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A Preliminary Study on Transcriptional Regulation of SNP Site C-1888T in the Promoter Region of Human PLUNC Gene and Nasopharyngeal Carcinoma Susceptibility [0.03%] PLUNC基因启动子区单核苷酸多态性位点C-1888T转录调控与鼻咽癌易感性的关系初步研究
Beina Liu,Rong Wang,Ying He Beina Liu
Purpose: The transcriptional regulatory factors binding to the polymorphic site C-1888T in the promoter region of the palate, lung, and nasal epithelium clone (PLUNC) gene were identified to investigate whether the C-1888T polymorphic site ...
Kun Chen,Lei Pu,Yuzuo Hui Kun Chen
Backgrounds: Glioma stands as one of the most formidable brain tumor types, with patient outcomes remaining bleak even in the face of advancements in treatment modalities. FBXW4, a constituent of the F-box and WD repeat d...
Comprehensive Analysis of the Mechanism of Anoikis in Hepatocellular Carcinoma [0.03%] 肝癌中Anoikis机制的综合分析
Dongqian Li,Qian Bao,Shiqi Ren et al. Dongqian Li et al.
Background: Hepatocellular carcinoma (HCC), ranking as the second-leading cause of global mortality among malignancies, poses a substantial burden on public health worldwide. Anoikis, a type of programmed cell death, serv...
Identification and Validation of Cytotoxicity-Related Features to Predict Prognostic and Immunotherapy Response in Patients with Clear Cell Renal Cell Carcinoma [0.03%] 识别和验证细胞毒性相关的特征以预测透明细胞肾细胞癌患者的预后和免疫治疗反应
Junxiao Yu,Bowen Zhao,You Yu Junxiao Yu
Background: Clear cell renal cell carcinoma (ccRCC) is a renal cortical malignancy with a complex pathogenesis. Identifying ideal biomarkers to establish more accurate promising prognostic models is crucial for the surviv...
Investigating the Prognostic and Oncogenic Roles of Membrane-Associated Ring-CH-Type Finger 9 in Colorectal Cancer [0.03%] 膜相关RING指状家族成员9在结直肠癌预后及致癌中的作用研究
Jiayan Zhang,Qinghan Jiao,Zhigang Chen Jiayan Zhang
Backgroundsand Aims. Colorectal cancer (CRC) represents a major global health challenge, necessitating comprehensive investigations into its underlying molecular mechanisms to enhance diagnostic and therapeutic strategies. This study focuse...
Impact of Extracellular Matrix-Related Genes on the Tumor Microenvironment and Prognostic Indicators in Esophageal Cancer: A Comprehensive Analytical Study [0.03%] 基质相关基因对食管癌肿瘤微环境的影响及预后指示物的综合分析研究
Yinghong Wu,Wenjie Hu,Zhihong Jia et al. Yinghong Wu et al.
Esophageal cancer is a major global health challenge with a poor prognosis. Recent studies underscore the extracellular matrix (ECM) role in cancer progression, but the full impact of ECM-related genes on patient outcomes remains unclear. O...
Analysis of Bladder Cancer Staging Prediction Using Deep Residual Neural Network, Radiomics, and RNA-Seq from High-Definition CT Images [0.03%] 基于高分辨率CT影像的深度残差神经网络、影像组学和RNA-seq分析膀胱癌分期预测研究
Yao Zhou,Xingju Zheng,Zhucheng Sun et al. Yao Zhou et al.
Bladder cancer has recently seen an alarming increase in global diagnoses, ascending as a predominant cause of cancer-related mortalities. Given this pressing scenario, there is a burgeoning need to identify effective biomarkers for both th...
Variants in Candidate Genes for Phenotype Heterogeneity in Patients with the 22q11.2 Deletion Syndrome [0.03%] 22q11.2缺失综合征患者表型异质性的候选基因变异
Natalia Nunes,Beatriz Carvalho Nunes,Malú Zamariolli et al. Natalia Nunes et al.
22q11.2 deletion syndrome (22q11.2DS) is a microdeletion syndrome with a broad and heterogeneous phenotype, even though most of the deletions present similar sizes, involving ∼3 Mb of DNA. In a relatively large population of a Brazilian 22...
HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia [0.03%] 慢性淋巴细胞白血病罗马尼亚患者的HLA基因多态性
Maria Tizu,Bogdan Calenic,Mihai Hârza et al. Maria Tizu et al.
Materials and methods: This study included 66 patients with CLL, diagnosed between 2020 and 2022, and 100 healthy controls. HLA class I and class II genes (HLA-A/B/C, HLA-DQA1/DQB1/DPA1/DPB1, and HLA-DRB1/3/4/5) were inve...
Genome-Wide Comprehensive Identification and In Silico Characterization of Lectin Receptor-Like Kinase Gene Family in Barley (Hordeum vulgare L.) [0.03%] barley（Hordeum vulgare L.）中凝集素受体样蛋白激酶基因家族的全基因组鉴定及计算机辅助特征分析
Fee Faysal Ahmed,Farah Sumaiya Dola,Md Shohel Ul Islam et al. Fee Faysal Ahmed et al.
Lectin receptor-like kinases (LecRLKs) are a significant subgroup of the receptor-like kinases (RLKs) protein family. They play crucial roles in plant growth, development, immune responses, signal transduction, and stress tolerance. However...