Aster spathulifolius Maxim. Alleviates Primary Dysmenorrhea in a Mouse Model by Modulating Myometrial Contractions via NF-κB/COX-2 Pathway Inhibition [0.03%]
máxima亚麻叶铁线莲通过NF-κB/COX-2信号通路抑制调节子宫平滑肌收缩缓解小鼠原发性痛经
Min-Soo Kim,Kang-In Lee,Heung Joo Yuk et al.
Min-Soo Kim et al.
Primary dysmenorrhea (PD) is characterized by excessive uterine contraction and ischemic vasoconstriction, primarily driven by elevated levels of prostaglandins (PGs; PGF2α) and inflammatory mediators. Nonsteroidal antiinflammatory drugs (...
Gut Microbiota Dysbiosis in Preeclampsia: Mechanisms, Biomarkers, and Probiotic-Based Interventions [0.03%]
子痫前期的肠道微生态失衡：机制、生物标志物和益生菌干预
Yefang Zhao,Bingjie Wang,Xujing Wei et al.
Yefang Zhao et al.
Background: This study aimed to investigate the impact of fecal microbiota transplantation (FMT) on gut microbiota composition and serum inflammatory factors in a murine model. Methods: Female C57BL/6J mice (n = 60) were divided into four g...
Identification of Ifitm1 as a Pivotal Gene in Mouse Spinal Cord Injury Using Comprehensive Machine Learning Algorithms [0.03%]
使用全面的机器学习算法识别Ifitm1作为小鼠脊髓损伤中的关键基因
Yu Yao,Kun Xi,Shaohu Xu et al.
Yu Yao et al.
Background: Spinal cord injury (SCI) functions as a medical condition leading to substantial motor and neurological system deteriorations. Researchers must understand the molecular mechanisms of this disease because it serves as a foundatio...
Immunocytes Mediate the Effects of Gut Microbiome on Inflammatory Bowel Disease: Insights From a Mendelian Randomization Study [0.03%]
肠道微生物组对炎症性肠病的影响通过免疫细胞介导：一项孟德尔随机化研究的新见解
Linbin He,Jianhui Wei,Ziye Li et al.
Linbin He et al.
Observational evidence suggests a complex link between gut microbiota and inflammatory bowel disease (IBD). However, the mechanisms underlying this relationship remain unclear. The present Mendelian randomization (MR) study aims to examine ...
Impaired Meningeal Lymphatic Drainage Aggravates LPS-Induced Neuroinflammation and Depression-Like Behaviors in Mice [0.03%]
小鼠脑膜淋巴引流障碍加重LPS诱导的神经炎症和抑郁样行为
Chonglong Shi,Yin Zhou,Qiang Zhang et al.
Chonglong Shi et al.
Background: The role of meningeal lymphatic vessels (mLVs) in neurodegenerative diseases has been increasingly recognized. However, their involvement in lipopolysaccharide (LPS)-induced neuroinflammation and associated depression-like behav...
The Effect of Fentanyl Abuse on the Gut Microbiota Pattern, Inflammation, and Metabolic Alterations in a Fentanyl Dependance Rat Model [0.03%]
芬太尼依赖大鼠模型中芬太尼滥用对肠道菌群模式、炎症及代谢改变的影响研究
Kianoosh Ferdosnejad,Parvaneh Maghami,Mohammad-Reza Zarrindast et al.
Kianoosh Ferdosnejad et al.
Introduction: This study examines the effects of fentanyl misuse on gut microbiota, inflammation, and metabolic pathways using a rat model. As the opioid crisis, driven by synthetic opioids like fentanyl, escalates, identifying new biomarke...
Immunophenotyping of Patients With Rheumatoid Arthritis Reveals Difference in CD27+IgD+ Unswitched Memory B Cell Profiles [0.03%]
免疫分型发现类风湿关节炎患者CD27+IgD+未转换记忆B细胞谱型不同
Bérénice Hansen,Raul Da Costa,Dominique Revets et al.
Bérénice Hansen et al.
Objectives: Over the past decades, the prevalence of noncommunicable diseases has surged significantly, including the systemic autoimmune disorder rheumatoid arthritis (RA). Despite extensive research and advancement of RA therapy, effectiv...
Association of Inflammatory Factors and Calcium Metabolism With Arthritis in Patients With Inflammatory Bowel Disease: Evidence From Mediated Mendelian Randomization [0.03%]
基于中介孟德尔随机化在炎症性肠病患者中探究炎症因素和钙代谢与关节炎的关联：证据来自中介梅诺特随机化分析
Sinan Xiao,Kairong Su,Hongliang Gao et al.
Sinan Xiao et al.
Background: Beyond intestinal inflammation, inflammatory bowel disease (IBD) is associated with many extraintestinal manifestations, particularly arthritis. However, systematic evidence regarding causal relationships between IBD and clinica...
Determination of Serum Alpha-1-Acid Glycoprotein Concentration and the Influence of Physiological and Gynecological Factors in Women Attending in Tertiary-Care Center in Mexico: A Pilot Study [0.03%]
墨西哥三级医疗中心妇女血清α1酸性糖蛋白浓度的测定及其生理和妇科因素的影响：一项试点研究
Liliana García-Ortiz,Mariana Téllez-Araiza,José Gutiérrez-Salinas et al.
Liliana García-Ortiz et al.
Alpha 1-acid glycoprotein (AGP1) is recognized as a protein with an important immunomodulatory activity, which under certain circumstances its serum concentration is altered as a result of acute metabolic stress (e.g., infections) or chroni...
HBP21 Alleviates Sepsis-Induced Acute Kidney Injury by Targeting PI3K/AKT-Mediated M1 Macrophage Polarization [0.03%]
通过靶向PI3K/AKT介导的M1型巨噬细胞极化缓解HBP21所致脓毒症诱导的急性肾损伤
Na An,Mingzhi Xu,Ruman Chen et al.
Na An et al.
Background: Sepsis-induced acute kidney injury (S-AKI), a life-threatening complication of systemic infection, is driven by macrophage-mediated inflammatory dysregulation. This study explores the role of heat shock binding protein 21 (HBP21...