TUG1 and H19 lncRNAs Can Predict Anti-TNF Unresponsiveness in Patients With Ulcerative Colitis: A Machine Learning-Based Approach [0.03%]
基于机器学习的方法预测溃疡性结肠炎患者抗TNF应答不良：TUG1和H19长链非编码RNA可作为新的生物标志物
Raheleh Heydari,Mohammad Javad Tavassolifar,Mohammad Hossein Derakhshan Nazari et al.
Raheleh Heydari et al.
The present study aimed to explore the association of long noncoding RNAs (lncRNAs) with inflammation, disease activity, and predicting response to anti-tumor necrosis factor (TNF)-α therapy in patients with ulcerative colitis (UC). Whole ...
SNHG5 Exacerbates Sepsis-Induced Inflammatory Injury in Coronary Artery Endothelial Cells by Regulating METAP2-Mediated IL-8 Secretion [0.03%]
SNHG5通过调控METAP2介导的IL-8分泌加剧脓毒症诱导的冠状动脉内皮细胞炎症损伤
Tingzhi Deng,Ding Li,Lihui Liang et al.
Tingzhi Deng et al.
Background: Long noncoding RNAs (lncRNAs) are involved in regulating inflammatory responses in sepsis. This study aimed to investigate the potential roles of lncRNA SNHG5 in the pathogenesis of sepsis-induced coronary art...
Imidazole Propionate Induces Kidney Damage by Activating the ROS-NLRP3 Signaling Pathway Through mTOR Inhibition of Autophagy in Renal Tubular Epithelial Cells [0.03%]
咪唑乙酸通过mTOR抑制自噬激活ROS-NLRP3信号途径诱导肾小管上皮细胞损伤导致肾脏损害
Chen Zeng,Yu-Ru Xiao,Si-Qing Li et al.
Chen Zeng et al.
L-Histidine, a parent structure of environmental contaminants (e.g., pesticides and preservatives), may undergo bioaccumulation through the food chain and be metabolized by the gut microbiota into deleterious compounds, ultimately compromis...
Benzydamine Attenuates Matrix Metalloproteinase-9 Expression Through Inhibition of ERK MAPK in Activated Human Monocytic Cells Under Hyperglycemic Condition [0.03%]
苯扎明通过抑制ERK-MAPK通路减少高糖条件下活化的人单核细胞 MMP-9 的表达
Anh Phong Do,Yan-Cheng Shen,Yu-Wen Cheng et al.
Anh Phong Do et al.
Much evidence has demonstrated that the association between sepsis and diabetes can result in comorbidity effects. The endotoxin lipopolysaccharide (LPS) is a damaging factor that penetrates through the intestinal wall and into circulation ...
Investigating the Relationships Among Gut Microbiota, Inflammatory Cytokines, Cerebrovascular Diseases, and the Mediation Pathways [0.03%]
肠道菌群、炎症因子、脑血管疾病及其作用途径的关系研究
Qi Li,Xinpeng Liu,Xiang Deng et al.
Qi Li et al.
Objectives: Cerebrovascular disease (CeVD), the second leading global cause of death, has an incompletely understood pathogenesis. This study aimed to investigate causal relationships among gut microbiota, inflammatory cy...
The Role of APOL1 in Necrotizing Enterocolitis and Its Promise as a Diagnostic Biomarker [0.03%]
APOL1在坏死性小肠结肠炎中的作用及其作为诊断生物标志物的潜力
Jie-Ting Lu,Qiu-Hua Wang,Ying-Yan Liu et al.
Jie-Ting Lu et al.
Objective: Necrotizing enterocolitis (NEC) is a severe inflammatory disease of the intestine. Although previous studies have demonstrated that APOL1 plays an important role in regulating macrophage polarization and immune...
Integrative Multi-Omics Identifies S100A4 as a Translational Hub Linking Environmental Bis(2-Ethylhexyl) Phthalate (DEHP) Exposure to Glioblastoma Risk [0.03%]
整合多组学分析识别出S100A4是介导环境增塑剂DEHP暴露与胶质母细胞瘤发病风险关联的枢纽蛋白
Shasha Tan,Zhou Li,Zhenjiang Du et al.
Shasha Tan et al.
Glioblastoma (GBM) is a highly aggressive central nervous system malignancy with a dismal 5-year survival rate of less than 5%, and poorly understood environmental factors complicate its treatment. One such factor is bis(2-ethylhexyl) phtha...
Targeting Pulmonary Hypertension: Elucidating Sophocarpine's Protective Role via Preclinical Models [0.03%]
靶向肺动脉高压：通过前期模型阐明Sophocarpine的保护作用
Feng Xie,Jie Feng,Kai Li et al.
Feng Xie et al.
Background: Pulmonary hypertension (PH) is a serious disease that manifests itself as elevated pressure within the pulmonary arteries. The onset of PH is usually insidious, and if left untreated, it may lead to heart fail...
Association Between Three Systemic Inflammatory Biomarkers and Diabetic Foot Ulcer: A Cross-Sectional Study and a Clinical Retrospective Study [0.03%]
三种系统性炎症生物标志物与糖尿病足溃疡的相关性：一项横断面研究和临床回顾性研究
Hua Chen,Yu Zhou,Jiezhi Dai
Hua Chen
Background: This study aimed to investigate the association between systemic inflammatory biomarkers-specifically the systemic inflammatory response index (SIRI), systemic immune inflammation index (SII), and aggregate in...
Association Between CBC-Derived Inflammatory Indicators and 28-Day Mortality in Patients With Coronary Heart Disease and Diabetes Mellitus: A Cohort Study From the MIMIC-IV Database [0.03%]
冠心病合并糖尿病患者炎症指标与28天死亡率相关性研究：来至MIMIC-IV数据库的队列研究
Guang Tu,Zhonglan Cai,Shengnan Xue et al.
Guang Tu et al.
Background: Coronary heart disease (CHD) remains the leading global cause of death; concomitant diabetes mellitus (DM) doubles short-term mortality, largely through chronic low-grade inflammation. Inexpensive, bedside com...