Sijia Zhao,Rong Ye,Aayushi Sen et al.
Sijia Zhao et al.
Background: Apathy, depression and anhedonia are clinically overlapping constructs, which hinders diagnostic clarity and treatment development. This study aimed to comprehensively characterise these syndromes to identify ...
Timing of high-dose folic acid supplementation in the periconceptional period among women taking antiseizure medications and risk of major congenital anomalies: a target trial emulation [0.03%]
围产期接受抗癫痫药物治疗的女性在 peri-conception 时期补充高剂量叶酸的时机与重大先天性畸形风险：目标试验模拟研究
Yuelian Sun,Silje Alvestad,Jacqueline M Cohen et al.
Yuelian Sun et al.
Background: High-dose folic acid supplementation is recommended for women using antiseizure medication (ASMs) to reduce risk of major congenital anomalies (MCAs) in offspring, but evidence is lacking. ...
Migration status, country of origin and long-term outcomes in multiple sclerosis: a Swedish nationwide study [0.03%]
Anna Karin Hedström,Tomas Olsson ,Lars Alfredsson
Anna Karin Hedström
Background: Multiple sclerosis (MS) shows marked geographic and ethnic variation, but the contribution of migration status and region of origin to long-term outcomes remains uncertain. We aimed to examine disability, cogn...
Marina Romozzi,Lucia Di Nardo,Luigi Francesco Iannone et al.
Marina Romozzi et al.
Adherence to the MIND diet and longitudinal brain structural changes over a decade: evidence from the Framingham heart study offspring cohort [0.03%]
MIND饮食依从性和纵向脑结构十年变化：来自弗明汉心脏研究后代队列的证据
Hui Chen,Gulisiya Hailili,Lu-Sha Tong et al.
Hui Chen et al.
Background: The MIND diet was favourably linked to lower risk of neurodegenerative diseases. While previous cross-sectional studies implied its beneficial associations with brain imaging markers, its associations with lon...
Functional and effective connectivity disruptions of the dopaminergic reward circuit in multiple sclerosis patients with depression [0.03%]
多发性硬化抑郁患者的奖赏环路功能性及有效联接异常
Giada Lombardi,Elisa Leveraro,Emilio Cipriano et al.
Giada Lombardi et al.
Background: Despite the impact of depression in multiple sclerosis (MS), the neurobiological mechanisms underlying its pathogenesis are still poorly understood. Disrupted functional connectivity (FC) within the reward cir...
Clinically reported covert cerebrovascular disease and risk of neurological disease: a whole-population cohort of 367 988 people using natural language processing [0.03%]
基于自然语言处理的367988人的全人群队列中的隐匿性脑血管疾病与神经科疾病的发病风险关系研究
Matthew Henry Iveson,Mome Mukherjee,Emma M Davidson et al.
Matthew Henry Iveson et al.
Background: The relevance of covert cerebrovascular disease (CCD) in practice is uncertain, partly because estimation of risk in whole clinical populations is difficult. Studies have had success extracting CCD from clinic...
Sex-related and age-related differences in healthcare use before multiple sclerosis symptom onset: a matched cohort study [0.03%]
多发性硬化症症状发作前的医疗保健利用与患者的年龄和性别之间的关系：一项队列匹配研究
Marta Ruiz-Algueró,Feng Zhu,Farahnaz Amini et al.
Marta Ruiz-Algueró et al.
Background: Increased healthcare use precedes classical multiple sclerosis (MS) symptom onset. Limited evidence exists on sex and age variation. We assessed physician visit patterns pre-MS onset by sex and age. ...
Echocardiographic wall motion abnormalities in patients with stroke may warrant cardiac evaluation [0.03%]
卒中患者超声心动图异常可能需要心脏评估
Shadi Yaghi,Andrew D Chang,Brittany A Ricci et al.
Shadi Yaghi et al.
Background: The aetiology of wall motion abnormalities (WMA) in patients with ischaemic stroke is unclear. We hypothesised that WMAs on transthoracic echocardiography (TTE) in the setting of ischaemic stroke mostly reflec...
Risk of neurodevelopmental disorders associated with paternal use of valproate during spermatogenesis [0.03%]
父亲在精子发生期间使用丙戊酸与神经发育障碍的相关风险
Neda Razaz,Jonas Soderling,Torbjörn Tomson et al.
Neda Razaz et al.
Background: Regulatory authorities have raised concerns about potential teratogenic and neurodevelopmental disorders (NDDs) risks associated with paternal valproate use during spermatogenesis, leading to restrictions. We ...