P-MAPA, a Fungi-Derived Immunomodulatory Compound, Induces a Proinflammatory Response in a Human Whole Blood Model [0.03%]
由真菌衍生的免疫调节化合物P-MAPA通过人类全血模型诱导促炎反应
Mariana Torrente Gonçalves,Carla Cristina Squaiella-Baptistão,Giselle Pidde et al.
Mariana Torrente Gonçalves et al.
P-MAPA is a complex compound, derived from Aspergillus oryzae cultures, that has shown immunomodulatory properties in infection and cancer animal models. Despite promising results in these models, the mechanisms of cellular activation by P-...
Lipoxin A4 Reduces Ventilator-Induced Lung Injury in Rats with Large-Volume Mechanical Ventilation [0.03%]
脂氧素A4减少大潮气量通气致肺损伤小鼠的呼吸机诱导性肺损伤
Qi Wang,Guang-Xiao Xu,Qi-Hang Tai et al.
Qi Wang et al.
Ventilator-induced lung injury (VILI) is a severe and inevitable complication in patients who require mechanical ventilation (MV) for respiratory support. Lipoxin A4 is an endogenous anti-inflammatory and antioxidant mediator. The present s...
Plasma Proteome Profiling of Coronary Artery Disease Patients: Downregulation of Transthyretin-An Important Event [0.03%]
冠心病患者血浆蛋白质组分析： transthyretin下调是一个重要事件
Monu,Rupsi Kharb,Ankita Sharma et al.
Monu et al.
Coronary artery disease (CAD) is a prevalent chronic inflammatory cardiac disorder. An early diagnosis is likely to help in the prevention and proper management of this disease. As the study of proteomics provides the potential markers for ...
Contribution of Connexin Hemichannels to the Pathogenesis of Acute Lung Injury [0.03%]
连接子半通道在急性肺损伤发病机制中的作用
Shuaiwei Wang,Yafang Sun,Yu Bai et al.
Shuaiwei Wang et al.
Connexin (Cx) family members form hemichannels (HCs) and gap junctions (GJs). Biological functions of Cx HCs have not been adequately characterized due to the inability to selectively target HCs or GJs. Recently, we developed a 6-mer peptid...
Changes in Peripheral Blood Neutrophils, Lymphocytes and IL-10 in Children with Kawasaki Disease from Different Age Groups Undergoing Intravenous Immunoglobulin: A Retrospective Study [0.03%]
不同年龄段川崎病患儿静脉注射免疫球蛋白前后外周血中性粒细胞、淋巴细胞及IL-10变化：一项回顾性研究
Chun Zhang,Xuan Zhang,Jia Shen et al.
Chun Zhang et al.
Immunoglobulin intravenous (IVIG) is widely used in mucocutaneous lymph node syndrome, known as Kawasaki disease (KD). However, the patients' inflammatory response during usage remains unclear. In the present study, the association between ...
The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative Resection [0.03%]
术前系统性免疫炎性指数变化可独立预测结直肠癌术后患者生存
Qingqing Chen,Haohao Wu,Xinwei Guo et al.
Qingqing Chen et al.
Background: The systemic immune-inflammation index (SII) has an important role in predicting survival in some solid tumors. However, little information is available concerning the change of the SII (∆SII) in colorectal c...
High Erythropoiesis Resistance Index Is a Significant Predictor of Cardiovascular and All-Cause Mortality in Chinese Maintenance Hemodialysis Patients [0.03%]
高红细胞生成抵抗力指数与中国维持性血液透析患者心血管事件和全因死亡风险增加相关
Xiangxue Lu,Jialing Zhang,Shixiang Wang et al.
Xiangxue Lu et al.
Background: Renal anemia is a common complication of hemodialysis patients. Erythropoietin (EPO) hyporesponsiveness has been recognized as an important factor to poor efficacy of recombinant human erythropoietin in the tr...
Immunometabolism, Micronutrients, and Bariatric Surgery: The Use of Transcriptomics and Microbiota-Targeted Therapies [0.03%]
免疫代谢、微量营养物质和减肥手术：转录组学和靶向微生物群疗法的应用
Shannon Galyean,Dhanashree Sawant,Andrew C Shin
Shannon Galyean
Background: Obesity is associated with the gut microbiota and decreased micronutrient status. Bariatric surgery is a recommended therapy for obesity. It can positively affect the composition of the gut bacteria but also d...
Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene Expression [0.03%]
基于人群的队列研究和体外肝脂质生成相关基因表达观察尿酸降低治疗对痛风患者血脂异常风险的影响
Yi-Jen Fang,Tien-Yuan Wu,Cheng-Li Lin et al.
Yi-Jen Fang et al.
Patients with gout are at a higher risk of cardiovascular disease, which is associated with hyperlipidemia. Management of gout in Taiwan is poor, and the association between urate-lowering therapy (ULT) among gout patients and hyperlipidemi...
Culturing Articular Cartilage Explants in the Presence of Autologous Adipose Tissue Modifies Their Inflammatory Response to Lipopolysaccharide [0.03%]
自身脂肪组织的存在下培养关节软骨标本改变其对内毒素的炎症反应
Wendy Pearson,Anna E N Garland,Ashley Nixon et al.
Wendy Pearson et al.
The purpose of the current study was to explore the effect of autologous adipose tissue on cartilage responses to lipopolysaccharide (LPS). We hypothesized that LPS elicits an inflammatory response in cartilage, and that response is augment...