Real-world effectiveness of SGLT2 inhibitors in adults aged 75 years or older: a target trial emulation [0.03%]
Hisashi Noma,Atsushi Goto,Taiki Sugimoto et al.
Hisashi Noma et al.
Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) improve cardiovascular and renal outcomes, but evidence in adults aged ≥75 years remains limited, particularly compared with dipeptidyl peptidase-4 inhibitor...
A randomised, double-blind, placebo-controlled crossover trial on cannabinoid-based medication for behavioural disorders in old patients with severe dementia: the study results [0.03%]
Federica Bianchi,Barbara Broers,Jules Alexandre Desmeules et al.
Federica Bianchi et al.
Background: Behavioural and psychological symptoms of dementia (BPSD) are frequent in patients with severe dementia and represent a major clinical challenge. Cannabinoid-based medications (CBM) have been proposed as a pos...
Randomized Controlled Trial
Age and ageing. 2026 Aug 3;55(8):afag239. DOI:10.1093/ageing/afag239 2026
Antidepressants at the threshold: what is really driving prescribing around dementia diagnosis? [0.03%]
Chengjun Liu,Katharine A Wallis
Chengjun Liu
Deprescribing antihypertensive drugs in patients aged over 80 years: an evidence-based way forward [0.03%]
Denis O&#x;Mahony
Denis O&#x;Mahony
Roy L Soiza
Roy L Soiza
Antony Johansen
Antony Johansen
Effectiveness and safety of focused deprescribing interventions targeting specific drug classes in older adults across clinical settings: an umbrella systematic literature review [0.03%]
针对临床环境下老年患者特定药物类别的停药干预的有效性和安全性：系统性文献回顾伞式评审
Ángel García Álvarez,Pau Riera Serra,Ignacio Ricci-Cabello et al.
Ángel García Álvarez et al.
Polypharmacy is highly prevalent among older adults and is associated with adverse outcomes. While comprehensive medication review is widely promoted to address potentially inappropriate prescribing, it is resource intensive. Focused depres...
Comparing frailty index distribution, mortality and frailty dynamics across multiple countries: applying the 'zero-state' principle to harmonised ageing data [0.03%]
基于和谐的老龄化数据应用“初始状态”原理跨国家比较脆弱性指数分布、死亡率和脆弱性动态变化
Saskia Drijver-Headley,Judith Godin,Kenneth Rockwood et al.
Saskia Drijver-Headley et al.
Introduction: Frailty is a dynamic state linked to disability, hospitalisation and mortality. Cross-country comparisons of frailty progression remain limited. We compared frailty distribution, mortality risk and deficit a...
Comparative Study
Age and ageing. 2026 Aug 3;55(8):afag242. DOI:10.1093/ageing/afag242 2026
A decade of increasing complexity in patients sustaining a hip fracture in England, Wales and Northern Ireland: a national cohort study using the National Hip Fracture Database dataset [0.03%]
英国、英格兰和北爱尔兰十年来髋部骨折患者的复杂性不断增加：使用国家髋部骨折数据库数据的全国队列研究
Richard James Holleyman,Thomas Baldock,Andre Charlett et al.
Richard James Holleyman et al.
Background: Hip fractures (HF) are a major cause of morbidity and mortality and account for substantial health and social care costs. We report the incidence and characteristics of older patients (≥60 years) presenting w...
Primary care-based post diagnostic dementia care in England: modelling and scaling up evidence-based models for efficient future care [0.03%]
基于初级保健的诊断后痴呆护理：建立和推广高效未来的证据为基础模型护理
Magdalena Walbaum,Derek King,Louise Robinson et al.
Magdalena Walbaum et al.
Background: The global prevalence of dementia is rising rapidly, placing increasing pressure on health and social care systems to deliver coordinated and equitable post-diagnostic support. In England, service fragmentatio...