Epigenetic Shifts in MTNR1A, MTNR1B and Fn14 and Their Links to Preeclampsia Risk [0.03%]
与子痫前期风险相关的MTNR1A、MTNR1B和Fn14表观遗传改变及其联系
Sana Kashif Shahid,Syeda Sadia Fatima,Sabah Farhat et al.
Sana Kashif Shahid et al.
Background: Preeclampsia (PE) is a complex pregnancy disorder associated with early placental hypoxia, oxidative stress, and impaired angiogenic signaling. Melatonin and soluble tumor necrosis factor like weak inducer of ...
Hip Bone Marrow Adiposity as a Risk Factor for Alzheimer's Disease: Insights From Mendelian Randomization Analysis [0.03%]
骨髓脂肪含量与阿尔茨海默病风险相关性研究：孟德尔随机化分析的新启示
Wei Shi,Zhenhua Zhu,Minghui Wu et al.
Wei Shi et al.
Background: The bone-brain axis has emerged as a critical framework linking skeletal metabolism to neurodegeneration. Within this axis, bone marrow adipose tissue (BMAT) represents a unique fat depot with distinct endocri...
A Novel Biallelic REL Frameshift Variant p.(Tyr9Ilefs*2) Causing Immunodeficiency-92 With Profound c-Rel Deficiency [0.03%]
导致免疫缺陷病92的新双等位REL移码变异体p.(Tyr9Ilefs*2)引起的重度c-Rel缺乏症
Mohsine-Ali El-Hamri,Zineb Sabky,Nada Benyahya et al.
Mohsine-Ali El-Hamri et al.
Background and aims: Inborn errors of immunity (IEI) refer to a heterogeneous group of monogenic disorders caused by germline variants that disrupt immune function. Among these conditions, immunodeficiency 92 (IMD92), an ...
Identification of PSMA4 as a Therapeutic Target for Atherosclerosis: A Comprehensive Multiomics Mendelian Randomization Analysis [0.03%]
PSMA4作为治疗靶点防治动脉粥样硬化的多组学孟德尔随机化分析研究
Yongchao Yu,Yuan Zhu,Qian Tian et al.
Yongchao Yu et al.
Purpose: Atherosclerosis (AS) is a leading cause of cardiovascular disease, and current treatments often fail to induce plaque regression. This study aims to identify novel, genetically supported therapeutic targets for A...
Genetic Insights Into Hypertension and Breast Cancer Risk in African Women: A Mendelian Randomization and Colocalization Analyses [0.03%]
非洲女性高血压和乳腺癌风险的遗传学见解：孟德尔随机化和共定位分析
Emmanuel Owusu Ansah,Emmanuel Boateng Agyenim,Andrews Danquah et al.
Emmanuel Owusu Ansah et al.
Background: Breast cancer (BC) is a major global health concern. Although observational studies have reported an association between hypertension and BC risk, the causal nature of this relationship remains unclear. ...
Genetic Diversity and Historical Divergence of Malays and Indigenous Populations in Peninsular Malaysia and Northern Borneo [0.03%]
马来半岛和北婆罗洲的马来人和土著人口的遗传多样性及历史分化研究
Woei-Yuh Saw,Chee Wei Yew,Thuhairah Abdul Rahman et al.
Woei-Yuh Saw et al.
Previous studies have highlighted significant genetic structure among Southeast Asian populations, with Northern Borneo natives closely related to Austronesians from Taiwan and the Philippines, and Peninsular Malaysia indigenous populations...
Downregulation of EPAS1 and EGLN1 mRNA Expression Associated With High-Altitude Adaptive Genetic Variants in Sherpa Highlanders [0.03%]
与夏尔巴高原居民的高海拔适应性遗传变异相关的EPAS1和EGLN1mRNA表达下调
Yunden Droma,Fengming Yue,Masao Ota et al.
Yunden Droma et al.
Background and aims: Sherpa highlanders exhibit remarkable tolerance to hypoxia, most likely due to genetic adaptations shaped by natural selection at high altitude. This study examined the roles of endothelial PAS domain...
Mitonuclear Discordance and Gout, Type 2 Diabetes and Chronic Kidney Disease in Aotearoa New Zealand Indigenous Māori and Pacific People [0.03%]
线粒体核DNA不一致与新西兰毛利人和太平洋岛民的痛风、2型糖尿病和慢性肾病的关系
Rachel R Dickerson,Riku Takei,Murray Cadzow et al.
Rachel R Dickerson et al.
Background: Mitochondrial proteins are encoded by both mitochondrial- and nuclear-encoded genes. Because mitochondrial DNA (mtDNA) is maternally inherited, admixed individuals may have different ancestral sources for thei...
Construction of a Prognostic and Diagnostic Gene Signature Based on the Characteristics of Cancer Stem-Like Cells for the Treatment Guidance of Hepatocellular Carcinoma [0.03%]
基于癌症干细胞样细胞特征的肝癌预后和诊断基因标记的构建及临床意义研究
Xiawei Li,Min Wang,Xiang Zhang et al.
Xiawei Li et al.
Background: Hepatocellular carcinoma (HCC) is a highly aggressive cancer with significant intratumoral heterogeneity, likely contributed by the differentiation of cancer stem-like cells (CSCs) into multiple cancer cell li...
The Genetic Basis of Neurological Disorders: Missense and Nonsense Variants in Three Pakistani Families With Syndromic Intellectual Disability [0.03%]
巴基斯坦三个具有综合症性智障的家族中错义和无义变异的遗传基础-神经性疾病遗传学研究
Kenza Javed,Nazif Muhammad,Syeda Iqra Hussain et al.
Kenza Javed et al.
Background: Neurological disorders affect both the central and peripheral nervous systems, exhibiting broad genetic and clinical variability and posing a significant public health concern. These conditions range from comm...