线粒体能量代谢的影响
Hannah M Zukowski,Colleen E Clancy
Hannah M Zukowski
Ionizing radiation induces a range of cellular responses in cardiomyocytes that vary with the dose, duration of exposure and metabolic state. Although historically attributed to microvascular injury and fibrosis, radiation-induced cardiac d...