Molecular scissors for inflamed lungs: targeting ubiquitin-specific peptidases in acute lung injury [0.03%]
用于炎症肺的分子剪刀：急性肺损伤中的泛素特异性肽酶靶向疗法
Hannah Rose McLeod,Suguru Yamamoto,Koichi Yuki
Hannah Rose McLeod
Body composition is associated with nintedanib-related diarrhoea: risk stratification in idiopathic pulmonary fibrosis [0.03%]
身体组成与尼达尼布相关腹泻有关：特发性肺纤维化患者的危险分层
Ilaria Bassi,Marco Carpano,Gilda Giancotti et al.
Ilaria Bassi et al.
Diarrhoea is the primary cause of nintedanib discontinuation in idiopathic pulmonary fibrosis. We investigated predictors in 100 prospective patients; 46% experienced diarrhoea, defined as common terminology criteria for adverse events V.5....
Optimal timing, duration and sequencing of therapy for progressive pulmonary fibrosis: the urgent need to move beyond the 'wait-to-fail' paradigm [0.03%]
进展性肺纤维化治疗的最佳时机、疗程和序贯疗法：亟需超越“等待失败”模式
Adhnan Omar,Philip Evans,Nicola Hutchinson
Adhnan Omar
Visible mould and blood inflammatory phenotypes of asthma in adults: the CONSTANCES cohort [0.03%]
成人哮喘中可见霉菌和血液炎症表型：CONSTANCES队列研究
Tajidine Tsiavia,Joseph Henny,Emilie Fréalle et al.
Tajidine Tsiavia et al.
Studying the associations between indoor mould contamination and blood inflammatory phenotypes may provide further insight into the mechanisms by which this environmental factor affects asthma.Among 1870 adults with current asthma from a po...
Minimum important difference for the incremental shuttle walk test in long covid rehabilitation [0.03%]
用于长新冠康复的增量 shuttle 步行测试的最小重要差异
Molly M Baldwin,Enya Daynes,Rachael A Evans et al.
Molly M Baldwin et al.
The minimum important difference (MID) for the incremental shuttle walk test (ISWT) in individuals with long covid was estimated using anchor-based and distribution-based methods. 397 participants (56 ± 13 years; 63.7% male) with long covi...
Ali Doryab,Motaharehsadat Heydarian,Clare Bryant et al.
Ali Doryab et al.
Background: The human lung hosts a highly specialised immune microenvironment responsible for defence, repair and responses to pathogens and environmental insults. Animal models insufficiently recapitulate human-specific ...
Unsupervised home spirometry versus supervised clinic spirometry: analysis of longitudinal participant-level data from the CLEAR trial in patients with bronchiectasis [0.03%]
无需监督的居家肺功能测试与需要监督的诊所肺功能测试的对比：来自支气管扩张症患者CLEAR试验的纵向受试者水平数据分析
Ryan McChrystal,Rebecca H McLeese,Brenda O&#x;Neill et al.
Ryan McChrystal et al.
Background: Lung function measurement is central to assessing disease severity and monitoring progression in bronchiectasis. Although home spirometry is convenient for remote monitoring, there is limited evidence for its ...
Implementation and outcomes of drug response assessments for inhaled hypertonic saline in bronchiectasis: a post hoc analysis of the CLEAR trial [0.03%]
超渗素盐吸入对支气管扩张药物反应的评估及其结果：来自CLEAR试验的事后分析
Rebecca H McLeese,Brenda O&#x;Neill,Daniel F McAuley et al.
Rebecca H McLeese et al.
Introduction: A drug response assessment (DRA) is recommended before starting patients on hypertonic saline (HTS) due to the risk of bronchoconstriction. As part of the CLEAR trial (a randomised, open-label trial of HTS a...
Inhaled and oral corticosteroid use and the risk of pulmonary aspergillosis: a Danish population-based case-control study [0.03%]
吸入及口服皮质类固醇的使用与肺曲霉病风险的关系：一项丹麦人群基于病例对照的研究
Alexander Jordan,Louise Lindhardt Toennesen,Bård-Emil Vang Gundersen et al.
Alexander Jordan et al.
Background: Pulmonary aspergillosis is a rare, high mortality lung infection caused by the Aspergillus sp. Chronic lung diseases and immunosuppression are known risk factors, but data on the impact of corticosteroids and ...
David W Denning
David W Denning