Patients with symmetric Parkinson's disease do poorly with subthalamic stimulation [0.03%]
皮质下刺激治疗对称性帕金森病患者的疗效不佳
Stefanie Theresa Jost,Camilla Atwani,Philipp Alexander Loehrer et al.
Stefanie Theresa Jost et al.
Background: Motor asymmetry is a hallmark of Parkinson's disease (PD), but ~20% of patients present with symmetric motor signs, which are associated with faster disease progression and poorer dopaminergic response. The im...
Physical activity decreases the likelihood of peripheral neuropathy in persons with diabetes [0.03%]
运动可降低糖尿病患者发生外周神经病变的风险
Evan L Reynolds,David Russman,Georgios Baskozos et al.
Evan L Reynolds et al.
Background: Clinical guidelines recommend physical activity (PA) to prevent diabetic peripheral neuropathy (DPN). However, these recommendations lack specificity in terms of optimal PA intensity and duration. We aimed to ...
Is it time for the removal of valproate restrictions in men? Further evidence from a new study [0.03%]
去掉男性使用丙戊酸钠的禁忌？一项新研究提供了更多证据
Heather Angus-Leppan
Heather Angus-Leppan
Clinical and laboratory features of juvenile-onset anti-NF155 autoimmune nodopathy [0.03%]
抗NF155自身免疫性节结病的临床和实验室特征
Xinmei Wen,Li Di,Wenjia Zhu et al.
Xinmei Wen et al.
Background: Neurofascin 155 autoimmune nodopathy (NF155 AN) is a recently recognised immune-mediated neuropathy distinct from chronic inflammatory demyelinating polyneuropathy. While adult-onset cases have been increasing...
Cumulative cognitive benefits and brain volume change with anti-amyloid therapies for Alzheimer's disease [0.03%]
抗淀粉样蛋白治疗阿尔茨海默病的认知累积获益及其对脑体积的影响
Yu-Hsuan Lin,Tien-Wei Hsu,Yu-Chen Kao et al.
Yu-Hsuan Lin et al.
Objective: This study aimed to evaluate the cumulative benefits of Food and Drug Administration (FDA)-approved monoclonal antibodies (mABs), administered at FDA-approved dosing regimens in slowing cognitive decline compar...
Heiko M Rust,John F Golding,Anja Palmowski-Wolfe et al.
Heiko M Rust et al.
Respiratory function in Becker muscular dystrophy: a comprehensive longitudinal study [0.03%]
贝克尔肌营养不良的呼吸功能：一项纵向研究
Pietro Riguzzi,Emma Grover,Marianela Schiava et al.
Pietro Riguzzi et al.
Background: Becker muscular dystrophy (BMD) is a rare X-linked neuromuscular disorder predominantly affecting males. While respiratory function has been characterised in small cohorts over limited time frames, comprehensi...
Safety of breastfeeding under monoclonal antibodies in the offspring of mothers with multiple sclerosis or neuromyelitis optica spectrum disorder [0.03%]
单克隆抗体治疗多发性硬化症或视神经脊髓炎谱系病母亲的母乳喂养安全性及其后代的安全性评估
Laura Witt,Natalia Friedmann,Sabrina Haben et al.
Laura Witt et al.
Background: Women with multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD) and highly active disease may benefit from early post partum reinitiation of disease-modifying therapy (DMT), but safety dat...
Intravenous methylprednisolone as add-on induction therapy for chronic inflammatory demyelinating polyradiculoneuropathy: a randomised controlled trial [0.03%]
慢性炎症性脱髓鞘多发神经病的静脉甲基强的松龙序贯诱导疗法：随机对照试验
Sander R M Bus,Iris N van Doorn,Laura Zambreanu et al.
Sander R M Bus et al.
Background: Most patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) require maintenance treatment. We aimed to determine whether combined treatment with intravenous immunoglobulin (IVIg) and in...
Defining Alzheimer's disease: stipulations and the ethics of diagnostic change [0.03%]
阿尔茨海默病的诊断标准及其伦理问题
Robin Michalon,Vincent Planche,Maël Lemoine et al.
Robin Michalon et al.