Acute breathlessness as a cause of hospitalisation in Malawi: a prospective, patient-centred study to evaluate causes and outcomes [0.03%]
马拉维因急性呼吸困难住院患者的病因及结局的前瞻性、以患者为中心的研究
Stephen A Spencer,Florence Malowa,David McCarty et al.
Stephen A Spencer et al.
Introduction: Breathlessness is a common cause of hospital admission globally and is associated with high mortality, particularly in low-income countries. In sub-Saharan Africa, there is a paucity of data on breathlessnes...
Real-world effectiveness and safety of nirsevimab, RSV maternal vaccine and RSV vaccines for older adults: a living systematic review and meta-analysis [0.03%]
nirsevimab、RSV母体疫苗和适用于老年人的RSV疫苗的真实世界有效性和安全性：一项动态系统评价和meta分析
Bohee Lee,Daira Trusinska,Sohail Ferdous et al.
Bohee Lee et al.
Background: The long-acting monoclonal antibody nirsevimab and respiratory syncytial virus (RSV) vaccines became available for prevention of severe RSV-associated disease in 2023. While clinical trials showed good efficac...
Multimodality curative-intent treatment in NSCLC: an unprecedented era of change 2017-2025 [0.03%]
2017-2025年肺癌治愈性综合治疗的变革期
Matthew Evison,Tanya Ahmed,Meenali Chitnis et al.
Matthew Evison et al.
Curative-intent multimodality treatment-combining local treatments such as surgery or radiotherapy with systemic therapy-is the cornerstone of care in stage II-III non-small cell lung cancer (NSCLC). Since 2017, the systemic therapy backbon...
Spirometry thresholds for clinical trial eligibility: time for urgent re-evaluation [0.03%]
紧急重新评估肺功能阈值以确定临床试验入组资格的时刻到了
Idan Bokobza,Melanie Le Sayec,Cara Bossley et al.
Idan Bokobza et al.
A common eligibility criterion in respiratory clinical trials is a per cent-predicted forced expiratory volume in 1 second (ppFEV1) between 40% and 90%, using the ethnicity-dependent Global Lung Function Initiative (GLI)-2012 spirometry ref...
Early prediction of bronchopulmonary dysplasia by urinary metabolomics: a case-control study [0.03%]
尿液代谢组学早期预测支气管肺发育不良的病例对照研究
Luca Bonadies,Serena Calgaro,Matteo Stocchero et al.
Luca Bonadies et al.
Objective: Bronchopulmonary dysplasia (BPD), the most frequent complication of extreme preterm birth, lacks not only of a comprehensive definition but also of effective treatments and predictive tools. Metabolomics is a v...
Impact of regional asthma guidelines on SABA prescribing patterns across England: an interrupted time series analysis [0.03%]
英国各地实施哮喘防治地区指南对短期速效β2受体激动剂的处方模式的影响：一项中断时间序列分析
Dominic L Sykes,Michael D Clarkson,Anita Negbenebor et al.
Dominic L Sykes et al.
The 2024 British Thoracic Society/ National Institute for Health and Care Excellence/ Scottish Intercollegiate Guidelines Network asthma guidelines recommend anti-inflammatory reliever (AIR)-based management, providing opportunity to reduce...
Paternal prepubertal passive smoke exposure is related to impaired lung function trajectories from childhood to middle age in their offspring [0.03%]
父辈童年时期的被动吸烟暴露与后代从儿童期到中年期的肺功能轨迹受损有关
Jiacheng Liu,Jennifer L Perret,Caroline J Lodge et al.
Jiacheng Liu et al.
Introduction: Paternal prepubertal passive smoke exposure may increase the risk of childhood asthma. However, its association with impaired lung function trajectories at risk of chronic obstructive pulmonary disease in of...
Interferon gamma applied ex vivo restores function to neutrophils from critically ill patients [0.03%]
干扰素γ体外处理可恢复重症患者中中性粒细胞的功能
Cameron J Lake,Jonathan Scott,Marie-Hélène Ruchaud-Sparagano et al.
Cameron J Lake et al.
Introduction: Critically ill patients commonly develop acquired neutrophil dysfunction, which increases susceptibility to intensive care unit-acquired infection (ICU-AI). This study aimed to assess whether interferon gamm...
Challenges in respiratory medicine: the need for integrated tuberculosis and respiratory care in low-resource settings [0.03%]
呼吸系统医学的挑战——低资源环境下综合防治结核病与呼吸系统疾病的需求
Jacqueline Wanjiku Kagima,Obianuju B Ozoh,Stellah Mpagama et al.
Jacqueline Wanjiku Kagima et al.
Background: Pulmonary tuberculosis (PTB) and chronic respiratory diseases (CRDs) are intricately linked. People with PTB and CRDs experience similar symptoms, including breathlessness, cough and chest pain. They may have ...
Gabapentinoids and risk for asthma exacerbations: a nationwide retrospective cohort study [0.03%]
加巴喷丁类药物与哮喘急性发作风险：一项全国性回顾队列研究
Yuya Kimura,Taisuke Jo,Norihiko Inoue et al.
Yuya Kimura et al.
Introduction: Despite warnings from the US Food and Drug Administration about respiratory adverse events associated with gabapentinoids, direct evidence of their risk in patients with asthma is lacking. ...