Integrating Single-Cell Transcriptomics and Mendelian Randomization to Identify RAC1 as a Causal Metabolic Driver of Pericyte Dysfunction in Systemic Sclerosis [0.03%]
整合单细胞转录组和孟德尔随机化鉴定RAC1为系统性硬化症周细胞功能障碍的代谢驱动因素
Xiaoqing Wang,Zheng Zhang,Enze Jiang et al.
Xiaoqing Wang et al.
Background: Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular injury and progressive fibrosis. Although microvascular injury is an inciting event and pericytes are recognized as a major source of...
Integrative Multiomics and Network Pharmacology Exploration of Active Components and Mechanisms of Action of Qufu Shengxin Ointment in Treating Chronic Nonhealing Wounds [0.03%]
曲佛生新软膏治疗慢性难愈性创面活性成分及作用机制的整合多组学与网络药理学探索
Haidong Chen,Yimei Li,Dexuan Chen et al.
Haidong Chen et al.
Background: Chronic nonhealing wounds (CNHWs) are characterized by persistent inflammation and impaired autophagy, which hinder normal wound repair. Qufu Shengxin Ointment (QFSO) has shown clinical benefits in treating ch...
Experimental Study of YaJieShaBa Antialcoholic Hepatic Fibrosis Through TGF-β1/Smad Signaling Pathway [0.03%]
雅解沙巴抗醇保肝作用的实验研究及其对TGF-β1/Smads信号转导通路的影响
Linao Zhang,Yuanmei Bai,Shifang Luo et al.
Linao Zhang et al.
Objective: This study aimed to clarify the pharmacodynamic effects of YaJieShaBa (YJSB) against alcoholic hepatic fibrosis (HF) and elucidate its mechanism in regulating the transforming growth factor-β1 (TGF-β1)/Smad p...
Immune Infiltration-Related Genes as Potential Biomarkers and Predicted Targets for Renal Allograft Delayed Graft Function and Survival Outcome: An Integrated Machine Learning Approach and Drugs Analysis [0.03%]
基于机器学习方法和药物分析整合的免疫浸润相关基因作为肾移植延迟移植物功能及预后的潜在生物标志物及预测靶点研究
Yifei Zhang,Yuqing Li,Xuemeng Qiu et al.
Yifei Zhang et al.
Background: Ischemia-reperfusion injury (IRI) significantly impacts post-kidney transplantation (KTx), leading to delayed graft function (DGF) and potential graft loss. Current biomarkers and therapies for DGF and graft s...
Myocarditis After mRNA Vaccination: A Metabolic-Innate Immune Cascade Centered on Lipid Nanoparticles [0.03%]
mRNA疫苗接种后心肌炎：以脂质纳米颗粒为中心的代谢-先天性免疫级联反应
Kangchan Choi,Seungchan Choi,Daeho Joe et al.
Kangchan Choi et al.
mRNA vaccine-associated myocarditis is a rare but clinically important adverse event whose pathogenesis remains incompletely understood. Initial hypotheses focused primarily on the spike protein antigen, with growing preclinical evidence im...
Crosstalk Between Inflammation and Cellular Senescence in Osteoarthritis: Modulatory Actions of Olive Oil and Its Bioactive Compounds [0.03%]
橄榄油及其活性化合物对骨关节炎中炎症与细胞衰老的交互作用的调节功能
Alessandro Medoro,Roberta Tardugno,Sergio Davinelli et al.
Alessandro Medoro et al.
Osteoarthritis is a degenerative joint disorder characterized by progressive cartilage degradation, subchondral bone alterations, and persistent low-grade inflammation. Recent findings have identified a strong interplay between inflammation...
Neutrophil Extracellular Traps in Wound Healing of Diabetes: Mechanisms, Inducers, and Therapeutic Implications [0.03%]
糖尿病伤口愈合中中性粒细胞胞外诱捕网的研究：机制、诱导因素及治疗意义
Jiaojiao Xue,Zeyu Wang,Wenxiu Qi
Jiaojiao Xue
Wound healing damage, especially diabetic foot ulcer (DFU), is a serious complication of diabetes mellitus (DM). New evidence shows that neutrophil extracellular traps (NETs) are the key factor of this pathology. This review summarizes the ...
Association Between C-Reactive Protein-Triglyceride Glucose Index and Adverse Cardiovascular Outcomes in Acute Coronary Syndrome Patients With Prior Coronary Artery Bypass Grafting [0.03%]
C-反应蛋白-甘油三酯-血糖指数与既往冠脉搭桥急性冠状动脉综合征患者不良心血管结局的关系
Xiaoteng Ma,Huijun Chu,Qiuxuan Li et al.
Xiaoteng Ma et al.
Background: Patients with acute coronary syndrome (ACS) who have previously undergone coronary artery bypass grafting (CABG) represent a complex, high-risk population characterized by a substantial burden of atheroscleros...
Hydroxysafflor Yellow A Induces Apoptosis and Inhibits Inflammatory Cytokine Expression in Rheumatoid Arthritis Synovial Fibroblasts Through the MEK-ERK Pathway [0.03%]
通过MEK-ERK途径诱导滑膜成纤维细胞凋亡和抑制炎症细胞因子的羟基红花黄色素A
Dongwei Li,Hongkai Yang,Yao Feng et al.
Dongwei Li et al.
Objective: The objective of this study was to investigate whether hydroxysafflor yellow A (HSYA) affects the proliferation and apoptosis of fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis (RA). Synovial fibrob...
Qingxin Lianzi Yin Improves Chronic Kidney Disease by Targeting Ferroptosis via the TLR4/HIF-1α Pathway [0.03%]
清心莲子饮通过TLR4/HIF-1α通路靶向铁死亡改善慢性肾脏病
Binqi Wang,Bo Lin,Danna Zheng et al.
Binqi Wang et al.
Background: Ferroptosis is involved in the pathogenesis of chronic kidney disease (CKD). Qingxin Lianzi Yin (QXLZY) has shown significant advantages in CKD treatment. This investigation intended to explore the impact of Q...