Neuropathic Pain impairs Sleep Architecture, NREM sleep and Reticular Thalamic Neuronal activity [0.03%]
神经痛损害睡眠构架，非快速眼动睡眠和网状丘脑神经元的活动性
Martha López-Canul,Anahita Oveisi,Qianzi He et al.
Martha López-Canul et al.
Background: Neuropathic pain (NP) is a chronic and debilitating condition frequently comorbid with insomnia. However, the alterations in sleep architecture under NP conditions and the mechanisms underlying both pain and s...
Examination of the relationship between D-amino acid profiles and cognitive function in individuals with mild cognitive impairment: A machine learning approach [0.03%]
D-氨基酸谱与轻度认知障碍个体认知功能的关系研究：机器学习方法
Sou Sugiki,Shigeki Tsuchiya,Ren Kimura et al.
Sou Sugiki et al.
Background: The global prevalence of dementia is significantly increasing. Early detection and prevention strategies, particularly for mild cognitive impairment (MCI), are crucial but currently hindered by the lack of est...
From Theory to Therapy: Unlocking the Potential of Muscarinic Receptor Activation in Schizophrenia With the Dual M1/M4 Muscarinic Receptor Agonist Xanomeline and Trospium Chloride and Insights From Clinical Trials [0.03%]
从理论到疗法：使用双重M1 / M4毒蕈碱受体激动剂Xanomeline和氯化trospium解锁精神分裂症中毒蕈碱受体激活的潜能及临床试验中的启示
Jonathan M Meyer,Ken Kramer,Scott Vuocolo et al.
Jonathan M Meyer et al.
Since the 1950s, understanding of antipsychotic activity in schizophrenia has been largely grounded in the dopamine hypothesis. Most antipsychotics approved for schizophrenia interact with D2 dopamine receptors as an important part of their...
Altered Proteomics in Brain Extracellular Vesicles from Depressed Individuals Who Died by Suicide Implicates Synaptic Processes [0.03%]
来自自杀抑郁症患者的改变脑胞外囊泡蛋白质组学涉及到突触过程
Pascal Ibrahim,Haruka Mitsuhashi,Lorne Taylor et al.
Pascal Ibrahim et al.
Background: Major Depressive Disorder (MDD) is a common and debilitating disorder whose molecular neurobiology remains unclear. Extracellular vesicles (EVs) are small vesicles that are released by cells and are involved i...
Synergistic effects of memantine and alpha7 nicotinic acetylcholine receptor agonist PHA-543613 to improve memory of aged rats [0.03%]
改善老年大鼠记忆的多奈哌齐与烟碱型乙酰胆碱受体激动剂PHA-543613联用实验研究
Nóra Bruszt,Zsolt Kristóf Bali,Lili Veronika Nagy et al.
Nóra Bruszt et al.
Background: Combination treatments based on pharmacological interactions at α7 nicotinic acetylcholine receptors (nAChR) are promising therapeutic approaches for neurocognitive disorders. ...
Neurobiological Influences on Event Perception: The Role of Catecholamines [0.03%]
神经生物学对事件认知的影响：儿茶酚胺的作用
Foroogh Ghorbani,Xianzhen Zhou,Veit Roessner et al.
Foroogh Ghorbani et al.
Background: Event segmentation, the cognitive process of parsing continuous experiences into discrete events, plays a fundamental role in how humans perceive and interact with their environment. Guided by Event Segmentati...
Gustavo H Vázquez,Ross J Baldessarini
Gustavo H Vázquez
Background: Depression is a therapeutic challenge with bipolar disorder (BD) patients and remains a major contributor to disability, comorbidity, and premature mortality. Efficacy and safety of antidepressants for this in...
Inhibition of PDE4B ameliorates cognitive defects in the model of alcoholic dementia in 3×Tg-AD mice via PDE4B/cAMP/PKA signaling [0.03%]
PDE4B抑制通过PDE4B/cAMP/PKA信号传导改善3×Tg-AD小鼠酒精痴呆模型的认知缺陷
Rongzhen Sun,Mei Han,Yuanyuan Lin et al.
Rongzhen Sun et al.
Background: Chronic, heavy alcohol use may lead to permanent brain damage, cognitive impairment, and dementia. One of the most serious consequences is alcoholic dementia (AlD). Phosphodiesterase-4 (PDE4) inhibitors have b...
Towards an expanded neurocognitive account of ketamine's rapid antidepressant effects [0.03%]
探讨扩大神经认知学说解释氯胺酮快速抗抑郁作用
Yingliang Dai,Ben J Harrison,Christopher G Davey et al.
Yingliang Dai et al.
Ketamine is an N-methyl-D-aspartate receptor (NMDAR) antagonist that has shown effectiveness as a rapidly acting treatment for depression. Although advances have been made in understanding ketamine's antidepressant pharmacological and molec...