Structure-function-treatment relationships of aerosol deposition in patients with severe asthma [0.03%]
重度哮喘患者气溶吸入结构-功能-治疗关系研究
Omar Usmani,Sylvia Verbanck
Omar Usmani
Classifying ARDS by dynamic or static oxygenation impairment or are other approaches needed for greater value [0.03%]
动态或静态氧合损伤分类ARDS或是其他方法可增加更多价值？
Marcus J Schultz,Denise Battaglini,Prashant Nasa
Marcus J Schultz
Patrick Brian Murphy,Swapna Mandal
Patrick Brian Murphy
Impact of long-term non-invasive ventilation on severe exacerbations and survival in COPD: a French nationwide cohort study using multistate models [0.03%]
长期无创通气对慢性阻塞性肺疾病患者急性加重和生存的影响：使用多状态模型的法国全国队列研究
Jean Louis Pépin,Eleonore Herquelot,Helene Denis et al.
Jean Louis Pépin et al.
Rationale: Chronic obstructive pulmonary disease (COPD) is the most common indication for domiciliary non-invasive ventilation (NIV), but long-term outcomes data are limited. ...
Systematic review and meta-analysis of the efficacy of biologic and targeted synthetic therapies in sarcoidosis [0.03%]
生物制剂和靶向合成药物治疗肉芽肿性皮肤病的疗效系统评价和meta分析研究
Katie Bechman,Kathryn Biddle,Aitana Miracle et al.
Katie Bechman et al.
Objectives: Infliximab, an anti-TNF agent, is used to treat sarcoidosis that does not respond to corticosteroids or second-line agents. The efficacy of other anti-TNF agents, non-TNF biologics and targeted synthetic thera...
Dynamic oxygenation subgroup bringing new insights in ARDS: more predictive of outcomes and response to PEEP than static PaO2/FiO2 [0.03%]
动态氧合亚组给ARDS带来了新的启示：比静态PaO2/FiO2更预测结局和对PEEP的反应
Yu Bai,Shengsong Chen,Haopu Yang et al.
Yu Bai et al.
Background: Acute respiratory distress syndrome (ARDS) is a rapidly evolving condition. Dynamic assessments using patient trajectories may provide novel insights into disease heterogeneity. The primary objective of this s...
Oxygen therapy in early warning scores: a systematic review and meta-analysis [0.03%]
早期预警评分与氧疗：系统评价和荟萃分析
Charlotte H Harrison,Phoebe Tupper,Stephen Gerry et al.
Charlotte H Harrison et al.
Background: Early warning systems (EWS) used across the world typically assign a fixed number of points to patients receiving supplemental oxygen, regardless of amount. This ordinal binary approach may fail to recognise d...
Severe community-acquired pneumonia (sCAP): advances in management and future directions [0.03%]
社区获得性肺炎(CAP)的重症期：治疗进展与未来方向
Ignacio Martin-Loeches,Luis Felipe Reyes,Alejandro Rodriguez
Ignacio Martin-Loeches
Severe community-acquired pneumonia (sCAP) is a major global health challenge, with high morbidity and mortality, especially among patients requiring intensive care. Despite advancements in antimicrobial therapies and supportive care, sCAP ...
Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19: a randomised, controlled, open-label, adaptive platform trial [0.03%]
托珠单抗、萨利珠单抗和依那西普在重症新冠肺炎患者中的疗效：一项随机、适应性平台试验
Lennie Derde,Anthony C Gordon,Paul R Mouncey et al.
Lennie Derde et al.
Introduction: Tocilizumab improves outcomes in critically ill patients with COVID-19. Whether other immune-modulator strategies are equally effective or better is unknown. ...
Effect of viloxazine and trazodone in obstructive sleep apnoea: a randomised, placebo-controlled, cross-over study [0.03%]
利洛西嗪和曲唑酮对阻塞性睡眠呼吸暂停的影响：随机、安慰剂对照交叉试验
Atqiya Aishah,Molly Kim,Laura Gell et al.
Atqiya Aishah et al.
Introduction: Combination of the noradrenergic atomoxetine with either the antimuscarinic aroxybutynin or trazodone has been shown to improve obstructive sleep apnoea (OSA) severity. However, atomoxetine may contribute to...