Leonard Leibovici
Leonard Leibovici
An introduction to Network Meta-analyses in clinical microbiology and infectious diseases [0.03%]
临床微生物学和感染病中网络Meta分析介绍
Georgios Seitidis,Ourania Koutsiouroumpa,Roland van Rensburg et al.
Georgios Seitidis et al.
Background: Network Meta-Analysis (NMA) allows synthesizing results from studies comparing all available interventions. It uses direct evidence from studies comparing directly two interventions (say B and C) but also indi...
Estimating the potential economic and health impact of integrated genomic surveillance in a hospital setting [0.03%]
医院综合基因组监测的潜在经济和健康影响评估
Frederik Boetius Hertz,Karen Leth Nielsen,Dmytro Strunin et al.
Frederik Boetius Hertz et al.
Objectives: Integrated genomic surveillance, combining whole genome sequencing (WGS) of bacterial isolates with patient movement data, promises improved detection and prevention of pathogen transmission. However, evidence...
Randomized clinical trial to evaluate the longitudinal HIV-1 reservoir and inflammation in treatment-naïve people starting dolutegravir/lamivudine vs. dolutegravir plus tenofovir alafenamide/emtricitabine [0.03%]
启动多替拉韦/拉米夫定与多替拉韦联合恩曲他滨/泰佛乐治疗的初治患者的HIV-1储藏库和炎症纵向随机对照试验
Abraham Saborido-Alconchel,Ana Serna-Gallego,María Trujillo-Rodriguez et al.
Abraham Saborido-Alconchel et al.
Objective: There is limited evidence on whether dolutegravir/lamivudine (DTG/3TC) reduces the viral reservoir, immune activation, and inflammation as a three-drug regimen. This study aims to clarify possible differences i...
Paulína Belvončíková,Roman Gardlík
Paulína Belvončíková
Background: Recurrent urinary tract infections (rUTIs) are a major clinical burden, increasingly complicated by multidrug-resistant organisms (MDROs) and antibiotic overuse. Growing evidence implicates gut microbiota dysb...
Funding and geographical distribution of clinical trials in infectious diseases [0.03%]
传染病临床试验的资助及地域分布
Hadrien Moffroid,Esmita Charani,Christina Blagojevic et al.
Hadrien Moffroid et al.
Objectives: To map funding flows in infectious disease randomized clinical trials (RCTs) by examining relationships between funding sources and trial locations in high impact journals. ...
Association between COVID-19 vaccine immunogenicity and protection against infection and severe disease in clinically vulnerable patient populations: a systematic review and meta-analysis of observational studies [0.03%]
针对临床易感人群COVID-19疫苗免疫原性与预防感染和重症关联性的系统评价和meta分析
Maria Danysz,Rute Cardoso De Aguiar,Hema Pindolia et al.
Maria Danysz et al.
Background: The use of measured immune responses in informing risk of breakthrough COVID-19 infection and infection outcomes after vaccination against SARS-CoV-2 in clinically vulnerable patients has not been applied clin...
In Vitro Activity and Resistance Mechanisms of Sulbactam/Durlobactam Against Acinetobacter baumannii Clinical Isolates in China (2019-2020) [0.03%]
舒巴坦/杜鲁培坦对我国（2019-2020）分离的鲍曼不动杆菌临床菌株的体外活性及耐药机制研究
Qingye Xu,Xiaochen Liu,Haiyang Liu et al.
Qingye Xu et al.
Objectives: Carbapenem-resistant Acinetobacter baumannii (CRAB) poses a critical threat, with carbapenem-resistance rate exceeding 70% and limited therapeutic options in China. This multicenter study aimed to evaluate in ...
Safety and immunogenicity of adjuvanted respiratory syncytial virus vaccine in high-risk transplant recipients: An Interventional Cohort Study [0.03%]
移植高危受者中呼吸道合胞病毒疫苗（含佐剂）的安全性与免疫原性：干预队列研究
Victoria G Hall,Adrian A Alexander,Faranak Mavandadnejad et al.
Victoria G Hall et al.
Objectives: Allogeneic hematopoietic cell transplant (alloHCT) and lung transplant (LT) recipients are at highest risk for severe respiratory syncytial virus (RSV) disease, even as compared to other immunocompromised grou...
Complex pathways to ceftolozane-tazobactam resistance in clinical Pseudomonas aeruginosa isolates: a genomic epidemiology study [0.03%]
临床产碱杆菌株对头孢他韦-他唑巴坦抗性的复杂获得机制：一项基因组流行病学研究
Hoai-An Nguyen,Anton Y Peleg,Jiangning Song et al.
Hoai-An Nguyen et al.
Objectives: We aimed to conduct a comprehensive genomic analysis of ceftolozane/tazobactam (C/T) resistance mechanisms in Pseudomonas aeruginosa by combining novel institutional data with publicly available sequencing dat...