Profound neuronal differences during exercise-induced hypoalgesia between athletes and non-athletes revealed by functional near-infrared spectroscopy [0.03%]
功能性近红外光谱技术用于研究运动员和非运动员锻炼诱导镇痛的神经机制差异
Maria Geisler,Marco Herbsleb,Feliberto de la Cruz et al.
Maria Geisler et al.
Regular physical activity is an important treatment component for chronic pain. To unravel the neuronal influence of exercise on pain, we investigated the neuronal changes during exercise-induced hypoalgesia in endurance athletes and contro...
Zeynep Elif Yesilyurt-Dirican,Ce Qi,Uchenna Okpechi et al.
Zeynep Elif Yesilyurt-Dirican et al.
Mammalian ageing is defined as a gradual loss of the capacity to maintain tissue homeostasis or to repair tissues after injury or stress. Cellular senescence is induced by various cellular stressors, and there is accumulation of senescent c...
A primary cell-based fluidic co-culture model to investigate drug transport across the human placenta [0.03%]
一种基于原代细胞的流体共培养模型 用于研究药物通过人体胎盘的转运
Barbara Fuenzalida,Nadja Koechli,Edgar Ontsouka et al.
Barbara Fuenzalida et al.
Although women often need to take medication during pregnancy, reliable human-based models mimicking the maternal-fetal interface and allowing predictions on drug transport across the human placenta are scarce. In this study, we developed a...
Chai-Ann Ng
Chai-Ann Ng
Emily Shorter,Oscar Horwath,Sabrina Tzivia Barsky et al.
Emily Shorter et al.
Planned and progressive exercise, that is, exercise training, is essential for promoting skeletal muscle adaptation and improvements in athletic performance. However when the training demands exceed the ability to recover, it may lead to a ...
A computational model for retinal haemodynamics under gravitational and postural variations [0.03%]
考虑重力和体位变化的视网膜血液循环计算模型
Michele Nigro,Andrea Montanino,Eduardo Soudah
Michele Nigro
Spaceflight-associated neuro-ocular syndrome presents a significant risk during long-duration spaceflight, yet the retinal mechanisms underlying these visual changes remain poorly characterized. We developed a physiologically detailed lumpe...
An age-associated decline in the role of the sarcoplasmic reticulum and associated calcium-handling proteins sets the pace for sinoatrial node function [0.03%]
肌浆网及其相关钙处理蛋白的作用随年龄增长而下降，决定了窦房结功能的节奏
Sandra A Jones,Fiona S Godbeer,Matthew K Lancaster
Sandra A Jones
With advancing age, the intrinsic function of the sinoatrial node (SAN) declines, as a result of structural changes and changes in electrical regulation within the constitutive cells of the nodal tissue. This study examined changes to prote...
Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities [0.03%]
缺氧和高碳酸血症引发重叠但又有区别的骨骼肌毒性反应
Joseph Balnis,Ariel Jaitovich
Joseph Balnis
Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary diseases. Hypoxaemia and hypercapnia, which are central hallmarks of respiratory failure, represent critical cellular signals regulati...
Translational studies of chronic supplementation with a mitochondria-targeted antioxidant to improve physical function with ageing [0.03%]
线粒体靶向抗氧化剂改善老年人身体功能的转化研究
Kevin O Murray,Rachel A Gioscia-Ryan,Jaime N Justice et al.
Kevin O Murray et al.
Declines in physical function with advancing age increase the risk of functional limitations and chronic disease. Excess mitochondrial reactive oxygen species (mitoROS)-related oxidative stress is linked to physical dysfunction with ageing,...
6-Methylsulfinylhexyl isothiocyanate activates carbonic anhydrase-dependent HCO3 -/H+/Na+/Ca2+ transport via SLC4As-NHE-NCX-PMCA axis in odontoblasts [0.03%]
6-甲基亚砜己基异硫氰酸酯通过SLC4A-NHE-NCX-PMCA轴激活成牙本质细胞中的碳酸酐酶依赖性HCO3 -/H+/Na +/Ca2 +转运
Yoshiaki Furusawa,Maki Kimura,Isao Okunishi et al.
Yoshiaki Furusawa et al.
Ca2+-permeable transient receptor potential channels, which play an important role in the developmental/reactionary dentinogenesis by odontoblasts, are sensitive to wasabi sulfinyls. We investigated the effects of the wasabi sulfinyls 6-met...