Evaluation of metformin for epilepsy prevention or seizure control in people without evidence of diabetes: retrospective cohort study [0.03%]
二甲双胍预防或控制无糖尿病证据者的癫痫发作：回顾性队列研究
Gashirai K Mbizvo,Josephine Mayer,Sneha Mary George et al.
Gashirai K Mbizvo et al.
Background: Metformin demonstrates antiepileptogenic (primary prevention) and antiseizure (symptom control) properties in animal models of epilepsy. It is unclear whether these effects translate to humans, particularly ou...
Deconstructing the association of metformin with reduced incidence of seizures and improved seizure control [0.03%]
二甲双胍降低癫痫发作发生率和改善癫痫控制的作用机制探究
Wesley T Kerr,Katherine N McFarlane
Wesley T Kerr
Risk of neurodevelopmental disorders associated with paternal use of valproate during spermatogenesis: a living meta-analysis-version 1 [0.03%]
父亲在精子发生期间使用丙戊酸与神经发育障碍相关联的风险：一期现场meta分析研究
Jakob Christensen,Betina B Trabjerg,Marleen M H J van Gelder et al.
Jakob Christensen et al.
Objective: To evaluate the association of paternal use of valproate during spermatogenesis compared with paternal use of lamotrigine or levetiracetam on offspring risk of neurodevelopmental disorders (NDDs). ...
The study of epigenetic clocks in former professional contact sports athletes with repetitive head impacts [0.03%]
重复头部撞击的前职业接触式运动员的表观遗传钟研究
Xuelin Tang,Vishaal Sumra,Christine Sato et al.
Xuelin Tang et al.
Background: Repetitive head impacts in former contact sport athletes are associated with cognitive impairment, accelerated cerebral atrophy and risk of neurodegenerative disease. Epigenetic clocks derived from age-associa...
Predictors of B-cell repopulation in people with multiple sclerosis treated with ocrelizumab: insights from two large cohorts [0.03%]
奥法木单抗治疗的多发性硬化患者的B细胞再增殖预测因素：来自两大队列的启示
Laura Hogenboom,Antonia McLean,Lisa Schoof et al.
Laura Hogenboom et al.
Background: Evidence indicates that B-cell dynamics during ocrelizumab treatment vary among individuals with multiple sclerosis. However, our understanding of B-cell dynamics is incomplete. We aim to characterise temporal...
Aetiological factors in functional seizures and functional motor symptoms: shared and distinct features [0.03%]
功能性癫痫发作和运动症状的发病因素：相同点与不同点
L S Merritt Millman,Snigdha Bhuma,Yasmine Basamh et al.
L S Merritt Millman et al.
Background: Functional seizures (FS) and functional motor symptoms (FMS), subtypes of functional neurological disorder, may involve shared and distinct predisposing, precipitating, perpetuating and triggering (PPPT) facto...
Recovery of daily life upper limb use during stroke rehabilitation: neuroanatomical correlates and associated variables [0.03%]
缺血性卒中康复患者上肢功能使用的恢复及其相关脑区和影响因素研究
Janne Marieke Veerbeek,Brigitte Charlotte Kaufmann,Beatrice Ottiger et al.
Janne Marieke Veerbeek et al.
Background: Early after stroke, the upper limb is impaired in ~50% of patients who had a stroke, posing a significant and restrictive challenge to their daily lives. It is unknown how many subacute stroke patients regain ...
Autologous haematopoietic stem cell transplantation in multiple sclerosis: outcomes and predictors from German real-world data [0.03%]
德国真实世界数据指导下的多发性硬化自体造血干细胞移植的结局及预测因素分析
Felix Fischbach,Johanna Richter,Miriam Korporal-Kuhnke et al.
Felix Fischbach et al.
Background: Autologous haematopoietic stem cell transplantation (aHSCT) represents a treatment option for highly aggressive multiple sclerosis (MS). Here, we report outcome analyses from the two largest German centres per...
Relapse-associated worsening in apolipoprotein E ε4 carriers with relapsing multiple sclerosis [0.03%]
复发型多发性硬化病HDL-C降低与APOEε4基因型相关
Emilio Portaccio,Maria Grazia Aprea,Ermelinda De Meo et al.
Emilio Portaccio et al.
Background: In multiple sclerosis (MS), disability accrual can arise from relapse-associated worsening (RAW) and progression independent of relapse activity (PIRA). While genetic variants associated with increased MS seve...
Incidence and prevalence of small fibre neuropathy in the Netherlands: a multiple system estimation study [0.03%]
荷兰小纤维神经病变的患病率和发病率：一项多系统估计研究
Dennis Kool,Janneke G J Hoeijmakers,Catharina G Faber et al.
Dennis Kool et al.
Background: Small fibre neuropathy (SFN) affects small myelinated Aδ- and unmyelinated C-fibres and causes neuropathic pain and autonomic symptoms. Earlier Dutch estimates, over a decade old, reported a minimum prevalenc...