COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms [0.03%]
新冠肺炎、免疫血栓和静脉血栓栓塞：生物学机制
Joan Loo,Daniella A Spittle,Michael Newnham
Joan Loo
Thrombotic events that frequently occur in COVID-19 are predominantly venous thromboemboli (VTE) and are associated with increasing disease severity and worse clinical outcomes. Distinctive microvascular abnormalities in COVID-19 include en...
Structural airway imaging metrics are differentially associated with persistent chronic bronchitis [0.03%]
结构气道影像学指标与慢性支气管炎的持久性相关
Surya P Bhatt,Sandeep Bodduluri,Abhilash S Kizhakke Puliyakote et al.
Surya P Bhatt et al.
Background: Chronic bronchitis (CB) is strongly associated with cigarette smoking, but not all smokers develop CB. We aimed to evaluate whether measures of structural airway disease on CT are differentially associated wit...
Current smoking and COVID-19 risk: results from a population symptom app in over 2.4 million people [0.03%]
吸烟与新冠肺炎易感性：一项覆盖240万以上的手机症状监测项目的结果分析
Nicholas S Hopkinson,Niccolo Rossi,Julia El-Sayed Moustafa et al.
Nicholas S Hopkinson et al.
Background: The association between current tobacco smoking, the risk of developing symptomatic COVID-19 and the severity of illness is an important information gap. ...
Geo-social gradients in predicted COVID-19 prevalence in Great Britain: results from 1 960 242 users of the COVID-19 Symptoms Study app [0.03%]
英国新冠症状研究应用程序用户新冠病毒肺炎发病率的空间社会分布：一项基于1 960 242名用户的队列研究
Ruth C E Bowyer,Thomas Varsavsky,Ellen J Thompson et al.
Ruth C E Bowyer et al.
Understanding the geographical distribution of COVID-19 through the general population is key to the provision of adequate healthcare services. Using self-reported data from 1 960 242 unique users in Great Britain (GB) of the COVID-19 Sympt...
Managing intensive care admissions when there are not enough beds during the COVID-19 pandemic: a systematic review [0.03%]
新冠肺炎疫情下床位资源不足时危重症收治的管理：系统综述
Carina S B Tyrrell,Oliver T Mytton,Sarah V Gentry et al.
Carina S B Tyrrell et al.
The surge in cases of severe COVID-19 has resulted in clinicians triaging intensive care unit (ICU) admissions in places where demand has exceeded capacity. In order to assist difficult triage decisions, clinicians require clear guidelines ...
Functional electrical stimulation in-bed cycle ergometry in mechanically ventilated patients: a multicentre randomised controlled trial [0.03%]
机械通气患者床上功能性电刺激踏车运动治疗：多中心随机对照试验
Sue Berney,Ramona O Hopkins,Joleen Wyn Rose et al.
Sue Berney et al.
Purpose: To investigate the effect of functional electrical stimulation-assisted cycle ergometry (FES-cycling) on muscle strength, cognitive impairment and related outcomes. ...
Randomized Controlled Trial
Thorax. 2021 Jul;76(7):656-663. DOI:10.1136/thoraxjnl-2020-215093 2021
Are mesenchymal stem cells and derived extracellular vesicles valuable to halt the COVID-19 inflammatory cascade? Current evidence and future perspectives [0.03%]
间充质干细胞和衍生的外泌体对阻断COVID-19炎症级联反应有价值吗？现有证据和未来展望
Marta Monguió-Tortajada,Antoni Bayes-Genis,Antoni Rosell et al.
Marta Monguió-Tortajada et al.
David C Christiani
David C Christiani
Variation in oral microbiome is associated with future risk of lung cancer among never-smokers [0.03%]
口腔微生物组的变异与从未吸烟者未来患肺癌的风险有关
H Dean Hosgood,Qiuyin Cai,Xing Hua et al.
H Dean Hosgood et al.
Objective: To prospectively investigate whether diversity in oral microbiota is associated with risk of lung cancer among never-smokers. Design and settin...
Multicenter Study
Thorax. 2021 Mar;76(3):256-263. DOI:10.1136/thoraxjnl-2020-215542 2021
Gene coexpression networks reveal novel molecular endotypes in alpha-1 antitrypsin deficiency [0.03%]
基因共表达网络揭示了α1抗胰蛋白酶缺乏的新分子亚型
Jen-Hwa Chu,Wenlan Zang,Milica Vukmirovic et al.
Jen-Hwa Chu et al.
Background: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition that causes early onset pulmonary emphysema and airways obstruction. The complete mechanisms via which AATD causes lung disease are not fully unders...
Multicenter Study
Thorax. 2021 Feb;76(2):134-143. DOI:10.1136/thoraxjnl-2019-214301 2021