Ketogenic Diet and Thyroid Function: A Delicate Metabolic Balancing Act [0.03%]
生酮饮食与甲状腺功能：微妙的代谢平衡行为
Petar Vranjić,Mladen Vuković,Senka Blažetić et al.
Petar Vranjić et al.
The ketogenic diet (KD), a high-fat, low-carbohydrate diet, causes profound metabolic adaptations that go beyond energy production and affect endocrine function and thyroid hormone regulation. By shifting the body's primary fuel source from...
Exploring CCND1 as a Key Target of Acorus calamus Against RSV Infection: Network Pharmacology, Molecular Docking, and Bioinformatics Analysis [0.03%]
运用网络药理学、分子对接及生物信息学分析探究阿魏川芎藏线虫感染防治关键靶标CCND1的作用机制研究探索石菖蒲抗呼吸道合胞病毒入侵的可能作用机制：网络药理学、分子对接和生物信息学分析
Haojing Chang,Li Shao,Ke Tao et al.
Haojing Chang et al.
Acorus calamus, a traditional Tibetan medicine with potential antiviral activity but undefined mechanisms, was studied for its anti-respiratory syncytial virus (RSV) mechanisms using network pharmacology and molecular docking, given RSV's s...
Chemical Composition of Clove and Fennel Seed Essential Oils and a Comparison of Their In Silico and In Vitro Antibacterial Activity with That of Their Main Compounds [0.03%]
肉桂和小茴香种子精油的化学成分及其体外和计算机模拟抗菌活性与其主要化合物的比较研究
Achraf Abdou,Fatima Ezzahra Maaghloud,Fatima Zahra Kamal et al.
Achraf Abdou et al.
This study aimed to assess the chemical composition and antibacterial potential of essential oils (EOs) from two plants: clove buds (Syzygium aromaticum) and fennel seeds (Foeniculum vulgare) EOs. The major compounds, eugenol and estragole,...
The SMIM25-COX-2 Axis Modulates the Immunosuppressive Tumor Microenvironment and Predicts Immunotherapy Response in Hepatocellular Carcinoma [0.03%]
SMIM25-COX-2轴调节肝细胞癌免疫抑制性肿瘤微环境并预测免疫治疗疗效
Zhenxing Wang,Xia Li,Shiyi Zhang et al.
Zhenxing Wang et al.
Hepatocellular carcinoma (HCC) is a malignancy that is notorious for its dismal prognosis. Dysregulation of the tumor microenvironment (TME) in HCC has emerged as a key hallmark in determining disease progression and the response to immunot...
New Perspectives on the Use of Resveratrol in the Treatment of Metabolic and Estrogen-Dependent Conditions Through Hormonal Modulation and Anti-Inflammatory Effects [0.03%]
从激素调节和抗炎作用的角度探讨白藜芦醇在代谢及雌激素依赖性疾病治疗中应用的新思路
Guilherme Renke,Ana Carolina Fuschini,Beatriz Clivati et al.
Guilherme Renke et al.
Estrogen-dependent conditions, such as endometriosis, adenomyosis, lipedema, polycystic ovary syndrome, and breast cancer, are intimately involved with hormonal changes related to estrogen and their receptors. These conditions can be expres...
Correlation Between In Silico Docking/Simulation Results and In Vitro MAGL Inhibition Potency of Selected Triterpenes [0.03%]
几种三萜化合物分子对接/模拟与体外MAGL抑制活性相关性研究
Willias Masocha,Mohammed A Khedr
Willias Masocha
Monoacylglycerol lipase (MAGL) degrades the endocannabinoid 2-arachidonyl glycerol. MAGL inhibitors, such as the triterpene pristimerin, alleviate neuropathic pain in animal models. In silico studies were carried out using SwissDock, PyRx-0...
TGF-β-Enriched Exosomes from Acute Myeloid Leukemia Activate Smad2/3-MMP2 and ERK1/2 Signaling to Promote Leukemic Cell Proliferation, Migration, and Immune Modulation [0.03%]
富含TGF-β的急性髓系白血病来源外泌体通过激活Smad2/3-MMP2和ERK1/2信号促进白血病细胞增殖、迁移及免疫调节
Jie Jia
Jie Jia
Exosomes are extracellular vesicles secreted by all cell types, transporting nucleic acids, proteins, lipids, and metabolites. They are known to influence tumor biology by modulating cellular proliferation, invasion, and apoptosis. In acute...
Distinct Transcriptomic Profile Underlying High CO2 and Ethylene-Induced Deastringency in 'Daebong' Persimmon Fruit [0.03%]
日本榅桲果实高二氧化碳和乙烯处理去涩作用的转录组学特征分析
Min Woo Baek,Se Min Chang,DoSu Park et al.
Min Woo Baek et al.
Astringent persimmons (Diospyros kaki Thunb.) require effective postharvest deastringency treatments due to their high soluble tannin content at harvest. While high CO2 and ethylene are commonly used to remove astringency, their different e...
Exploring the Complete Chloroplast Genome of Pyrola decorata Andres: Structure, Variability, Phylogenetic Relationship [0.03%]
蒲儿菊.decorata andres完整叶绿体基因组：结构、变异和系统发育关系
Rong Kang,Shuai Kang,Kunzi Yu et al.
Rong Kang et al.
Pyrola decorata Andres (P. decorata) is a traditional medicinal plant in China. However, its chloroplast genome and the deep evolutionary relationships among its genus remain unexplored. This study identified the samples as P. decorata usin...
The Molecular Mechanism of Craniofacial Cartilage Deformity Induced by High Glucose in Zebrafish [0.03%]
高糖诱导斑马鱼颅面软骨畸形的分子机制研究
Xiaomei Chen,Yong Huang,Xin Yang et al.
Xiaomei Chen et al.
Gestational diabetes mellitus (GDM), a prevalent metabolic disorder in pregnancy, induces maternal hyperglycemia and elevates fetal malformation risks, particularly in craniofacial development. To investigate the underlying mechanisms, we e...