Activating Group II Metabotropic Glutamate Receptors in the Basolateral Amygdala Inhibits Increases in Reward Seeking Triggered by Discriminative Stimuli in Rats [0.03%]
大鼠 basolateral 干细胞中Ⅱ组代谢型谷氨酸受体的激活可抑制条件线索诱发的过度觅奖行为
Mandy Rita LeCocq,Amélie Mainville-Berthiaume,Isabel Laplante et al.
Mandy Rita LeCocq et al.
Background: Reward-associated cues guide reward-seeking behaviours. These cues include conditioned stimuli (CSs), which occur following seeking actions and predict reward delivery, and discriminative stimuli (DSs), which ...
Safety and Efficacy with Esketamine in Treatment-Resistant Depression: Long-Term Extension Study [0.03%]
氯胺酮派生成分艾司氯胺酮治疗难治性抑郁症的长期疗效及安全性研究
Naim Zaki,Li Nancy Chen,Rosanne Lane et al.
Naim Zaki et al.
Importance: The rates of relapse and suicide risk are higher in treatment-resistant depression (TRD) versus non-treatment-resistant major depressive disorder. Even among patients with TRD who initially respond, the majori...
Molecular targets of vortioxetine mediating glioblastoma suppression revealed by gene and protein network analyses and molecular docking simulations [0.03%]
基因和蛋白质网络分析及分子对接模拟揭示伏硫西定抑制胶质母细胞瘤的分子靶点
Chuanjun Zhuo,Chao Li,Qiuyu Zhang et al.
Chuanjun Zhuo et al.
Background: Vortioxetine is a serotonin reuptake inhibitor and serotonin receptor modulator used for the treatment of major depressive disorder, but recent studies have also reported anticancer effects in models of gliobl...
Cognitive improvement effects of PF-04957325, a phosphodiesterase-8 inhibitor, in mouse models of Alzheimer's disease via modulating neuroinflammation [0.03%]
一种名为PF-04957325的磷酸二酯酶-8抑制剂通过调节神经炎症改善阿尔茨海默病小鼠模型的认知功能的效果研究
Tian-Yang Guo,Meng Zhang,Yu-Li Lv et al.
Tian-Yang Guo et al.
Background: Alzheimer's disease (AD) is a neurodegenerative disease characterized by memory deficit and has emerged as a growing global health concern. Phosphodiesterase-8 (PDE8) is a cAMP-specific hydrolase and its corre...
Cigarette Smoking is Associated with Levels of the Serotonin Transporter in the Brain: A [11C]DASB PET Study [0.03%]
吸烟与脑内血清素转运蛋白水平相关：一项[11C]DASB正电子发射断层扫描研究
Paul Faulkner,Gitte M Knudsen,Vibe G Frokjaer et al.
Paul Faulkner et al.
Background: Preclinical work suggests that chronic nicotine/tobacco use is associated with reductions in serotonin within the hippocampus, yet no research has yet shown an association of smoking behaviours and alterations...
Moving towards precision and personalized treatment strategies in psychiatry [0.03%]
向精准和个性化治疗策略迈进—— Psychiatry 第一期主题论文集序言
Stefano Comai,Mirko Manchia,Marta Bosia et al.
Stefano Comai et al.
Precision psychiatry aims to improve routine clinical practice by integrating biological, clinical, and environmental data. Many studies have been performed in different areas of research on major depressive disorder, bipolar disorder, and ...
Distinct Effects of Psychiatric Disorder Diagnoses and Severe Emotional Dysregulation on Matrix Metalloproteinase-9, Proinflammatory Cytokines, and Inhibitory Control Function in Adolescents with Attention Deficit Hyperactivity Disorder or First-Episode Major Affective Disorders [0.03%]
注意缺陷多动障碍或首次发作情绪紊乱障碍青少年中精神疾病诊断和重度情感失调节对基质金属蛋白酶-9、促炎症细胞因子及抑制控制功能的独立影响
Ju-Wei Hsu,Li-Chi Chen,Ya-Mei Bai et al.
Ju-Wei Hsu et al.
Background: Severe emotional dysregulation (SED) may represent an endophenotype of attention deficit hyperactivity disorder (ADHD) and major affective disorders. However, the specific effects of SED and related psychiatri...
Addressing blinding in classic psychedelic studies with innovative active placebos [0.03%]
用创新性活性安慰剂解决经典致幻剂研究中的盲法问题
Jacob S Aday,Otto Simonsson,Emmanuelle A D Schindler et al.
Jacob S Aday et al.
Rationale: Classic psychedelics show promise as a treatment for various neuropsychiatric disorders. However, weak blinding integrity in trials has been argued to limit the capacity to definitively attribute therapeutic ef...
D Behzad,S Zhao,R Besa et al.
D Behzad et al.
Importance: Driving under the influence of cannabis increases the risk of motor vehicle collisions. In some jurisdictions, deterrence rests on the ability to detect delta-9-tetrahydrocannabinol (THC) in blood. Recent evid...
Association of Relapse With All-Cause Mortality in Adult Patients With Stable Schizophrenia [0.03%]
复发与稳定期成人精神分裂症患者的全因死亡率之间的关联性研究
Christoph U Correll,Brahim K Bookhart,Carmela Benson et al.
Christoph U Correll et al.
Background: Schizophrenia shortens the average lifespan by an estimated 15 years. This retrospective study evaluated whether relapse independently increases all-cause mortality risk in patients with stable schizophrenia. ...