Feasibility and acceptability of an unsupervised and adapted physical activity program (PACE tool) as pragmatic care in a geriatric outpatient clinic [0.03%]
在老年门诊中作为实用护理的无监管且可适应的身体活动方案（PACE工具）的可行性和接受度研究
Ruiz Fabien Jean Manuel,Kergoat Marie-Jeanne,Buckinx Fanny et al.
Ruiz Fabien Jean Manuel et al.
Background: Physical inactivity accelerates the ageing process, leading functional incapacities and physical dependence. Although physical activity (PA) is known to counteract these effects, its integration as a prescript...
Proteomic profiling of bone tissue reveals distinct pathways in men and women with osteoporosis [0.03%]
骨组织蛋白质组学特征发现男性和女性特异的绝经后骨质疏松症机制
Xiaoyun Lin,Jing Hu,Hengyan Zhang et al.
Xiaoyun Lin et al.
Background: Osteoporosis is characterised by an imbalance in bone remodelling, yet the detailed molecular mechanisms underlying its pathogenesis remain unclear. This study aimed to identify key proteins and regulatory pat...
Delirium prevalence, diagnostic uncertainty and outcomes in ORCHARD-EPR: validation against prospective reference cohorts [0.03%]
大型前瞻性队列研究中谵妄患病率、诊断不确定性和预后：与前瞻性参照队列的验证性研究结果
Emily Louise Boucher,Jasmine Ming Gan,Nicola Georgia Lovett et al.
Emily Louise Boucher et al.
Background: Delirium is underdiagnosed in older inpatients. We determined clinically ascertained delirium prevalence, characteristics and outcomes after implementation of mandatory cognitive/delirium screening via the ele...
'I am old, and I will rather abandon life with my eyes open': a qualitative study of Norwegians aged 80 and older explaining their intensive care unit admission preferences [0.03%]
“我老了，愿意睁着眼睛离开人世”：关于挪威80岁以上老年人对重症监护病房收治意愿的定性研究
Gabriele Leonie Schwarz,Britt Ågot Sjøbø,Elisabeth Skaar et al.
Gabriele Leonie Schwarz et al.
Background: The treatment preferences of patients aged 80 and older in the event of acute critical illness vary widely and are difficult to predict. To provide the appropriate level of care, it is necessary to better unde...
The development, acceptability and preliminary efficacy of a sleep health intervention on frailty and quality of life in older adults [0.03%]
老年人睡眠健康干预的开发、可接受性和初步有效性及其对脆弱性、生活质量的影响研究
Lauren K Hand,Eryen Nelson,Allison Glaser et al.
Lauren K Hand et al.
Objective: Aim 1 was to assess feasibility, acceptability and tailor a sleep health intervention for older adults. Aim 2 was to evaluate the impact of the intervention on sleep, frailty and quality of life. ...
Randomized Controlled Trial
Age and ageing. 2025 Aug 29;54(10):afaf287. DOI:10.1093/ageing/afaf287 2025
Lived experiences of missing with dementia and pathways to care: a qualitative study of carers' and professionals' perspectives [0.03%]
痴呆患者迷路的个人经历及其就医途径：照料者和专业人士的视角定性研究
Phuong Leung,Valerie Lye,Hoi Tat Kwok et al.
Phuong Leung et al.
Background: People with dementia are at increased risk of going missing, which can lead to severe harm and distress. Despite the need for a better understanding of how to support people with dementia and their families af...
Long-acting intranasal insulin for the treatment of delirium-a randomised clinical trial [0.03%]
长效鼻用胰岛素治疗谵妄的临床研究
Anita Nitchingham,Jacqueline C T Close,Lara Ann Harvey et al.
Anita Nitchingham et al.
Background: Delirium affects up to 25% of hospitalised older patients; however, there are no effective pharmacological treatments. Accumulating evidence of brain insulin resistance and altered cerebral glucose metabolism ...
Randomized Controlled Trial
Age and ageing. 2025 Aug 29;54(10):afaf276. DOI:10.1093/ageing/afaf276 2025
Life satisfaction and risk of dementia in older adults: findings from 15 European countries and meta-analysis [0.03%]
欧洲15个国家老年人生活满意度与患痴呆症风险的相关性研究及元分析发现
Selin Karakose,Amanda A Miller,Martina Luchetti et al.
Selin Karakose et al.
Background: Life satisfaction (LS) is associated with lower morbidity and mortality. However, the evidence linking LS to dementia remains limited, with no studies from Europe. Prior studies also differ in the measurement ...
Meta-Analysis
Age and ageing. 2025 Aug 29;54(10):afaf292. DOI:10.1093/ageing/afaf292 2025