Drop the MICs: rethinking the routine use of minimum inhibitory concentrations [0.03%]
告别MIC：重新考虑常规使用最小抑菌浓度抗生素的做法
Vincent Fihman,Guilhem Royer,Florence Reibel et al.
Vincent Fihman et al.
Diagnostic accuracy of cerebrospinal fluid gram stain for bacterial meningitis in patients with a suspected central nervous system infection [0.03%]
疑似中枢神经系统感染患者细菌性脑膜炎脑脊液涂片诊断准确性分析
Emiel F van Beek,Sabine E Olie,Steven L Staal;I-PACE study group;Diederik van de Beek et al.
Emiel F van Beek et al.
Objectives: Bacterial meningitis is a life-threatening disease requiring rapid pathogen identification and prompt initiation of treatment. Cerebrospinal fluid (CSF) Gram stain is a widely recommended, rapid diagnostic tes...
Reduced outpatient antibiotic prescribing is not associated with increased incidence of upper respiratory tract infections and complications: a large population-based cohort study [0.03%]
门诊抗生素处方减少与上呼吸道感染及并发症发病率增加无关：一项基于人群的大规模队列研究
Katarina Hedin,Fredrik Oscarson,Thomas Cars et al.
Katarina Hedin et al.
Objectives: Inappropriate antibiotic use contributes to adverse events and resistance development. Implementation of antimicrobial stewardship (AMS) programmes has resulted in marked declines in outpatient antibiotic pres...
Chimeric antigen receptor therapy in infectious diseases: emerging applications with a focus on invasive fungal infections [0.03%]
嵌合抗原受体疗法在传染病中的应用：以侵袭性真菌感染为重点的研究进展
Carme Bracke,Ignacio Grafia,Pedro Puerta-Alcalde
Carme Bracke
Background: Infections remain a major cause of morbidity and mortality among immunocompromised patients, particularly in the context of invasive fungal infections (IFIs), where outcomes are strongly dependent on host immu...
An introduction to the machine learning lifecycle for clinical microbiology [0.03%]
临床微生物学中的机器学习生命周期简介
Imane Lboukili,Benjamin R McFadden,Tavpritesh Sethi et al.
Imane Lboukili et al.
Background: Clinical microbiology is undergoing rapid transformation driven by modern technologies generating high-volume, high-dimensional, and heterogeneous datasets that exceed the analytical capabilities of traditiona...
Beyond one-sizes-fits-all: the promise and pitfalls of stratified medicine in tuberculosis [0.03%]
超越“一刀切”：分层医学在结核病防治中的利弊
Lorenzo Guglielmetti,Samuel K Sarkodie,Rada Savic et al.
Lorenzo Guglielmetti et al.
Twenty-one years, twenty hospitals, zero reinfections: Puumala virus follow-up in Styria, Austria [0.03%]
二十一年，二十家医院，零二次感染——奥地利施泰尔马克州的普乌马拉病毒追踪研究
Christina Geiger,Lisa Kriegl,Robert Krause et al.
Christina Geiger et al.
Diagnostic accuracy of the rapid polymyxin test for colistin resistance in Gram-negative bacteria: a systematic review and meta-analysis [0.03%]
头孢他啶-阿维巴坦耐药快速多黏菌素试验诊断准确性系统评价和meta分析
Jaseena C V,Seshadri Reddy Varikasuvu,Heera C P et al.
Jaseena C V et al.
Background: Polymyxins are considered last-resort agents for treating multidrug-resistant Gram-negative infections; however, resistance is increasing worldwide. Broth microdilution is the standard reference method for col...
An updated systematic review on antimicrobial resistance among Salmonella Typhi worldwide [0.03%]
一项关于全球沙门氏菌泰氏菌株抗微生物药物耐药性最新系统评价
Shruti Murthy,Nienke N Hagedoorn,Widyanto P Adhy et al.
Shruti Murthy et al.
Background: Updated evidence on antimicrobial resistance (AMR) among Salmonella Typhi is needed to inform empiric treatment and typhoid prevention, including vaccine introduction. ...
Immunomodulating treatments for bacterial meningitis and viral encephalitis [0.03%]
用于细菌性脑膜炎和病毒性脑炎的免疫调节治疗
Matthijs C Brouwer,Diederik van de Beek
Matthijs C Brouwer
Background: In central nervous system infections, outcome is not only determined by pathogen-mediated injury but also by the host inflammatory response. Inhibition of the immune response has been suggested as an important...