Association of Albumin-Bilirubin (ALBI) Grade With 28-Day All-Cause Mortality in Patients With Acute Respiratory Distress Syndrome: A Retrospective Analysis of the MIMIC-IV Database [0.03%]
急性呼吸窘迫综合征患者急性期ALBI分级与28天全因死亡率相关性研究：一项基于MIMIC-IV数据库的回顾性分析
Weixiao Chen,Qingzhou Chen,Zhiwei Tang et al.
Weixiao Chen et al.
The albumin-bilirubin (ALBI) grade, a validated prognostic tool in cancers such as hepatocellular carcinoma, has not been evaluated in acute respiratory distress syndrome (ARDS). This retrospective cohort study, utilizing data from the MIMI...
Integrating GEO Database, Mendelian Randomization, and Molecular Docking to Identify HLA-C as a Potential Therapeutic Target for Periodontitis [0.03%]
整合GEO数据库、孟德尔随机化和分子对接以确定HLA-C作为牙周炎潜在治疗靶点
ChengJi Shi,Xinyi Ou,LiJuan Huang et al.
ChengJi Shi et al.
Background: Periodontitis is a chronic inflammatory disease that leads to the destruction of periodontal tissues, ultimately resulting in tooth loss. Current treatments primarily focus on mitigating inflammation and alleviating symptoms, bu...
HMGB1 Exacerbates Intestinal Barrier Damage by Inducing Ferroptosis Through the TLR4/NF-κB/GPX4 Pathway in Ulcerative Colitis [0.03%]
HMGB1通过TLR4/NF-κB/GPX4信号通路诱导铁死亡从而加重溃疡性结肠炎肠道屏障损害
Nannan Zhu,Xiaoyuan Ge,Lixue Zhang et al.
Nannan Zhu et al.
Background: Intestinal barrier dysfunction and persistent inflammatory response are key pathophysiologic features of ulcerative colitis (UC). High mobility group box-1 protein (HMGB1), an important inflammatory mediator and immunomodulatory...
Orphan Class A GPCRs Signature Predicts Prognosis and Immune Microenvironment in Gastric Cancer: GPR176 Drives Tumor Progression Through Wnt Signaling and Macrophage Polarization [0.03%]
孤儿A类GPCR标志物预测胃癌的预后和免疫微环境：GPR176通过Wnt信号传导和巨噬细胞极化驱动肿瘤进展
Jiahui Lin,Lingling Ke,Sha Cheng et al.
Jiahui Lin et al.
Background: Orphan class A G protein-coupled receptors (GPCRs) are a large and diverse family with broad tissue expression, and their roles in tumors are increasingly recognized. However, their involvement in gastric cancer (GC) remains unc...
Jiren Wang,Xinwen Chen,Youli Ke et al.
Jiren Wang et al.
Background: Low-density granulocytes (LDGs), a unique subset of neutrophils, have been shown in previous studies to exhibit distinct biological functions in immune-inflammatory diseases. However, their role in acute pancreatitis (AP) remain...
Phytochemical Screening and In Vitro Antioxidant and Anticancer Evaluation of Stem and Leaf Extracts of Cissampelos pareira L [0.03%]
拉米尔氏铁棒藤茎叶部位的体外抗氧化及抗肿瘤活性研究
Arthid Thim-Uam,Chutamas Thepmalee,Wittaya Chaiwangyen et al.
Arthid Thim-Uam et al.
This study was conducted to investigate the phytochemical constituents, antioxidant capacity, and anticancer potential of aqueous, ethanolic, and hexane extracts derived from the leaves and stems of Cissampelos pareira L. (C. pareira L.). P...
Lymphocyte-to-Monocyte Ratio and All-Cause Mortality in Populations With Abdominal Aortic Calcification: A Prospective Cohort Study [0.03%]
腹部主动脉钙化人群的淋巴细胞与单核细胞比值与全因死亡率的关系：一项前瞻性队列研究
Jingjing Huang,Chunyong Chen
Jingjing Huang
Objective: The identification of reliable prognostic markers is essential for the effective management of abdominal aortic calcification (AAC). This research focused on assessing whether the lymphocyte-to-monocyte ratio (LMR) correlates wit...
Development of a Starvation Response-Based Model and Its Application in Prognostic Assessment of Liver Hepatocellular Carcinoma [0.03%]
基于营养不良反应模型的开发及其在肝细胞癌预后评估中的应用
Xinjun Hu,Yafeng Liu,Shujun Zhang et al.
Xinjun Hu et al.
Background: Hepatocellular carcinoma (LIHC) is a highly prevalent and poorly prognostic malignancy worldwide, and nutrient deprivation in the tumor microenvironment activates the starvation response in tumor cells. Starvation response-relat...
Evaluation of Gene Expression and the Regulatory Role of microRNAs Related to the Mitogen-Activated Protein Kinase Signaling Pathway in Human Retinal Pigment Epithelial Cells Treated With Lipopolysaccharide A and Tacrolimus [0.03%]
评估LPS A和他克莫司处理的人视网膜色素上皮细胞中与MAPK信号通路相关的基因表达及microRNAs的调控作用
Aleksandra Kiełbasińska,Katarzyna Krysik,Dominika Janiszewska-Bil et al.
Aleksandra Kiełbasińska et al.
Background: The retinal pigment epithelium (RPE) is central to retinal health and immune regulation. In diseases, such as proliferative vitreoretinopathy (PVR), dysregulated RPE function, driven by aberrant signaling pathways like mitogen-a...
Association Between Dietary Inflammatory Index and NAFLD: A Cross-Sectional Study of the National Health and Nutrition Examination Survey [0.03%]
膳食炎症指数与非酒精性脂肪肝的关系：全国健康和营养调查的横断面研究
Yuan He,Yuhang Yang,Pengfei Cheng et al.
Yuan He et al.
Background and Aim: The aim of this study was to determine if there is an association between the dietary inflammatory index (DII) and nonalcoholic fatty liver disease (NAFLD). Methods: Study data were obtained from the National Health and ...