Age-related decline in NCKX4-mediated calcium clearance accelerates aortic remodelling and drives early vascular ageing [0.03%]
Livia Rodrigues Costa
Livia Rodrigues Costa
Advancing aortic stenosis assessment: Validation of fluid-structure interaction models against 4D flow MRI data [0.03%]
Alberto Zingaro,Irmantas Burba,David Oks et al.
Alberto Zingaro et al.
Systematic in vivo validations of computational models of the aortic valve (AV) remain scarce, despite successful validation against in vitro data. Utilizing a combination of computed tomography and 4D flow magnetic resonance imaging data, ...
Distinct effects of fibromyalgia pain, depression and anxiety on perception of affective touch and pain [0.03%]
Benedetta Albinni,Marisa Zimmerman,Vincent Alasha et al.
Benedetta Albinni et al.
Gentle stroking that activates C-tactile afferents is typically pleasant, calming and pain relieving. Deep pressure touch frequently elicits similar affective responses. However touch is often less pleasant for individuals with chronic pain...
Maternal nutrition as a key determinant of placental and developing blood-brain barrier xenobiotic protective functions [0.03%]
Kristin L Connor,Nycolle I S Souza,Bruno G Anjos et al.
Kristin L Connor et al.
The placenta and the developing blood-brain barrier (BBB) function as two complementary fetal protective interfaces ensuring nutrient delivery at the same time as limiting fetal brain xenobiotic overexposure. In this review, we integrate ev...
A high-fat, high-sugar diet impairs maternal metabolism throughout pregnancy and lactation in mice [0.03%]
Stephanie E O&#x;Hara,Kelly M Gembus,Georgia S Clarke et al.
Stephanie E O&#x;Hara et al.
Prenatal exposure to maternal overweight and elevated glucose increases risk of cardiometabolic disease in offspring. Preclinical models such as the high-fat, high-sugar (HFHS) fed mouse allow mechanistic studies and testing of intervention...
Ro5-4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62-Keap1-Nrf2 axis [0.03%]
Daphne A Diloretto,Phung N Thai,Gabriela Grigorean et al.
Daphne A Diloretto et al.
The 18-kDa mitochondrial translocator protein (TSPO) has been shown to modulate mitochondrial function and the cardiac response to pressure overload. We have previously shown that conditional knockout of TSPO limited the development of hear...
Exercise training induces mitochondrial biogenesis, while high-fat diet increases the ability of mitochondria to use long and short-chain fatty acids [0.03%]
Jessica L Dowling,Rachel M Handy,Nicole M Notaro et al.
Jessica L Dowling et al.
Short-chain fatty acids (SCFAs), derived from peroxisomal metabolism and the gut microbiota, have been proposed as key substrates to support mitochondrial oxidative phosphorylation (OXPHOS) in extrahepatic tissues such as skeletal muscle. H...
Transfer of paracetamol across the placenta and fetal blood-brain barriers and its safety for use in pregnancy [0.03%]
Yifan Huang,Liam Koehn
Yifan Huang
Paracetamol (acetaminophen) is the most widely used analgesic and antipyretic during pregnancy and has long been considered safe at recommended doses by national health authorities. However, recent preclinical and epidemiological studies ha...
Sex-specific metabolic responses to glucagon receptor agonism and modulation of the FGF21-glucagon axis in female mice [0.03%]
Christoffer Merrild,Valdemar Brimnes Ingemann Johansen,Christoffer Clemmensen et al.
Christoffer Merrild et al.
Glucagon receptor agonism, particularly when combined with incretin analogues, is currently being explored as a treatment for obesity to improve cardiometabolic health, given glucagon's key role in regulating energy homoeostasis. However, m...
Dmitry Fedorov,Fabien Campillo,Mathieu Desroches et al.
Dmitry Fedorov et al.
The lateral habenula (LHb) is a small brain structure specialized in encoding aversive signals. Elevated bursting in the LHb has been linked to depressive-like behaviours in animal models. Bursting is a complex dynamic process that has been...