Spatiotemporal Heterogeneity of Macrophages in Acute Pancreatitis: From Inflammatory Initiators to Repair Coordinators and Targeted Therapeutics [0.03%]
急性胰腺炎中巨噬细胞的时空异质性：从炎症启动者到修复协调者的靶向治疗
Xiang Lu,Yu Zeng,Li-Hong Gan et al.
Xiang Lu et al.
The current management of acute pancreatitis (AP) primarily relies on supportive measures, such as fluid resuscitation, nutritional support, and infection control. However, these approaches do not adequately address the core drivers of the ...
Biomarkers From the Microbiome to Predict ALD Progression and Its Severity: A Comprehensive Review [0.03%]
从微生物组中预测ALD进展及其严重程度的生物标志物：全面综述
Suraj Mishra,Harshrajsinh Solanki,Palash Mandal
Suraj Mishra
Alcohol use is a major global health issue, causing about 3.3 million deaths each year, or roughly 5.9% of all deaths worldwide. Alcohol-related liver disease develops in stages: steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatoce...
Nonlinear Relationship Between Lactate/Albumin Ratio and 28-Day ICU Mortality in Patients With Congestive Heart Failure: Insights Into Inflammatory and Metabolic Interplay [0.03%]
乳酸/白蛋白比值与心力衰竭患者的ICU 28天死亡率之间的非线性关系：炎症和代谢相互作用的启示
Yitong Bian,Ling Wang,Juan Ma et al.
Yitong Bian et al.
Background: Congestive heart failure (CHF) among critically ill patients is a significant cardiovascular disorder that is linked to elevated mortality rates. The lactate/albumin ratio (LAR) is a readily available clinical...
Integrative Inflammation-Metabolism Indicator for Cardiovascular-Kidney-Metabolic Syndrome: Evaluating the C-Reactive Protein-Triglyceride Glucose Index for Risk Stratification and Progression Across Three National Cohorts [0.03%]
心血管-肾脏-代谢综合征的炎症代谢综合指标：在三个全国队列中评估C反应蛋白-甘油三酯血糖指数的风险分层和进展状况
Yupeng Zeng,Huhao Feng,Haiying Cheng et al.
Yupeng Zeng et al.
Background: Inflammation plays a critical role in the onset and progression of cardiovascular-kidney-metabolic (CKM) syndrome. However, the optimal inflammatory biomarker that simultaneously reflects disease severity and ...
Tubal Patency Decoction and Its Ingredient β-Sitosterol Alleviate Tubal Infertility by Inhibiting Inflammation and Promoting Cilia Formation Through PGR [0.03%]
输卵管通液方及其成分β-谷甾醇通过PGR抑炎促纤毛形成改善输卵管性不孕效力的研究
Liang Shao,Nansu Wang,Yan Yan et al.
Liang Shao et al.
Background: Tubal infertility is one of the major causes of female infertility. This study aimed to investigate the mechanism of action of tubal patency decoction (TPD) and its active ingredient β-sitosterol on tubal inf...
Prognostic Value of the Neutrophil-to-Lymphocyte Ratio for All-Cause Mortality in Patients With Cardiovascular-Kidney-Metabolic Stage 4 [0.03%]
心血管-肾脏-代谢性疾病4期患者的全因死亡率的中性粒细胞淋巴比值预后价值
Longzhou Chen,Wencai Jiang,Guangrong Zhang et al.
Longzhou Chen et al.
Background: Cardiovascular-kidney-metabolic (CKM) Stage 4 is defined by established cardiovascular disease in the setting of kidney and/or metabolic dysfunction. Despite the high risk carried by this condition, simple too...
Macrophage-Driven Bidirectional Exacerbation in Psoriasis-Atherosclerosis Comorbidity: Insights From a Novel Mouse Model [0.03%]
小鼠模型揭示的银屑病-动脉粥样硬化共病双向加重的巨噬细胞机制
Fangshun Tan,Yu Jiang,Ruizhi Wang et al.
Fangshun Tan et al.
Background: Psoriasis (PSO) and atherosclerosis (AS) are chronic inflammatory diseases that frequently coexist, with each condition exacerbating the other. However, the underlying mechanisms remain poorly understood, part...
Multiomics Profiling Identifies Tlr4 as a Therapeutic Target of Necroptosis in Spinal Cord Injury [0.03%]
多组学分析鉴定TLR4为脊髓损伤中坏死性凋亡的治疗靶点
Wanzhou Wang,Lu Sun,Wei Xie et al.
Wanzhou Wang et al.
Spinal cord injury (SCI) leads to a complex cascade of cellular events, among which necroptosis plays a critical role in exacerbating neuronal injury and inflammation. In this study, we aimed to identify and validate key genes associated wi...
Geniposide Alleviates Inflammatory Bowel Disease by Regulating Intestinal Flora and Arginine Metabolism and Inhibiting the NF-κB Pathway Through Targeting Anxa5 [0.03%]
金丝桃苷通过靶向Anxa5调节肠道菌群和鸟氨酸代谢并抑制NF-κB信号通路从而缓解炎症性肠病
Xiu Wang,Francis Atim Akanyibah,Pengfei Zhang et al.
Xiu Wang et al.
Background: Inflammatory bowel disease (IBD), including Crohn's and ulcerative colitis (UC), is a chronic gut inflammation thought to be caused by gut microbial causes and immune system dysfunction. Geniposide (GEN) is a ...
Yangxin Tongluo Decoction Protects Against Sepsis-Associated Cardiac Dysfunction Through Regulating Nrf2 Pathway [0.03%]
养心通络汤通过调节Nrf2信号途径对抗脓毒症相关的心脏功能障碍
Hainan Yang,Beijing Wu,Die Huang et al.
Hainan Yang et al.
Background: Sepsis-induced cardiac dysfunction is a major cause of high mortality in critically ill patients. Yangxin Tongluo decoction (YXTLD), a traditional Chinese medicine (TCM) formula, is clinically used for such co...