Effect of multicomponent exercise intervention on multidimensional frailty in older adults with mild cognitive impairment: a secondary analysis of the MIND-STEP randomised clinical trial [0.03%]
Chenlu Hong,Na Zhang,Jiaxiu Sheng et al.
Chenlu Hong et al.
Background: Frailty is common among older adults with mild cognitive impairment (MCI) and encompasses physical, cognitive, psychological and social domains, yet randomised evidence on theory-informed multicomponent exerci...
Randomized Controlled Trial
Age and ageing. 2026 Apr 4;55(4):afag111. DOI:10.1093/ageing/afag111 2026
Impact of sequenced pharmacological optimisation and multicomponent bundle on early delirium severity trajectories in general medical inpatients [0.03%]
E Kyong Yoon,Yuna Jang,Sun-Wook Kim et al.
E Kyong Yoon et al.
Background: Delirium is common in older medical inpatients, associated with prolonged hospitalisation, falls and cognitive decline. Despite recommendations for multicomponent non-pharmacological interventions, the additio...
Projected trends in frailty prevalence and associated health service use and costs in the over-50s in England, 2025 to 2040: a simulation modelling study [0.03%]
Bronagh Walsh,Tracey England,Sally Brailsford et al.
Bronagh Walsh et al.
Aim: To model projected trends in frailty prevalence, associated service use and costs in people aged 50 and over in England to 2040. Design: ...
Jindou Jiang,Pan Li,Jijun Zhu et al.
Jindou Jiang et al.
Skin ageing emerges from the interplay of intrinsic biological decline, environmental exposures and disease-related remodelling, yet the pathway-level epigenetic programs that integrate these processes remain largely unresolved. Here, we de...
Enhancing goals of care discussions: a systematic review and meta-analysis of clinician-directed behavioural nudges [0.03%]
Louisa Poco,Shimoni Shah,Chetna Malhotra
Louisa Poco
Background: Goals of care discussions (GOCDs) are critical for patients with serious illnesses but are hindered by clinician-level barriers. Nudges-low-burden, behaviourally informed strategies that influence clinician be...
Meta-Analysis
Age and ageing. 2026 Apr 4;55(4):afag113. DOI:10.1093/ageing/afag113 2026
Life expectancy estimation in older men using the prostate cancer comorbidity index in VA & SEER-Medicare cohorts [0.03%]
John Heard,Michael Luu,I-Chun Thomas et al.
John Heard et al.
Background: Guidelines endorse specific life expectancy (LE) cutoffs for triage of definitive local treatment of prostate cancer, but the lack of validated, prostate cancer-specific LE prediction tools limits incorporatio...
Observational Study
Age and ageing. 2026 Apr 4;55(4):afag097. DOI:10.1093/ageing/afag097 2026
Priorities for medication management information resources for people with dementia and carers: a community-driven approach using a modified Delphi method [0.03%]
Jacqueline Wesson,Amanda J Cross,Karen Watson et al.
Jacqueline Wesson et al.
Background: Managing medications safely can be challenging for people with dementia and carers living in the community and medication errors can be a source of preventable harm. Resources to support people in medication m...
Heat-related deaths in social care in England: can the Care Quality Commission ratings system be used to identify care homes that would benefit most from heat adaptation measures? [0.03%]
Shakoor Hajat,Shereen Hussein,Keyi Li et al.
Shakoor Hajat et al.
Background: The health impacts of rising temperatures in care home settings are of growing concern. We seek to characterise the risk of heat-related mortality in nursing and residential care home settings in England and t...
Dual-threshold plasma Aβ oligomerization for postoperative delirium risk stratification [0.03%]
双重阈值血浆Aβ寡聚化术后谵妄风险分层
YoungSoon Yang,Ki Jin Jung,Yong Tae Kwak
YoungSoon Yang
Background: Postoperative delirium is common in older surgical patients, but simple blood tests to identify risk are lacking. Plasma amyloid-β oligomers measured by multimer detection (MDS-OAβ) may reflect neurodegenera...