A Machine Learning-Derived Taurine Metabolism Signature Predicts Prognosis and Immune Landscape in Lung Adenocarcinoma via Integrative Single-Cell Analysis [0.03%]
基于机器学习的牛磺酸代谢特征预测肺癌腺癌预后和免疫图谱整合单细胞分析
Meng Wang,Qiuqiao Mu,Yuhang Jiang et al.
Meng Wang et al.
Background: Lung adenocarcinoma (LUAD) represents a biologically diverse tumor type, often associated with unfavorable prognosis and unsatisfactory therapeutic outcomes. Over the past few years, increasing attention has b...
Causal Gene Identification and Biomarker Prioritization in Periodontitis via Integrative Multiomics and Mendelian Randomization [0.03%]
整合多组学和孟德尔随机化在牙周病的因果基因鉴定及生物标志物优先级划分中的应用
Haokun Mo,Lulu Chen,Shanshan Ren et al.
Haokun Mo et al.
Introduction: Periodontitis is a common inflammatory disease that compromises oral and systemic health. This study aimed to elucidate its molecular mechanisms and identify potential biomarkers for early diagnosis and prec...
The Impact of the hsCRP/BMI Ratio on Cardiovascular Outcomes in CAD Patients: A Population-Based Study [0.03%]
hsCRP/BMI比值对冠心病患者心血管预后影响的队列研究
Da Liu,Xuliang Wang,Kuo Zhang et al.
Da Liu et al.
Background: It remains uncertain whether a novel composite indicator, the high sensitivity C-reactive protein (CRP) (hsCRP)-to-body mass index (BMI) ratio (CBR), is associated with unfavourable events in subjects who have...
Role of Dendritic Cells in Mediating the Effect of Growth Differentiation Factor 15 on Nonalcoholic Fatty Liver Disease: Insights From Causal Inference and Single-Cell Profiling [0.03%]
生长分化因子15通过树突状细胞介导非酒精性脂肪肝病的作用机制：因果推断和单细胞谱系示踪的见解
Tao Yao,Peng Zheng,Zhe-Ning Wang et al.
Tao Yao et al.
Background: Nonalcoholic fatty liver disease (NAFLD) represents one of the most prevalent chronic liver conditions worldwide. Previous studies have highlighted an association between circulating growth differentiation fac...
Gut Microbes Secretions May Trigger Mononuclear Cell Migration and Offer Comorbidity Mechanism Between Inflammatory Bowel Disease and Diabetic Retinopathy [0.03%]
肠道微生物分泌物可能触发单核细胞迁移并提供炎症性肠病和糖尿病视网膜病变共病机制
Bingyu Xu,Shuduan Wu,Junfei Huang et al.
Bingyu Xu et al.
Background: Researches have found that the gut microbiota stimulate inflammation by releasing proinflammatory chemicals, including bile acids (BAs) and L-kynurenine. In the present study, our purpose is to investigate the...
Alleviation of Inflammatory Conditions Caused by Extremely Low-Frequency Electromagnetic Field Exposure by Panax ginseng [0.03%]
电磁场导致的炎症反应被人参缓解的作用及机制研究
Jee Yeon Choi,Ji Soo Lee,Seo An Lee et al.
Jee Yeon Choi et al.
Background: Electronic devices such as cellphones, microwaves, and other household devices are known to emit electromagnetic waves. As such, it creates an environment that may disrupt homeostasis. Ginsenosides in red gins...
Velutin Inhibits IL-1β-Induced Nucleus Pulposus Inflammatory and Extracellular Matrix Degradation Attenuating Mouse Intervertebral Disc Degeneration via the NF-κB and MAPK Pathways [0.03%]
.velutin通过NF-κB和MAPK途径抑制IL-1β诱导的髓核炎症和细胞外基质降解以缓解小鼠椎间盘退变
Yufeng Zhang,Rongjian Xu,Kelei Wang et al.
Yufeng Zhang et al.
Intervertebral disk degeneration (IVDD) usually causes lower back pain (LBP). Mechanical stress, trauma, aseptic inflammation, infection, and genetic susceptibility can accelerate the development of IVDD. Reportedly, proinflammatory cytokin...
Lipopolysaccharide Sensitizes Steroid-Induced Brain Injury in Neonatal Rat Pups [0.03%]
脂多糖增强内皮祖细胞向氧合损伤的迁移及促血管新生作用减弱
Yu-Shan Chang,Tzu-Mo Yang,Yu-Ling Hsu et al.
Yu-Shan Chang et al.
Background: Infection is a pathogenetic factor for bronchopulmonary dysplasia (BPD), and corticosteroids are often used for its prevention or treatment. However, few studies have examined their combined effects on brain i...
The Systemic Inflammation Response Index as an Independent Predictor of Acute Kidney Injury in Critically Ill Patients With Acute Myocardial Infarction: Insights From a Large-Scale Cohort Study [0.03%]
全身性炎症反应指数可独立预测急性心肌梗死重症患者的急性肾损伤：一项大规模队列研究的启示
Xudong Li,Liang Ruan,Shuyuan Zhang et al.
Xudong Li et al.
Background: Acute kidney injury (AKI) is a critical risk factor for adverse outcomes in acute myocardial infarction (AMI) patients admitted to the intensive care unit (ICU). Early identification of high-risk patients is e...
Research on the Antiaging Activity of Licorice Water Extract in Aging Mice via Antioxidation, Neuronal Protection, Gut Microbiota Restoration, and PI3K/AKT/mTOR Modulation [0.03%]
抗氧化、神经保护、肠道菌群重塑及PI3K/AKT/mTOR信号途径调节介导的甘草水提物抗衰老作用研究
Yanhua Yu,Baiji Xue,Tong Liu et al.
Yanhua Yu et al.
Background: Aging is a multifaceted physiological process characterized by progressive multiorgan dysfunction, oxidative stress, neuronal injury, cognitive impairment, and alterations in gut microbiota composition. Licori...