Identification of Diagnostic Biomarkers for Myocardial Infarction Using Bioinformatics and Disulfidptosis-Targeted Computational Drug Discovery [0.03%]
基于生物信息学和二硫键靶向的计算药物发现的心肌梗死诊断生物标志物识别
Haoran Zhang,Ziguang Song,Weitao Shen et al.
Haoran Zhang et al.
Disulfidptosis, a newly discovered form of regulated cell death, is involved in multiple disease processes. This study applied computational methods to identify disulfidptosis-related genes in myocardial infarction (MI). Differentially expr...
Efficacy of Medicated Thread Moxibustion of Zhuang Medicine on Skin Lesions in Eczema Rats Based on p38/NF-κB and JAK1-STAT6 Pathways [0.03%]
基于p38/NF-κB和JAK1-STAT6信号通路的壮医药线灸治疗湿疹大鼠皮肤病变的疗效观察
Liangbing Wu,Jian Dai,Yongzheng Wei et al.
Liangbing Wu et al.
Objective: Eczema is a common inflammatory skin disease that severely affects patients' daily life and work, necessitating effective intervention. Medicated thread moxibustion of Zhuang medicine (MTMZM), an integral part of Chinese medicine...
Caffeine Acts as an Agonist of Siglec-6, Inhibits MRGPRX2-Triggered Mast Cell Degranulation and Anaphylactoid Reactions [0.03%]
咖啡因通过Siglec-6正向调控抑制MRGPRX2诱导的肥大细胞脱颗粒和非变态反应
Yuanyuan Ding,Na Wang,Chenrui Zhao et al.
Yuanyuan Ding et al.
Background: Mast cells (MCs) are effectors of anaphylactoid reactions. Mas-related G-protein-coupled receptor X2 (MRGPRX2) receptor mediates the direct activation of MCs in anaphylactoid disease. Siglec-6 negatively regulates MC activation ...
Electroacupuncture Attenuates Hepatic Ischemia-Reperfusion Injury by Modulating the Esr1/TAK1-JNK/p38 Signaling Pathway in Rats [0.03%]
电针通过调节雌激素受体1/TAK1-JNK/p38信号途径减轻大鼠肝脏缺血再灌注损伤
Xiaofang Fan,Wei Guo,Xiaodan Yang et al.
Xiaofang Fan et al.
Electroacupuncture (EA) has demonstrated protective effects against hepatic ischemia-reperfusion injury (HIRI) in rat models. This study aimed to explore the underlying molecular mechanisms by which EA exerts its protective effects against ...
Restoration of Immune Homeostasis: The Role of miR-30b-5p and Notch Signaling in Uveitis After Treatment With Longdan Xiegan Decoction [0.03%]
基于龙胆泻肝汤治疗的自身免疫性葡萄膜炎中miR-30b-5p和Notch信号通路对免疫稳态重塑的作用机制研究
Yan Qiu,Xuewei Yin,Lijie Guo et al.
Yan Qiu et al.
Uveitis is an inflammatory eye disease, and Longdan Xiegan Decoction (LXD) has been used to treat uveitis. However, the underlying mechanisms have not fully been addressed. The present study aimed to provide new insights into LXD ameliorati...
Multiomics Integration and Machine Learning Reveal Colony Stimulating Factor 3 Receptor as a Key Gene and Therapeutic Target in Crohn's Disease [0.03%]
多组学整合和机器学习揭示粒细胞集落刺激因子 3 受体是克罗恩病的关键基因和治疗靶点
Peihong Li,Hongyi Hu,Lujia Yang et al.
Peihong Li et al.
Crohn's disease (CD) is a chronic inflammatory disease characterized by complex immune dysregulation in which the identification of key molecular drivers is critical for the advancement of diagnostic and therapeutic approaches. In this stud...
Identification of Endoplasmic Reticulum Stress-Related Genes in Osteoporosis Pathogenesis [0.03%]
识别与骨质疏松发病机制相关的内质网应激相关基因
Yiren Zhu,Xiu Yang,Yunan Lu et al.
Yiren Zhu et al.
Background: Osteoporosis is a prevalent metabolic bone disorder with complex molecular underpinnings. Emerging evidence implicates endoplasmic reticulum stress (ERS) in its pathogenesis; however, systematic exploration of ERS-related genes ...
The Association Between Neutrophil-to-Lymphocyte Ratio, Atherogenic Index of Plasma, and Cardiovascular Disease Incidence [0.03%]
中性粒细胞与淋巴细胞比率、血浆致动脉粥样硬化指数与心血管病发病的关联分析
Hongxin Cheng,Wen Zhong,Hanbin Li et al.
Hongxin Cheng et al.
Background: With the incidence of cardiovascular disease (CVD) escalating annually, the significance of investigating the correlation between inflammatory markers and lipid-related indices, notably the neutrophil-to-lymphocyte ratio (NLR) a...
Sleep Patterns and Cardiovascular Disease Risk: Investigating the Mediating Role of Inflammatory Markers in a Large NHANES Adult Population [0.03%]
睡眠模式与心血管疾病风险：在大规模NHANES成人人群中探讨炎症标志物的中介作用
Xinru Guo,Shiting Mi,Lin Zhao et al.
Xinru Guo et al.
Purpose: Inflammation plays a central role in the occurrence and progression of cardiovascular disease (CVD). However, the intricate relationships between sleep patterns, inflammatory markers, and CVD risk remain insufficiently understood. ...
GPR34 Stabilized by Deubiquitinase USP8 Suppresses Ferroptosis of ATC [0.03%]
由去泛素化酶USP8稳定化的GPR34通过抑制铁死亡来抑制ATC进展
Bokang Yan,Jiaxing Guo,Meiyuan Huang et al.
Bokang Yan et al.
G protein-coupled receptor 34 (GPR34) is an orphan receptor within the G protein-coupled receptor (GPCR) superfamily, and its specific role in anaplastic thyroid carcinoma (ATC) remains to be elucidated. In this study, we observed that GPR3...