Neurotoxic biomarkers of ethanol exposure: from adolescent vulnerability to adult voluntary intake in rats of both sexes [0.03%]
乙醇暴露的神经毒性生物标志物：从青春期易感性到成年期自愿摄入（雌雄 rats均适用）
Carles Colom-Rocha,M Julia García-Fuster
Carles Colom-Rocha
Background: Ethanol use is frequently initiated during adolescence, a vulnerable developmental period with a great deal of neuro-remodeling, specially affecting hippocampal integrity, and with a unique sensitivity to drug...
Stress-Induced Altered Expression of Hippocampal Nuclear and Mitochondrial Encoded Genes in Rats and Cross-Species Genetic Associations Reveal Molecular Links to Depression [0.03%]
应激诱导的大鼠海马核基因和线粒体基因表达的改变及跨物种遗传关联揭示了与抑郁症的分子联系
Ellie Hulwi,Qingzhong Wang,Aleena Francis et al.
Ellie Hulwi et al.
Background: Mitochondria play a pivotal role in energy production, and their dysfunction not only hampers cells' ability to meet energy requirements but also contributes to the impairment of neural plasticity, a critical ...
Antidepressant Efficacy of Ketamine Plus Naltrexone for Major Depression Comorbid with Alcohol Use Disorder: A Randomized Controlled Trial [0.03%]
氯胺酮联用纳曲酮治疗伴发酒精使用障碍的抑郁症随机对照试验
Gihyun Yoon,Brian Pittman,Elizabeth Ralevski et al.
Gihyun Yoon et al.
Importance: The comorbidity of major depressive disorder (MDD) and alcohol use disorder (AUD) is often treated inadequately. This study evaluated the impact of adding the opioid receptor blocker, naltrexone, to the NMDA g...
Distinct Neural Activation Patterns in Executive Functions of Schizophrenia Patients with Predominant Positive and Negative Symptoms: An fNIRS Study [0.03%]
阳性及阴性症状为主的精分患者执行功能障碍激活模式的功能近红外光谱研究
Yinqing Xu,Xiaoning Huo,Xiaolong Yang et al.
Yinqing Xu et al.
Objective: To investigate the differences in executive functions, specifically cognitive flexibility and inhibitory control, between schizophrenia (SCH) patients with predominantly positive symptoms (PSD) and those with p...
Trajectory of Efficacy and Safety Across Ulotaront Dose Levels in Schizophrenia: A Systematic Review and Dose-Response Meta-Analysis [0.03%]
乌洛塔若单抗不同剂量治疗精神分裂症疗效及安全性轨迹的系统性综述和剂量反应meta分析
Yo-Chia Hsu,Tzu-Yen Hung,Yang-Chieh Brian Chen et al.
Yo-Chia Hsu et al.
Background: Ulotaront is an experimental antipsychotic for schizophrenia, but its optimal dose is unclear. This study aimed to evaluate dose-response relationships for efficacy and safety in people with schizophrenia. ...
Five-factor personality traits in patients with schizophrenia and bipolar disorder: A systematic review and meta-analysis [0.03%]
精神分裂症和双相障碍患者的五大人格特质：系统评价和荟萃分析
Mayuka Hashimoto,Kazutaka Ohi,Daisuke Fujikane et al.
Mayuka Hashimoto et al.
Background: Personality traits play crucial roles in the onset, manifestation, and course of schizophrenia and bipolar disorder (BD). Previous meta-analyses focusing on NEO personality traits in patients with schizophreni...
Intranasal administration of KCNN2 blocking peptide improves deficits in cognitive flexibility in mouse model of Fetal Alcohol Spectrum Disorders [0.03%]
鼻内给药KCNN2阻断肽可改善胎儿酒精谱系障碍小鼠模型的认知灵活性缺陷
Shahid Mohammad,Li Wang,Masaaki Torii et al.
Shahid Mohammad et al.
Background: Fetal Alcohol Spectrum Disorders (FASD) show a myriad of cognitive and neurological deficits, with the prevalence estimated to be 1-5 % in children. To date, there are no effective treatments for these deficit...
Correction to: From theory to therapy: unlocking the potential of muscarinic receptor activation in schizophrenia with the dual M1/M4 muscarinic receptor agonist xanomeline and trospium chloride and insights from clinical trials [0.03%]
correction to：“从理论到疗法：通过双M₁/M₄胆碱受体激动剂盐酸他罗西明和氯苯拉敏的激活释放精神分裂症治疗潜能并从临床试验中获得启示”
Cariprazine & Clozapine: A systematic review of a promising antipsychotic combination for treatment-resistant schizophrenia [0.03%]
卡利拉嗪与氯氮平：治疗难治性精神分裂症的潜在抗精神病药物组合的系统评价研究
Sofia Pappa,Réka Csehi,Ellice Caldwell-Dunn et al.
Sofia Pappa et al.
Background: Treatment-resistant schizophrenia (TRS) affects over half of individuals with schizophrenia. Clozapine is the only FDA-approved treatment but often provides limited relief. Augmenting clozapine with cariprazin...