Necrostatin-1 Synergizes the Pan Caspase Inhibitor to Attenuate Lung Injury Induced by Ischemia Reperfusion in Rats [0.03%]
Necrostatin-1与泛半胱天冬酶抑制剂协同减轻大鼠缺血再灌注肺损伤
Liangrong Wang,Baihui Chen,Xiangqing Xiong et al.
Liangrong Wang et al.
Background: Both apoptosis and necroptosis have been recognized to be involved in ischemia reperfusion-induced lung injury. We aimed to compare the efficacies of therapies targeting necroptosis and apoptosis and to determ...
Serum and Cerebrospinal Fluid Cytokine Biomarkers for Diagnosis of Multiple Sclerosis [0.03%]
用于诊断多发性硬化的血清和脑脊液细胞因子生物标志物
Ekaterina Martynova,Mehendi Goyal,Shikhar Johri et al.
Ekaterina Martynova et al.
Background: Multiple sclerosis (MS) is a chronic debilitating disorder characterized by persisting damage to the brain caused by autoreactive leukocytes. Leukocyte activation is regulated by cytokines, which are readily d...
Expression of AIM2 in Rheumatoid Arthritis and Its Role on Fibroblast-Like Synoviocytes [0.03%]
AIM2在类风湿关节炎中的表达及其对滑膜纤维细胞样增生细胞的作用研究
Yong Chen,Qiu Fujuan,Ensheng Chen et al.
Yong Chen et al.
Objectives: To determine differences in AIM2 inflammasome expression levels between rheumatoid arthritis (RA) and osteoarthritis (OA) and to investigate the role of AIM2 in RA fibroblast-like synoviocytes (RA-FLS). ...
Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway [0.03%]
CD137信号通过增加VEGFA分泌和VEGFR2/Akt/eNOS通路促进出芽血管生成
Bo Li,Yue Zhang,Runting Yin et al.
Bo Li et al.
Combination of antiangiogenesis and immunotherapy may be an effective strategy for treatment of solid tumors. Our previous work reported that activation of CD137 signaling promotes intraplaque angiogenesis. A number of studies have demonstr...
Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 Diabetic Population [0.03%]
中国2型糖尿病患者循环Omentin-1与骨质疏松症的关系
Pijun Yan,Yong Xu,Zhihong Zhang et al.
Pijun Yan et al.
Aims: Omentin-1, a newly identified adipokine, has been demonstrated to be associated with bone metabolism, but the results have been inconsistent. Moreover, the potential relationship of circulating omentin-1 with diabet...
Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations [0.03%]
血红蛋白S病中转化生长因子β受体3的单倍型与脂质谱和临床表现相关
Rayra P Santiago,Camylla V B Figueiredo,Luciana M Fiuza et al.
Rayra P Santiago et al.
Individuals with sickle cell disease (SCD) present both chronic and acute inflammatory events. The TGF-β pathway is known to play a role in immune response, angiogenesis, inflammation, hematopoiesis, vascular inflammation, and cell prolife...
Hypertryptasemia and Mast Cell-Related Disorders in Severe Osteoporotic Patients [0.03%]
重度骨质疏松症患者的血清素水平和 mast cell 相关紊乱之间的关系
Giulia Carosi,Gregorio Guabello,Matteo Longhi et al.
Giulia Carosi et al.
Purpose: Systemic mastocytosis (SM) is characterized by a clonal proliferation of neoplastic mast cells (MCs) in one or more extracutaneous organs including the bone marrow (BM). SM is often associated with osteoporosis (...
Evaluating the Relationship of GDF-15 with Clinical Characteristics, Cardinal Features, and Survival in Multiple Myeloma [0.03%]
评估GDF-15与多发性骨髓瘤临床特征、主要特点和生存率的关系
Małgorzata Banaszkiewicz,Jolanta Małyszko,Krzysztof Batko et al.
Małgorzata Banaszkiewicz et al.
Growth differentiation factor 15 (GDF-15), a member of the transforming growth factor-β superfamily, participates in processes associated with myeloma development and its end-organ complications. It plays a significant role in both physiol...
Characterization of Synovial Cytokine Patterns in Bucket-Handle and Posterior Horn Meniscal Tears [0.03%]
半月板桶状和后角撕裂的滑膜细胞因子模式特征分析
Marco Turati,Davide Maggioni,Nicolò Zanchi et al.
Marco Turati et al.
The specific etiology of meniscal tears, including the mechanism of lesion, location, and orientation, is considered for its contribution to subsequent joint cytokine responsiveness, healing outcomes, and by extension, appropriate lesion-sp...
Molecularly Distinct NLRP3 Inducers Mediate Diverse Ratios of Interleukin-1 β and Interleukin-18 from Human Monocytes [0.03%]
不同分子的NLRP3诱导剂调节人类单核细胞产生的白介素-1β和白介素-18的比例
Kristine Midtbö,Daniel Eklund,Eva Särndahl et al.
Kristine Midtbö et al.
Inflammasomes cleave and activate interleukin- (IL-) 1β and IL-18 which have both shared and unique biological functions. IL-1β is an important mediator of the acute phase response to infections and tissue damage, whereas IL-18 takes part...