Csaba Szabo
Csaba Szabo
The academic publishing system needs to include replication of key experiments wherever possible to meet the replication crisis. A major challenge is to incentive validation and provide funding for it. [Figure: see tex...
PPARG directs trophoblast cell fate and establishment of the uterine-placental interface [0.03%]
PPARG指引滋养细胞命运和子宫-胎盘界面的建立
Esteban M Dominguez,Ayelen Moreno-Irusta,Khursheed Iqbal et al.
Esteban M Dominguez et al.
The expansion and differentiation of trophoblast stem (TS) cells are critical for defining fundamental properties of the placenta. Specialized trophoblast cells called extravillous trophoblast (EVT) cells in human and invasive trophoblast c...
What counts as an embryo? : The regulatory status of stem cell-based embryo models in Asia [0.03%]
什么才算是胚胎？：亚洲基于干细胞的合成胚胎监管现状
Tsutomu Sawai,Shu Ishida,Chie Kobayashi et al.
Tsutomu Sawai et al.
This paper examines legal frameworks and ongoing debates concerning research with human stem cell–based embryo models (SCBEMs) in China, Japan, Malaysia, Singapore, South Korea, and Taiwan. Given their great potential for research and thei...
3D chromatin organisation contributes to the regulatory logic in differentiating lymphatic endothelium [0.03%]
三维染色体结构有助于分化淋巴内皮细胞的调控逻辑
Virginia Panara,Hannah Arnold,Marleen Gloger et al.
Virginia Panara et al.
Gene activation and repression is an integral part of embryonic development and tissue formation. Changes in chromatin organisation dictate accessibility to gene regulatory elements, controlling gene expression. Although several molecular r...
Polyunsaturated fatty acid sequestration protects against mitochondrial dysfunction-induced ferroptosis [0.03%]
多不饱和脂肪酸的隔离可防止线粒体功能障碍诱导的铁死亡
Guillermo Puertas-Frías,María José Saucedo-Rodríguez,Kristýna Čunátová et al.
Guillermo Puertas-Frías et al.
Impaired energy production is a hallmark of mitochondrial oxidative phosphorylation (OXPHOS) defects. However, secondary metabolic disturbances also represent an important trigger for pathologies originating from OXPHOS aberrations. Here we...
When expertise became just another opinion : Rebuilding trust through a transparent infrastructure for verified scientific knowledge [0.03%]
当专业知识仅仅成为另一种观点时：通过透明的基础设施重建可验证的科学知识的信任
Marek Marzec
Marek Marzec
Scientific knowledge is advancing faster than ever, yet its authority is increasingly detached from the way information circulates in public debates. This article proposes a transparent, professionally curated repository of validated scient...
Theresa Haitzmann,Niklas B Thompson,Hardik Shah et al.
Theresa Haitzmann et al.
Cancer cells frequently show elevated glucose consumption to support proliferation and survival. This led to the assumption that glycolytic inhibitors could be effective in cancer treatment. However, barriers to clinical implementation rema...
Reimagining reproductive futures : Speculative Design as an Artistic-Public Thought Experiment [0.03%]
重构生育未来：作为艺术公众思想实验的构想型设计
Bridget X Li,Aviad Raz,Jusaku Minari
Bridget X Li