Bidirectional Regulation of NLRP3 Inflammasome and Mitochondrial Quality Control in Sepsis: Mechanisms and Therapeutic Implications [0.03%]
脓毒症中NLRP3炎性小体和线粒体质量控制的双向调节：机制与治疗意义
Xiangxin Liao,Yixun Wang,Zhaohui Zhang et al.
Xiangxin Liao et al.
Characterized by its capacity to induce organ failure, sepsis constitutes a life-threatening pathological state with high incidence and mortality rates. Current treatments primarily focus on antimicrobial therapy and organ support, lacking ...
FT3 Levels and Systemic Inflammation: Evidence From a Population-Based NHANES Analysis [0.03%]
FT3水平与全身性炎症：来自基于人口的NHANES分析的证据
Liu Yang,Han-Yu Wang,Meng-Fei Fu et al.
Liu Yang et al.
Objective: Previous studies suggest a complex interaction between 3,3',5-triiodo-L-thyronine (T3) and inflammation, but this relationship remains unclear. This study investigates the association between free triiodothyron...
Research Progress on Salvia miltiorrhiza Bioactive Components Regulating P-Selectin for Microcirculatory Improvement: Potential Implications in Acute Pancreatitis [0.03%]
茋类化合物调节P-选择素改善微循环研究进展及急性胰腺炎潜在治疗作用探讨
Yali Liu,Xinyi Ao,Weian Hao et al.
Yali Liu et al.
Severe acute pancreatitis (SAP) is associated with high morbidity and mortality. Microcirculatory dysfunction is a critical pathological event in this process and a primary contributor to organ failure (OF). Despite the pivotal role of P-se...
After Traumatic Brain Injury, EPHA4 Enhances Endoplasmic Reticulum Stress to Promote M1 Microglial Polarization Through the MAPK Signaling Pathway [0.03%]
EPHA4通过MAPK信号通路增强内质网应激促进小胶质细胞向M1表型极化以加重创伤性脑损伤后的炎症反应
Yang Tan,Jing Xia,Mingwei Liu et al.
Yang Tan et al.
Background: Traumatic brain injury (TBI) is an important cause of disability and death worldwide. The development of neuroinflammation after TBI is related to the brain parenchyma. M1-type microglia play important roles i...
Nicotine Regulates LPS-Induced Inflammatory Responses in HMC3 Microglia and Exerts Neuronal Protection [0.03%]
尼古丁通过调控LPS诱导的HMC3小胶质细胞炎症反应发挥神经保护作用
Yuhan Qin,Xiaohui Yan,Yanbo Luo et al.
Yuhan Qin et al.
Microglia-mediated neuroimmune responses have been implicated in central nervous system injury and disease pathogenesis. The α7 nicotinic acetylcholine receptor (α7 nAChR), which is expressed on microglia and participates in microenvironm...
Association Between Atopic Dermatitis and Systemic Immune-Inflammation Index: Evidence From NHANES 1999-2006 [0.03%]
国家健康和营养检查调查（1999-2006）中特应性皮炎与全身免疫炎症指数之间的关联证据
Jie Han,Ge Du,Shuping Guo et al.
Jie Han et al.
Background: Clinical studies have demonstrated that the systemic immune-inflammation index (SII) is widely used to assess immunity and inflammation in patients. However, the association between SII and atopic dermatitis (...
Robinia pseudoacacia L. Flower Exosome-Like Nanoparticles (RFELNs) Activate AhR/IL-22 to Relieve Intestinal Barrier Dysfunction Through Regulating Gut Microbiota-Interrelated Tryptophan Metabolism in Ulcerative Colitis Mice [0.03%]
黄芪花类外泌体纳米颗粒通过调节肠道菌群相关色氨酸代谢激活芳烃受体/IL-22缓解溃疡性结肠炎小鼠的肠道屏障功能障碍
Feihan Shen,Kewen Sun,Jianguo Song et al.
Feihan Shen et al.
Background: Intestinal barrier dysfunction is a key driver of ulcerative colitis (UC) recurrence and chronic persistence. Modulating group 3 innate lymphoid cells (ILC3) activity and tryptophan-derived metabolites is cruc...
Synergistic Alleviation of Inflammatory Cytokine Storms in Sepsis Rats by Low-Intensity Pulsed Ultrasound and Imipenem [0.03%]
低强度脉冲超声联合亚胺培南协同缓解脓毒症大鼠炎症细胞因子风暴作用及机制研究
Wentao Tang,Juan Deng,Xinyi Zhang et al.
Wentao Tang et al.
Aims: This study aimed to investigate the effects of low intensity pulsed ultrasound (LIPUS) combined with imipenem (IMI) on inflammatory responses and organ protection in septic rats. ...
Association Between Neutrophil Percentage-Albumin Ratio and Biological Aging in Rheumatoid Arthritis in the United States: A Cross-Sectional Study of NHANES [0.03%]
美国类风湿关节炎患者中性粒细胞百分比-白蛋白比率与生物衰老之间的关联：一项基于NHANES的横断面研究
Yangyu Xu,Hong Zhao,Yuxiang Gao et al.
Yangyu Xu et al.
Background: The accelerating process of global aging has made the burden of age-related diseases increasingly severe, and traditional chronological age fails to reflect individual heterogeneity in aging. The neutrophil pe...
Decoy Receptors in Autoimmunity: Molecular Guardians and Pathogenic Players in Immune Dysregulation [0.03%]
诱饵受体在自身免疫中的作用：免疫调节紊乱中的分子监护者和病理性参与者
Hadiseh Farahani,Parviz Kokhaei,Ali Ganji et al.
Hadiseh Farahani et al.
Autoimmune disorders encompass a varied range of diseases in which the immune system mistakenly targets and attacks the body's own tissues. The causes of the conditions are unknown. It is presumed that various genetic, environmental, and im...