Miacalcic Enhances Rotator Cuff Injury Healing in Osteoporotic Mice by Stimulating Neovascularization via the JAK Pathway [0.03%]
MIACALCIC通过激活JAK途径促进新生血管化从而增强骨质疏松小鼠肩袖损伤的修复作用
Feng Mao,Jinguo Zhu,Xinting Feng et al.
Feng Mao et al.
Objective: Rotator cuff tears (RCT) are prevalent among the elderly and often lead to significant shoulder pain. While both open and arthroscopic cuff repairs are effective, the recurrence of RCT post-surgery remains high...
Urinary Polycyclic Aromatic Hydrocarbons and Advanced Cardiovascular-Kidney-Metabolic Syndrome: Inflammatory-Nutritional Pathways as Mediators [0.03%]
尿中多环芳烃与心血管-肾脏-代谢综合征：炎症-营养途径作为介导因素
Yifeng Huang,Youxia Zhao,Qizhang Man et al.
Yifeng Huang et al.
Background: Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants linked to adverse health outcomes. Their role in the different statuses of Cardiovascular-Kidney-Metabolic (CKM) syndrome remains...
Gut-Liver Axis Failure in Critical Alcohol-Associated Liver Disease: From ICU Secondary Hits to Microbiome-Targeted Therapy [0.03%]
重症酒精性肝病中的肠肝轴功能障碍：从ICU继发损伤到针对微生物组的治疗
Yuting Zhang,Yiyu Wang,Yong Yang et al.
Yuting Zhang et al.
Alcohol-associated liver disease (ALD) can progress to critical illness phenotypes requiring intensive care, including severe alcohol-associated hepatitis, acute decompensation, and alcohol-associated acute-on-chronic liver failure (ACLF). ...
Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSCs) and Small Intestinal Submucosa (SIS) Hydrogel Composite Can Meliorate TNBS-Induced Experimental Colitis Through Regulating Inhibiting Macrophage Polarization Toward the M1 Phenotype [0.03%]
骨髓来源间充质干细胞与小肠黏膜下层水凝胶复合物通过抑制巨噬细胞向M1表型极化来改善TNBS诱导的实验性结肠炎
Zikai Sun,Yan Zhou,Xiang Geng et al.
Zikai Sun et al.
An imbalance of macrophage polarization exerts influence over inflammatory bowel disease (IBD) pathogenesis. To investigate how macrophage polarization influences IBD, we engineered a composite system consisting of small intestinal submucos...
Targeting IL-17 Presents a Promising Strategy for Treating Diseases Related to the Dysregulation of Lipid Homeostasis [0.03%]
靶向IL-17可能是治疗脂质稳态失调相关疾病的有效策略
Chen Zhang,Yu-Yue Xue,Dian-Qun Ren et al.
Chen Zhang et al.
Lipids are fundamental constituents of cell membranes and play a crucial role in signaling pathways that regulate a wide array of cellular functions. Consequently, the dysregulation of lipid homeostasis is recognized as a significant contri...
Therapeutic Potential of Bee Venom and Capsicum annum Hydroethanolic Extract in Experimental Model of Rheumatoid Arthritis in Male Rats [0.03%]
实验模型中蜂毒和辣椒萃取物治疗类风湿性关节炎的潜力
Ahmed Hussain,Amira Sh Soliman,Mohamed Abd-Elbaset et al.
Ahmed Hussain et al.
Background: Rheumatoid arthritis (RA) is a long-term inflammatory disease linked to higher mortality, joint degeneration, and long-term disability. This study evaluated the anti-inflammatory, antioxidant, and immunomodula...
Inhibition of IL-17 Alleviates Blood-Brain Barrier Disruption Following Diffuse Axonal Injury Accompanied by Hyperglycemia Through the NF-κB Pathway [0.03%]
IL-17抑制通过NF-κB途径缓解伴发高血糖弥漫性轴索损伤后的血脑屏障破坏作用
Zhiguo Xing,Xing Wei,Ming Zhang et al.
Zhiguo Xing et al.
Objective: To clarify the effects and mechanism of interleukin-17A (IL-17) in hyperglycemia (HG)-induced blood-brain barrier (BBB) breakdown following diffuse axonal injury (DAI). ...
IL-6 Exacerbates Experimental Autoimmune Prostatitis by Disrupting STAT5a-Mediated Treg Cell Function and Th17/Treg Balance [0.03%]
白细胞介素6通过破坏STAT5a调节的Treg功能及Th17/Treg平衡从而加重实验性自身免疫前列腺炎
Xianhong Liu,Xiaokang Bian,Shanchuan Han et al.
Xianhong Liu et al.
Objective: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common urological condition in men. Although disruption of the Th17 (T helper 17)/Treg (regulatory T) balance has been implicated in its pathogene...
Role of BMEC-Derived Exosomal miR-144-3p in Microglial Polarization: Unveiling the NLRP3-GSDMD Pathway in Intracerebral Hemorrhage [0.03%]
脑内出血中BMEC来源的外泌体miR-144-3p在小胶质细胞活化中的作用及NLRP3-GSDMD信号通路的介导效应机制研究
Jun Ma,Zhongying Ran,Tao Luo et al.
Jun Ma et al.
Background: Intracerebral hemorrhage (ICH) often triggers a cascade of inflammatory responses, leading to secondary brain injury. The present work elucidated the regulatory mechanisms of NLRP3 inflammasome pathway activat...
Downregulation of Caveolin-2 Is a Novel Mechanism Involved in Activation of Inducible Nitric Oxide Synthase (iNOS) in Mouse Peritoneal Macrophages [0.03%]
小窝蛋白-2下调是参与激活小鼠腹腔巨噬细胞诱导型一氧化氮合成酶(iNOS)的一种新机制
Sungchan Jang,Grzegorz Sowa
Sungchan Jang
Here we report that membrane protein caveolin-2 (Cav-2) is regulated during activation of primary mouse peritoneal macrophages and RAW264.7 macrophage cell line by a bacterial lipopolysaccharide (LPS) and a cytokine, interferon gamma (IFN-...